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A2SQ87 (PYRE_METLZ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:Mlab_0317
OrganismMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]
Taxonomic identifier410358 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000298884

Regions

Region111 – 11995-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site8615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1151Orotate By similarity
Binding site1431Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
A2SQ87 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 96A4B600B408FA8B

FASTA16917,757
        10         20         30         40         50         60 
MVNRILDLLI QYKAVEFGDF TLASGAQSKY YIDVKTAIMQ PELLSEIAAE VAKKYDFECI 

        70         80         90        100        110        120 
AGVAVGGVPL AVAVSLAANK PCAVIRAAAK DHGKSQMIIG NVKGQRVLLI EDVTTSGGSS 

       130        140        150        160 
KYGVEELRKA GALIDSVVTV VDREGGAEEL LAAEGITLHP LVKASELLA

« Hide

References

[1]"Complete genome sequence of Methanocorpusculum labreanum type strain Z."
Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:197-203(2009) [PubMed: 21304657] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000559 Genomic DNA. Translation: ABN06493.1.
RefSeqYP_001029760.1. NC_008942.1.

3D structure databases

ProteinModelPortalA2SQ87.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2SQ87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4795219.
GenomeReviewsGene locus Mlab_0317 in contig CP000559_GR.
KEGGmla:Mlab_0317.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG09150.
HOGENOMHBG404341.
OMAQTCLVIN.
PhylomeDBA2SQ87.
ProtClustDBPRK13811.

Enzyme and pathway databases

BioCycMLAB410358:MLAB_0317-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_METLZ
AccessionPrimary (citable) accession number: A2SQ87
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 6, 2007
Last modified: November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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