Skip Header

Contribute Send feedback
Read comments (?) or add your own

A2SPX2 (A2SPX2_METLZ) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:Mlab_0202
OrganismMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]
Taxonomic identifier410358 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site21For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2391Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3851Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4361Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4391Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A2SPX2 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 791DB05CC9956806

FASTA46751,038
        10         20         30         40         50         60 
MCGITGITDS TDVSGSLYLA LYALQHRGQE SAGICTYDGE TVHRYKGYGL VSEVFSGPIL 

        70         80         90        100        110        120 
DGLRGKTGIG HVRYPTTGGS KPENIQPFHF MFRDHSLSLV HNGNLINTDE LRYEYEGHGH 

       130        140        150        160        170        180 
IFSTTSDTEV IAAIIANEII HDHTPDEAIS YCMRKISGSY VVIFMLDGIL YSFRDPLGIK 

       190        200        210        220        230        240 
PLCLGKTETG GHVLASESVA LDAIGAEFIR DIRPGESVRL QGGEVFSRQV MKAKSCAHCM 

       250        260        270        280        290        300 
FEYVYFARAD AVIDGVSVYD VRRKTGALLA REAPAKADLI SPVPDSGTAA ATGFSRESGT 

       310        320        330        340        350        360 
PFREALIKNR YTGRTFIMPS QEKREIAVRM KLNPVRGHIK DKSVVLVDDS IVRGTTSKKI 

       370        380        390        400        410        420 
LSLVREFGAK ELHLRIASPP IIAPCYLGTD FPTRDELIAS TKSVSQVEKE IDATSLAHIS 

       430        440        450        460 
LDGLIKAIGI PRQDLCLGCL TGKYPLAIPG EKEDDREIEM VDSYSCP

« Hide

References

[1]"Complete genome sequence of Methanocorpusculum labreanum type strain Z."
Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:197-203(2009)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000559 Genomic DNA. Translation: ABN06378.1.
RefSeqYP_001029645.1. NC_008942.1.

3D structure databases

ProteinModelPortalA2SPX2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2SPX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4795722.
GenomeReviewsGene locus Mlab_0202 in contig CP000559_GR.
KEGGmla:Mlab_0202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04070.
HOGENOMHBG392416.
OMAVWAPGEE.
PhylomeDBA2SPX2.
ProtClustDBCLSK964665.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2SPX2_METLZ
AccessionPrimary (citable) accession number: A2SPX2
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info