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Protein
Submitted name:

Uroporphyrin-III C-methyltransferase

Gene

Mlab_0526

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: InterPro
  2. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. oxidation-reduction process Source: InterPro
  2. peptidyl-pyrromethane cofactor linkage Source: InterPro
  3. porphyrin-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-543-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uroporphyrin-III C-methyltransferaseImported
Gene namesi
Ordered Locus Names:Mlab_0526Imported
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)Imported
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
ProteomesiUP000000365: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi410358.Mlab_0526.

Structurei

3D structure databases

ProteinModelPortaliA2SQU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0181.
KOiK02303.
OMAiCAIERIV.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF53790. SSF53790. 1 hit.
SSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
TIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SQU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIRIGTRG SKLALAQTKK VIGLLAENGI DAEYVIIKTT GDKVTDRGLH
60 70 80 90 100
QIGGFGMFVR ELDNAILRGE IDCAVHSMKD IPAERPKGLL TVAVLKRDPP
110 120 130 140 150
YDFLVMNGKV EDLMVIGTSS LRRKAQLLRY FHNCPAVRVE MLRGNLDTRL
160 170 180 190 200
GKLDDGLYDG IMVAEAGLMR LDYKRNGVRL SPDMFVPAAN QGTIAIVSRD
210 220 230 240 250
TPELRAAFAP LNDPQSALDC AIERIVMEQV GGGCFTPMGI FCENQHLTAE
260 270 280 290 300
VLSLDGTRAE RITAEIGDLE GARVAGIRLK NVGAELIAEA KLALGEPAKK
310 320 330 340 350
NGKVYLVGSG PGGLGLLTFR AREVIDLADV IMYDQLPGDE IIASLPARAE
360 370 380 390 400
KIDVGKYGGH HTMKQEDIEK LLVEKAQAGG IIVRLKGGDP FLFGRGGEEM
410 420 430 440 450
EVLREHNIPC EAIPGVTSGI AVPECVGIPV THRDFASQVT FVTGHENPEK
460 470 480 490 500
EVSSIDWKWL AGSPGTIVIY MGVKNLGRIA ELLIENGRDP QTKIAVIERG
510 520 530 540
FRPDQRVTCA TLADIGEVSK KVGMKPPAII VIGEVVGLYK EE
Length:542
Mass (Da):58,669
Last modified:March 6, 2007 - v1
Checksum:i2886135507DF4E13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN06700.1.
RefSeqiYP_001029967.1. NC_008942.1.

Genome annotation databases

EnsemblBacteriaiABN06700; ABN06700; Mlab_0526.
GeneIDi4795961.
KEGGimla:Mlab_0526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN06700.1.
RefSeqiYP_001029967.1. NC_008942.1.

3D structure databases

ProteinModelPortaliA2SQU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410358.Mlab_0526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN06700; ABN06700; Mlab_0526.
GeneIDi4795961.
KEGGimla:Mlab_0526.

Phylogenomic databases

eggNOGiCOG0181.
KOiK02303.
OMAiCAIERIV.

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-543-MONOMER.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF53790. SSF53790. 1 hit.
SSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
TIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43576 / DSM 4855 / ZImported.

Entry informationi

Entry nameiA2SQU4_METLZ
AccessioniPrimary (citable) accession number: A2SQU4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: February 4, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.