A2SPJ8 (A2SPJ8_METLZ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
5,10-methylenetetrahydromethanopterin reductase HAMAP MF_01091
EC=1.5.99.11 HAMAP MF_01091

Alternative name(s):
Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase HAMAP MF_01091
Methylene-H(4)MPT reductase HAMAP MF_01091

Gene names

Name:	mer HAMAP MF_01091
Ordered Locus Names:	Mlab_0076

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible reduction of methylene-H4MPT to methyl-H4MPT By similarity. HAMAP MF_01091
Catalytic activity	5-methyltetrahydromethanopterin + coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. HAMAP MF_01091
Pathway	One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2. HAMAP MF_01091
Subcellular location	Cytoplasm By similarity HAMAP MF_01091.
Sequence similarities	Belongs to the mer family. HAMAP MF_01091

Ontologies

Keywords
Biological process	Methanogenesis HAMAP MF_01091 One-carbon metabolism HAMAP MF_01091
Cellular component	Cytoplasm HAMAP MF_01091
Molecular function	Oxidoreductase HAMAP MF_01091 EMBL ABN06254.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: HAMAP one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2SPJ8 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: D3DA9E6C7706B647	FASTA	327	34,347
	10 20 30 40 50 60 MTYGIEFVPG NVNVKQVVNF CQLAESKDID FAWITNHYNN RHCYPVLTAV AQATTTLKMG 70 80 90 100 110 120 PGIMNAFTDT PAAMASFACT LNEISDGRAT LGIGPGDLST LPKLAIQPTK PVARLGEAID 130 140 150 160 170 180 QIRALCSGAE VKKDGKEFFD YDGAKLTGVT LPGKKGIPIY VGAQGPKVLE LAGLKGDGAL 190 200 210 220 230 240 INASNPKDFA VAIPIIKAAC DSIGKKGFDV GAYTALSIDK DEKKAKKAAK IVAAFIAAGS 250 260 270 280 290 300 PEALLLRHGL DLANVAKIKD ALSRFDFGAV GGLVTDKEIE AFTICGTPDT IRQKCDDLTA 310 320 AGVTQIIFGS PLGPDMTTSI RLLGKIM

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN06254.1.
RefSeq	YP_001029521.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SPJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	A2SPJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4795466.
GenomeReviews	Gene locus Mlab_0076 in contig CP000559_GR.
KEGG	mla:Mlab_0076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04928.
HOGENOM	HBG497169.
OMA	GIEFVPG.
ProtClustDB	PRK02271.
Family and domain databases
HAMAP	MF_01091. F420_mer. [Tree]
InterPro	IPR011251. Luciferase-like_dom. IPR019946. MeH4methanopterin_reductase. [Graphical view]
Gene3D	G3DSA:3.20.20.30. Luciferase_like. 1 hit.
KO	K00320.
Pfam	PF00296. Bac_luciferase. 1 hit. [Graphical view]
SUPFAM	SSF51679. Luciferase_like. 1 hit.
TIGRFAMs	TIGR03555. F420_mer. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2SPJ8_METLZ

Accession

Primary (citable) accession number: A2SPJ8

Entry history

Integrated into UniProtKB/TrEMBL:	March 6, 2007
Last sequence update:	March 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)