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A2SQU2 (A2SQU2_METLZ) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515
Gene names
Ordered Locus Names:Mlab_0524
OrganismMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]
Taxonomic identifier410358 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515

Sequence similarities

Belongs to the ALADH family. RuleBase RU004161

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1871Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Active site2401Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Metal binding1121Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding1141Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding1221Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding2251Magnesium By similarity PIRSR PIRSR001415-5
Binding site1971Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2091Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2661Substrate 2 By similarity PIRSR PIRSR001415-2
Binding site3051Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

Sequence LengthMass (Da)Tools
A2SQU2 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 905F41037FD8B531

FASTA31534,480
        10         20         30         40         50         60 
MRRLRQNILQ PMFKETRLVK DELIMPLFFD ENAVKPVPIA SMPGQFRHPL SCAEEVAEEM 

        70         80         90        100        110        120 
KAAGLRAVLL FGIPKCKDTE ASGAFAENGI VQEATRRIKA AVPDLIVITD TCACEYTSHG 

       130        140        150        160        170        180 
HCGILCGKEL DNDASLLLME KIAVSQAAAG ADMVAPSCML DGQVTAIREA LDEAGFSNTP 

       190        200        210        220        230        240 
IMSYSTKFAS ALYGPFREAA DSGFSFGDRT SYQMSPANRR EAIRESYLDE MEGADILMVK 

       250        260        270        280        290        300 
PAGFYLDILR DVRESTDLPV AAYQVSGEYS MIKAAGMNGW IDEKKIMMES LLAIKRAGAD 

       310 
LIITYFAKEA AEMLP

« Hide

References

[1]"Complete genome sequence of Methanocorpusculum labreanum type strain Z."
Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:197-203(2009)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000559 Genomic DNA. Translation: ABN06698.1.
RefSeqYP_001029965.1. NC_008942.1.

3D structure databases

ProteinModelPortalA2SQU2.
SMRA2SQU2. Positions 1-314.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2SQU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4795417.
GenomeReviewsGene locus Mlab_0524 in contig CP000559_GR.
KEGGmla:Mlab_0524.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05029.
HOGENOMHBG285270.
OMAADLCFCE.
PhylomeDBA2SQU2.
ProtClustDBPRK09283.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01698.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2SQU2_METLZ
AccessionPrimary (citable) accession number: A2SQU2
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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