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A2SQQ9 (A2SQQ9_METLZ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP MF_00079
Short name=ATP-PRT HAMAP MF_00079
Short name=ATP-PRTase HAMAP MF_00079
EC=2.4.2.17 HAMAP MF_00079
Gene names
Name:hisG HAMAP MF_00079
Ordered Locus Names:Mlab_0491
OrganismMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]
Taxonomic identifier410358 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP MF_00079

Sequences

Sequence LengthMass (Da)Tools
A2SQQ9 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: C89BA837CB8B0786

FASTA28630,947
        10         20         30         40         50         60 
MAKIRLAIPN KGRIAEPIND LMDKAGIHIN MTGSRQLIAK TIDPEIEVLF VRPIDIPEYV 

        70         80         90        100        110        120 
AKGVADLGIT GLDMVAERRA DVARLLDLKF GSAKLVIAVP QESPITSVET MNGCRIATEF 

       130        140        150        160        170        180 
PSICKDFFAE RSVEVNIIEV SGACEAAPHL GIADGIADLT SSGTTLEVNK LRIVEEILAS 

       190        200        210        220        230        240 
TTNVIANKTS LVEKHEKIEE ILLAFESVIA AKGQCYLMLN VKREKLEEIK ALIPGLGGPT 

       250        260        270        280 
IMDIAGSGSV ALHAVVSTNK VYQLINQLKR AGARDILVLD IMRMVR

« Hide

References

[1]"Complete genome sequence of Methanocorpusculum labreanum type strain Z."
Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:197-203(2009)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000559 Genomic DNA. Translation: ABN06665.1.
RefSeqYP_001029932.1. NC_008942.1.

3D structure databases

ProteinModelPortalA2SQQ9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2SQQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4794546.
GenomeReviewsGene locus Mlab_0491 in contig CP000559_GR.
KEGGmla:Mlab_0491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04876.
HOGENOMHBG391868.
OMAIMLHAPS.
PhylomeDBA2SQQ9.
ProtClustDBPRK00489.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2SQQ9_METLZ
AccessionPrimary (citable) accession number: A2SQQ9
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info