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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLAB410358:G1G83-786-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Mlab_0747
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003310081 – 560Glutamate--tRNA ligaseAdd BLAST560

Proteomic databases

PRIDEiA2SRG2

Interactioni

Protein-protein interaction databases

STRINGi410358.Mlab_0747

Structurei

3D structure databases

ProteinModelPortaliA2SRG2
SMRiA2SRG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi108 – 118"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A2SRG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADADIRNDI YVLALENAVK HKAVPRAGAI LGSVMGAHPE LRSKAKEINA
60 70 80 90 100
LIPEILEEVA ALSIEEREEK LMSLNPGAIE KMHEKKERSH ELPDLPNAES
110 120 130 140 150
GVVMRFAPNP SGPLHLGHAR ASVLNDYYVK KYGGKFYYRV EDTDPKRVDP
160 170 180 190 200
SAYEMVSEDL AWLGIGITDV VYQSDRFAIY YEYARKLLEL GGAYMCTCDN
210 220 230 240 250
NEFREKKLKK IACPCREISV EENLKRFDDM LAGKYAEGEI TLRVKTDIAH
260 270 280 290 300
PDPAVRDFAA MRVLTSTPHP RKPAIFVYPL MNFSVAVDDH LLGMTHVIRG
310 320 330 340 350
KDHIANTRRQ EYIYNYFGWK MPYFYHYGRM SIAGLELSTS GMRKGINEGL
360 370 380 390 400
YTGWDDIHLG TLRALARRGI QPEAVRAATI DIGMGDTDIS FSWENLFAQN
410 420 430 440 450
KAVIDAGADR YFFVPDAVEV EIAGAPKTEA HAPVYPNQPE RGERVLPFTG
460 470 480 490 500
RVLLPKSEME KGGMLRLKDL FNINITGPNS AEYAGDSLAE ARSQKAAIVQ
510 520 530 540 550
WLPTETAAPC SLLTPEGIQE GFSEPAVLGY LGRIVQFERV GFSKIDAVND
560
GKVIAYFTHR
Length:560
Mass (Da):62,583
Last modified:March 6, 2007 - v1
Checksum:iE0D76327B9491F70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA Translation: ABN06918.1
RefSeqiWP_011833119.1, NC_008942.1

Genome annotation databases

EnsemblBacteriaiABN06918; ABN06918; Mlab_0747
GeneIDi4795118
KEGGimla:Mlab_0747

Similar proteinsi

Entry informationi

Entry nameiSYE_METLZ
AccessioniPrimary (citable) accession number: A2SRG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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