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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciMLAB410358:G1G83-1336-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Mlab_1253
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001329691 – 247DNA polymerase sliding clampAdd BLAST247

Proteomic databases

PRIDEiA2SSW6

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi410358.Mlab_1253

Structurei

3D structure databases

ProteinModelPortaliA2SSW6
SMRiA2SSW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN

Sequencei

Sequence statusi: Complete.

A2SSW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKATIEADI FRETIDAVSA LVNECRLHVD EKGIRTITVD TSNVAMVSLE
60 70 80 90 100
LSASAFLTFA AEPCEIGLDI EKIRSMMSMI GKTDIVSLEL DESGKKLKIS
110 120 130 140 150
FGGYEYSITL LDTKTIRKDP NAPNLNLPAT FEVPGVMFND AIKASSMVSD
160 170 180 190 200
KISLAVSAET CVFTMNADGD SDRIKRELTG DDVHYLTCAD ARSLFSLDYL
210 220 230 240
KDMGKSIGRA EKVQIRLGTD HPVQFSFVYA GGKGSVGYLL APRIEAD
Length:247
Mass (Da):26,908
Last modified:March 6, 2007 - v1
Checksum:i8D91CF331E249907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA Translation: ABN07422.1
RefSeqiWP_011833625.1, NC_008942.1

Genome annotation databases

EnsemblBacteriaiABN07422; ABN07422; Mlab_1253
GeneIDi4794814
KEGGimla:Mlab_1253

Similar proteinsi

Entry informationi

Entry nameiPCNA_METLZ
AccessioniPrimary (citable) accession number: A2SSW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health