A2SQI3 (A2SQI3_METLZ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Mlab_0413

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length	824 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding HAMAP MF_01897 DNA-binding HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2SQI3 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 64B9B57A376A44FD	FASTA	824	91,140
	10 20 30 40 50 60 MTSEENTTHK TVSINIEDEM KNCFIDYAMS VIIGRAIPDV RDGLKPVHRR ILYAMFHDEG 70 80 90 100 110 120 NTSDKAYKKS AKAVAATMGN YHPHGDSAIY DTLVKMAQPF SYRYTLVDGQ GNFGSIDGDS 130 140 150 160 170 180 AAAMRYTEAR LTKAAESLLE DIDKETVDFV PNFDESSQEP DVLPSRIPNL LVNGTTGIAV 190 200 210 220 230 240 GMATNMMPHN LGEVCDLVDA YIDNPEMSLE EMMKILPAPD FPTGGKIMGT DGIVNAYQTG 250 260 270 280 290 300 QGKVVLRGIA EIEERKKGFE QIVITEIPYQ VNKAAMIEKI ADLVKSKTIE GISDIRDESD 310 320 330 340 350 360 KDGIRVIIEL KQNTQANVVL NLLYKHTQLE SSFGIINLAI VDKKPKILSL AELLRHFIAH 370 380 390 400 410 420 RVDVVRRRSL FDLRKAEERM HILSGLLKAL DMIDVVIATI RASPEVSVAQ EALVSKLGFS 430 440 450 460 470 480 EAQAEAILKM QLRRLAALEQ QKILDETTSL QLVIDKLTWI LSSEENILSV VKTETSEIRT 490 500 510 520 530 540 AYADERRTQI DYTANTDFNV MDLIPDEQTL VMLTTQNYIK RVPLDLYRQQ KRGGRGVIGM 550 560 570 580 590 600 TTKDEDSVDK VFLANTHDYL LCFTNKGRVY WLRVYEIPEG SRTSKGKAIV NLLNLTDEEV 610 620 630 640 650 660 SAVIPMRDFD AEKNLLYATK KGRVGKFSQD LFSRPRTGGI IGITLLDGDE LVDVVVTDGS 670 680 690 700 710 720 TDVVLTTAFG QALRFSEDEV RATGRGTQGV IGIRLKFEGD YVCALTLVET QYLLMITDKG 730 740 750 760 770 780 FGKRTEFEEF RGHGRGTQGV KSIVANFERG KVVSSLAVSD DDQVIITTAG GVVLRTSASD 790 800 810 820 ISIQGRGTKG VRVIRVDSGD KVTSVAIVPP DEDEPALPEA TDEA

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN06589.1.
RefSeq	YP_001029856.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SQI3.
SMR	A2SQI3. Positions 33-491.
ModBase	Search...
Protein-protein interaction databases
STRING	A2SQI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4794491.
GenomeReviews	Gene locus Mlab_0413 in contig CP000559_GR.
KEGG	mla:Mlab_0413.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05278.
HOGENOM	HBG635183.
OMA	TGRGRIY.
PhylomeDB	A2SQI3.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2SQI3_METLZ

Accession

Primary (citable) accession number: A2SQI3

Entry history

Integrated into UniProtKB/TrEMBL:	March 6, 2007
Last sequence update:	March 6, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)