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A2SS72 (FTHS_METLZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Mlab_1009
OrganismMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]
Taxonomic identifier410358 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293075

Regions

Nucleotide binding70 – 778ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2SS72 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: C8466B9193943ECA

FASTA56059,858
        10         20         30         40         50         60 
MGWKYLLSDI EIAQQCKMKK ITEIAASLDI TPDELELYGS YKAKLADSLE KRLADKPNGK 

        70         80         90        100        110        120 
LILVTAINPT PAGEGKTTTT VGLGQAMPKI GKKAVIALRE PSLGPVFGVK GGAAGGGYSQ 

       130        140        150        160        170        180 
VVPMEDINLH FTGDFHAITS ANNLLCAMID NHIQQGNALD IDTRRIIFKR CLDMNDRALR 

       190        200        210        220        230        240 
NIIIGLGGQT NGVPREDHFM ITVASEVMAI LCLANDIDDL KERLGNVIFG YSRKGTPLYA 

       250        260        270        280        290        300 
RDLKAVGAMA ALLKDAIKPN LVQTLENTPC FIHGGPFANI AHGCNSVRAT KLSLKMADYV 

       310        320        330        340        350        360 
ITEAGFGSDL GAEKFFDIKC RYAGLTPNTV VLVATVRALK YNGGVKKEDT TIPNVAALKA 

       370        380        390        400        410        420 
GMVNLEAHIQ NLQTFGVPVV VAINRFSTDT DEELAVLKEF CTAQGAEFAI SEVFAKGGEG 

       430        440        450        460        470        480 
GVELAKKVVA SCEKPQKFQC LYELNTPIKE KINALATRIY GADGVVYSPA ADAAIKDIDA 

       490        500        510        520        530        540 
LGRSNLPICM AKTQYSLSDD PNKLGRPKNF VINAATVRLC NGAGFIVVET GDIMTLPGLP 

       550        560 
AVPAACSIDV NNDGYISGLF 

« Hide

References

[1]"Complete genome sequence of Methanocorpusculum labreanum type strain Z."
Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:197-203(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000559 Genomic DNA. Translation: ABN07178.1.
RefSeqYP_001030445.1. NC_008942.1.

3D structure databases

ProteinModelPortalA2SS72.
SMRA2SS72. Positions 9-558.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410358.Mlab_1009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN07178; ABN07178; Mlab_1009.
GeneID4794627.
KEGGmla:Mlab_1009.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.

Enzyme and pathway databases

BioCycMLAB410358:GH7C-1038-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_METLZ
AccessionPrimary (citable) accession number: A2SS72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways