A2SPI9 (TYPH_METLZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mlab_0067

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum › Methanocorpusculum labreanum

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314726

Sequences

	Sequence		Length	Mass (Da)
	A2SPI9 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: D3756779BAE97100	FASTA	505	53,294
	10 20 30 40 50 60 MNLILDMIDI STPVILLNDT DARQIGVLEG DRVTITRIKT KHTIAAPVSI TKTLTSQGTA 70 80 90 100 110 120 TISLGTNENL AAEKGDEIEI RAAPRPASIA FIRKKMDGGK FTREETATII SDMSSNVLSP 130 140 150 160 170 180 SEITAYITAA YINGLDMDEV EFLTREMVAS GEQITFSKKP VVDKHSIGGV PGNKITLLVV 190 200 210 220 230 240 PVIAASGLLI PKTSSRAITG AGGTADLMEA LAPVAFSAAE IKTMTEKAGG VIVWGGATNI 250 260 270 280 290 300 APADDMIVTY EYPLKIDARG QMLASIMAKK MAVGSDTCVI DIPIGPGTKI PDEAEGRVLA 310 320 330 340 350 360 NELITLGNRL GIRVECAVTF GGSPIGRNIG VNLEVSEALS LLEGKRGANS LVQKSVAIAG 370 380 390 400 410 420 IALEMTGKTG ADSGAEAAYD IIKKGKALKK MLDIIEIQGG DPKVKSTDFP VGEHTFVVPA 430 440 450 460 470 480 ASDGYVVSVK NQALISIARA AGSPVDHGAG LHLHKKPGEY VKRGEPLLTI YAERGWRLTR 490 500 AIEEARTSYP VLVEGMLLER ISSNR

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN06245.1.
RefSeq	YP_001029512.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SPI9.
ModBase	Search...
Protein-protein interaction databases
STRING	410358.Mlab_0067.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN06245; ABN06245; Mlab_0067.
GeneID	4795851.
KEGG	mla:Mlab_0067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MLAB410358:GH7C-67-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METLZ

Accession

Primary (citable) accession number: A2SPI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 6, 2007
Last modified:	May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program