A2SSW4 (PGK_METLZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	Mlab_1251

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm Potential HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Phosphoglycerate kinase HAMAP MF_00145		PRO_1000058016
Regions
	Nucleotide binding	355 – 358	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	59 – 62	4	Substrate binding By similarity
Sites
	Binding site	38	1	Substrate By similarity
	Binding site	116	1	Substrate By similarity
	Binding site	156	1	Substrate By similarity
	Binding site	330	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2SSW4 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: F0D097A7F5ADB00D	FASTA	405	43,953
	10 20 30 40 50 60 MNFGTLADIE TRGKTVLVRV DFNSPIDPSS NTILDDKRFR EHIPTLQALE DARVVVLAHQ 70 80 90 100 110 120 SRPGKKDFTT LAAHADKLER LMNMPVTYVD DIFGTCAKHA VRDAHPGDIV LLENVRFSAE 130 140 150 160 170 180 ENLTMKPEDG AKTHLVRKLA SMADLFVYDA FGTAHRSQPT ITGLSYAMKT VAGLLMEKEV 190 200 210 220 230 240 SMLSRVFTSA PKPVTFVLGG TKVDDSIAVA GNVLANKTAD KVAIIGVVAN VFYLAKGIDI 250 260 270 280 290 300 GEPSRNLIHM LGYDDEVAKA KTILDSYPDK VLLPEYVAVK EHDERKEYPI TRVPKDCPIL 310 320 330 340 350 360 DMGTESIVQF SKALRNSGSI VFNGPAGVFE EAKFASGTFE LLRAAANVDF SVCGGGHTAA 370 380 390 400 VIEQLGLEPQ YSHLSTGGGA CIEFLTGKKL PAIAALEESW KKFGN

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) [PubMed: 21304657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN07420.1.
RefSeq	YP_001030687.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SSW4.
ModBase	Search...
Protein-protein interaction databases
STRING	A2SSW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4794834.
GenomeReviews	Gene locus Mlab_1251 in contig CP000559_GR.
KEGG	mla:Mlab_1251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04384.
HOGENOM	HBG453500.
OMA	PGKKDFT.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	MLAB410358:MLAB_1251-MONOMER.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KO	K00927.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_METLZ

Accession

Primary (citable) accession number: A2SSW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 6, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program