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A2SS72

- FTHS_METLZ

UniProt

A2SS72 - FTHS_METLZ

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-1038-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Mlab_1009
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
ProteomesiUP000000365: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_0000293075Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi410358.Mlab_1009.

Structurei

3D structure databases

ProteinModelPortaliA2SS72.
SMRiA2SS72. Positions 9-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SS72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWKYLLSDI EIAQQCKMKK ITEIAASLDI TPDELELYGS YKAKLADSLE
60 70 80 90 100
KRLADKPNGK LILVTAINPT PAGEGKTTTT VGLGQAMPKI GKKAVIALRE
110 120 130 140 150
PSLGPVFGVK GGAAGGGYSQ VVPMEDINLH FTGDFHAITS ANNLLCAMID
160 170 180 190 200
NHIQQGNALD IDTRRIIFKR CLDMNDRALR NIIIGLGGQT NGVPREDHFM
210 220 230 240 250
ITVASEVMAI LCLANDIDDL KERLGNVIFG YSRKGTPLYA RDLKAVGAMA
260 270 280 290 300
ALLKDAIKPN LVQTLENTPC FIHGGPFANI AHGCNSVRAT KLSLKMADYV
310 320 330 340 350
ITEAGFGSDL GAEKFFDIKC RYAGLTPNTV VLVATVRALK YNGGVKKEDT
360 370 380 390 400
TIPNVAALKA GMVNLEAHIQ NLQTFGVPVV VAINRFSTDT DEELAVLKEF
410 420 430 440 450
CTAQGAEFAI SEVFAKGGEG GVELAKKVVA SCEKPQKFQC LYELNTPIKE
460 470 480 490 500
KINALATRIY GADGVVYSPA ADAAIKDIDA LGRSNLPICM AKTQYSLSDD
510 520 530 540 550
PNKLGRPKNF VINAATVRLC NGAGFIVVET GDIMTLPGLP AVPAACSIDV
560
NNDGYISGLF
Length:560
Mass (Da):59,858
Last modified:March 6, 2007 - v1
Checksum:iC8466B9193943ECA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07178.1.
RefSeqiWP_011833381.1. NC_008942.1.
YP_001030445.1. NC_008942.1.

Genome annotation databases

EnsemblBacteriaiABN07178; ABN07178; Mlab_1009.
GeneIDi4794627.
KEGGimla:Mlab_1009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07178.1 .
RefSeqi WP_011833381.1. NC_008942.1.
YP_001030445.1. NC_008942.1.

3D structure databases

ProteinModelPortali A2SS72.
SMRi A2SS72. Positions 9-558.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410358.Mlab_1009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN07178 ; ABN07178 ; Mlab_1009 .
GeneIDi 4794627.
KEGGi mla:Mlab_1009.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MLAB410358:GH7C-1038-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43576 / DSM 4855 / Z.

Entry informationi

Entry nameiFTHS_METLZ
AccessioniPrimary (citable) accession number: A2SS72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3