A2SQJ8 (PPNK_METLZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	Mlab_0428

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000059879

Sequences

	Sequence		Length	Mass (Da)
	A2SQJ8 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 9FFA2446BF73A4D6	FASTA	271	29,533
	10 20 30 40 50 60 MKICIVSRID LKEPVELAQS LGWMLRDQGH DVVYEQSVAA ELGYAPVSLS KDFSADLIVV 70 80 90 100 110 120 LGGDGSVLRT IRMLDHQVPV VGINQGQVGF LTDIERDKAE EILTSLSLPL PLDPRMRISI 130 140 150 160 170 180 EFNGRSVGSA LNEAVIVTSR PAKILKFAVF VNGRQIDEFR ADGLIIGTPT GSTAYAMSAG 190 200 210 220 230 240 GPIVDSTIEA MLLVPLAPYM LSSRPYLINS NSEVEIRLVS VKPALLVIDG QDQYEIGENA 250 260 270 TLLIRKSPDP ALFVDVGRGF FDKVEQKLRL L

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) [PubMed: 21304657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN06604.1.
RefSeq	YP_001029871.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SQJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	A2SQJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4794383.
GenomeReviews	Gene locus Mlab_0428 in contig CP000559_GR.
KEGG	mla:Mlab_0428.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04399.
HOGENOM	HBG713904.
OMA	PALNEIV.
PhylomeDB	A2SQJ8.
ProtClustDB	CLSK949537.
Enzyme and pathway databases
BioCyc	MLAB410358:MLAB_0428-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_METLZ

Accession

Primary (citable) accession number: A2SQJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 6, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program