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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601GTPUniRule annotation
Binding sitei163 – 1631GTPUniRule annotation
Binding sitei206 – 2061GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 465GTPUniRule annotation
Nucleotide bindingi129 – 1313GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-764-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Mlab_0743Imported
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)Imported
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi410358.Mlab_0743.

Structurei

3D structure databases

ProteinModelPortaliA2SRF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 224191TubulinInterPro annotationAdd
BLAST
Domaini226 – 343118Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiWGARIQD.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SRF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIINEALK NSELEKGMQT TSIVDDDDML GQPRIVIVGC GGAGNNTINR
60 70 80 90 100
LHNMKVAGSE TIAINTDKQH LDMIQADKRV LIGKSLTRGL GAGGFPDVGR
110 120 130 140 150
RAAEMARPTL EEILKDADLV FVTAGMGGGT GTGSAPVVAQ IAKEHGAIVI
160 170 180 190 200
AMVSYPFQVE RARMLKAEDG LEAMRQAADS VIVLDNNRLK NFVPNLPLGQ
210 220 230 240 250
AFSVMDQLIA ETVKGISETI TEPSLINIDY ADVRAIMSKG GLAVMLVGES
260 270 280 290 300
KQQNKAESVI RDCLAHPLLD IDFRGATGSL IHITGGNDLT LHDAEEIAQQ
310 320 330 340 350
LTYELDPHAD VIWGARVRKD FEGKVSVMAI MTGIQCPQVL GGHSVSTFQV
360 370 380
GNTSSNKSSQ SPSASSTHQQ NTATARSGSS FDWIM
Length:385
Mass (Da):41,065
Last modified:March 6, 2007 - v1
Checksum:i2B6C7AB3B114BBD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN06914.1.
RefSeqiWP_011833115.1. NC_008942.1.

Genome annotation databases

EnsemblBacteriaiABN06914; ABN06914; Mlab_0743.
GeneIDi4795107.
KEGGimla:Mlab_0743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN06914.1.
RefSeqiWP_011833115.1. NC_008942.1.

3D structure databases

ProteinModelPortaliA2SRF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410358.Mlab_0743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN06914; ABN06914; Mlab_0743.
GeneIDi4795107.
KEGGimla:Mlab_0743.

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiWGARIQD.

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-764-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43576 / DSM 4855 / ZImported.

Entry informationi

Entry nameiA2SRF8_METLZ
AccessioniPrimary (citable) accession number: A2SRF8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.