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A2SS72

- FTHS_METLZ

UniProt

A2SS72 - FTHS_METLZ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 778ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLAB410358:GH7C-1038-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Mlab_1009
    OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
    Taxonomic identifieri410358 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
    ProteomesiUP000000365: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_0000293075Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410358.Mlab_1009.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SS72.
    SMRiA2SS72. Positions 9-558.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2SS72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWKYLLSDI EIAQQCKMKK ITEIAASLDI TPDELELYGS YKAKLADSLE    50
    KRLADKPNGK LILVTAINPT PAGEGKTTTT VGLGQAMPKI GKKAVIALRE 100
    PSLGPVFGVK GGAAGGGYSQ VVPMEDINLH FTGDFHAITS ANNLLCAMID 150
    NHIQQGNALD IDTRRIIFKR CLDMNDRALR NIIIGLGGQT NGVPREDHFM 200
    ITVASEVMAI LCLANDIDDL KERLGNVIFG YSRKGTPLYA RDLKAVGAMA 250
    ALLKDAIKPN LVQTLENTPC FIHGGPFANI AHGCNSVRAT KLSLKMADYV 300
    ITEAGFGSDL GAEKFFDIKC RYAGLTPNTV VLVATVRALK YNGGVKKEDT 350
    TIPNVAALKA GMVNLEAHIQ NLQTFGVPVV VAINRFSTDT DEELAVLKEF 400
    CTAQGAEFAI SEVFAKGGEG GVELAKKVVA SCEKPQKFQC LYELNTPIKE 450
    KINALATRIY GADGVVYSPA ADAAIKDIDA LGRSNLPICM AKTQYSLSDD 500
    PNKLGRPKNF VINAATVRLC NGAGFIVVET GDIMTLPGLP AVPAACSIDV 550
    NNDGYISGLF 560
    Length:560
    Mass (Da):59,858
    Last modified:March 6, 2007 - v1
    Checksum:iC8466B9193943ECA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN07178.1.
    RefSeqiWP_011833381.1. NC_008942.1.
    YP_001030445.1. NC_008942.1.

    Genome annotation databases

    EnsemblBacteriaiABN07178; ABN07178; Mlab_1009.
    GeneIDi4794627.
    KEGGimla:Mlab_1009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN07178.1 .
    RefSeqi WP_011833381.1. NC_008942.1.
    YP_001030445.1. NC_008942.1.

    3D structure databases

    ProteinModelPortali A2SS72.
    SMRi A2SS72. Positions 9-558.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410358.Mlab_1009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN07178 ; ABN07178 ; Mlab_1009 .
    GeneIDi 4794627.
    KEGGi mla:Mlab_1009.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MLAB410358:GH7C-1038-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43576 / DSM 4855 / Z.

    Entry informationi

    Entry nameiFTHS_METLZ
    AccessioniPrimary (citable) accession number: A2SS72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3