Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A2SQ86

- PUR2_METLZ

UniProt

A2SQ86 - PUR2_METLZ

Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi272 – 2721Magnesium or manganese 1UniRule annotation
    Metal bindingi284 – 2841Magnesium or manganese 1UniRule annotation
    Metal bindingi284 – 2841Magnesium or manganese 2UniRule annotation
    Metal bindingi286 – 2861Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi136 – 19257ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLAB410358:GH7C-321-MONOMER.
    UniPathwayiUPA00074; UER00125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
    Alternative name(s):
    GARSUniRule annotation
    Glycinamide ribonucleotide synthetaseUniRule annotation
    Phosphoribosylglycinamide synthetaseUniRule annotation
    Gene namesi
    Name:purDUniRule annotation
    Ordered Locus Names:Mlab_0316
    OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
    Taxonomic identifieri410358 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
    ProteomesiUP000000365: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Phosphoribosylamine--glycine ligasePRO_1000018823Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410358.Mlab_0316.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SQ86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 314206ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GARS family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0151.
    HOGENOMiHOG000033464.
    KOiK01945.
    OMAiYKGFLYA.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPiMF_00138. GARS.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00877. purD. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2SQ86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILVAGGGG REHAICLALT KNANVELYSV MGKKNPGIAK IARESFIHAE    50
    TDVPAVLAFA KEHNIQYAVV GPEAPLEAGL VDALTKAGIG CVGPVKAAAR 100
    IETDKGFCRG LMNKYGIDGC PAYKLCNTPK EAAEFIREYP GDLAVKPTGL 150
    TGGKGVKVMG EQVDREGAVE YAMTLKDQVI ILEERLLGEE FTLMAFVDGK 200
    HLVPMPLVQD HKRAFEGDVG PNTGGMGSYS LENHKFPFVT EDDYAKAISI 250
    MQATIDALAQ EGSPYKGILY GQFMNTKTGP KVIEFNARFG DPEAMNVLSI 300
    LTSDFLTIAE HIINGTLSAN DVSFEEKATV CKYIVPMDYP DKPHAGDVIT 350
    VGPAENTILY YANIALENGV LMTLTSRTMA YVGIGASLAE AEKYAEAACR 400
    NVSGNVRYRS DIGTEALFAK RIAHMKELRS 430
    Length:430
    Mass (Da):46,326
    Last modified:March 6, 2007 - v1
    Checksum:i0191C23BB1CABECF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN06492.1.
    RefSeqiWP_011832693.1. NC_008942.1.
    YP_001029759.1. NC_008942.1.

    Genome annotation databases

    EnsemblBacteriaiABN06492; ABN06492; Mlab_0316.
    GeneIDi4795228.
    KEGGimla:Mlab_0316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000559 Genomic DNA. Translation: ABN06492.1 .
    RefSeqi WP_011832693.1. NC_008942.1.
    YP_001029759.1. NC_008942.1.

    3D structure databases

    ProteinModelPortali A2SQ86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410358.Mlab_0316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN06492 ; ABN06492 ; Mlab_0316 .
    GeneIDi 4795228.
    KEGGi mla:Mlab_0316.

    Phylogenomic databases

    eggNOGi COG0151.
    HOGENOMi HOG000033464.
    KOi K01945.
    OMAi YKGFLYA.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00125 .
    BioCyci MLAB410358:GH7C-321-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPi MF_00138. GARS.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00877. purD. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43576 / DSM 4855 / Z.

    Entry informationi

    Entry nameiPUR2_METLZ
    AccessioniPrimary (citable) accession number: A2SQ86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3