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A2SQM6

- TFE_METLZ

UniProt

A2SQM6 - TFE_METLZ

Protein

Transcription factor E

Gene

tfe

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.UniRule annotation

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMLAB410358:GH7C-474-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor EUniRule annotation
    Short name:
    TFEUniRule annotation
    Alternative name(s):
    TFIIE subunit alpha homologUniRule annotation
    Transcription initiation factor TFIIEUniRule annotation
    Gene namesi
    Name:tfeUniRule annotation
    Ordered Locus Names:Mlab_0458
    OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
    Taxonomic identifieri410358 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
    ProteomesiUP000000365: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Transcription factor EPRO_0000326603Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.UniRule annotation

    Protein-protein interaction databases

    STRINGi410358.Mlab_0458.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SQM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 130121HTH TFE/IIEalpha-typeUniRule annotationAdd
    BLAST

    Domaini

    The winged helix domain is involved in binding to DNA in the preinitiation complex.UniRule annotation

    Sequence similaritiesi

    Belongs to the TFE family.UniRule annotation
    Contains 1 HTH TFE/IIEalpha-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1675.
    HOGENOMiHOG000015477.
    KOiK03136.
    OMAiFENDFLC.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    HAMAPiMF_01909. TFE_arch.
    InterProiIPR016481. TF_E_archaea.
    IPR017919. TFIIE/TFIIEa_HTH.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR011991. WHTH_DNA-bd_dom.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view]
    PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2SQM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVITEEQLG NPAIYQYLLK LVGEEGLELL RRWSDVSYAR RWVEEKLSSE    50
    DLKAADKARF LAESRRSDED LVEAERSDEE IAELTGINLN SVRHTLYNLY 100
    EHRLAEYRRI KNNETGWLTY LWLMRMDHMN MVLRNEMEVA AGKLAGRLRY 150
    DEANDFYQCK NCGITTTFNN AMTTNFSCPQ CGTMLVHFDD ELIITALKKR 200
    LAKMQTALDN A 211
    Length:211
    Mass (Da):24,545
    Last modified:March 6, 2007 - v1
    Checksum:i52812E41EF45E768
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN06632.1.
    RefSeqiWP_011832833.1. NC_008942.1.
    YP_001029899.1. NC_008942.1.

    Genome annotation databases

    EnsemblBacteriaiABN06632; ABN06632; Mlab_0458.
    GeneIDi4794695.
    KEGGimla:Mlab_0458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN06632.1 .
    RefSeqi WP_011832833.1. NC_008942.1.
    YP_001029899.1. NC_008942.1.

    3D structure databases

    ProteinModelPortali A2SQM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410358.Mlab_0458.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN06632 ; ABN06632 ; Mlab_0458 .
    GeneIDi 4794695.
    KEGGi mla:Mlab_0458.

    Phylogenomic databases

    eggNOGi COG1675.
    HOGENOMi HOG000015477.
    KOi K03136.
    OMAi FENDFLC.

    Enzyme and pathway databases

    BioCyci MLAB410358:GH7C-474-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    HAMAPi MF_01909. TFE_arch.
    InterProi IPR016481. TF_E_archaea.
    IPR017919. TFIIE/TFIIEa_HTH.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR011991. WHTH_DNA-bd_dom.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view ]
    PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43576 / DSM 4855 / Z.

    Entry informationi

    Entry nameiTFE_METLZ
    AccessioniPrimary (citable) accession number: A2SQM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3