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Protein

1-aminocyclopropane-1-carboxylate deaminase

Gene

acdS

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source.UniRule annotation

Catalytic activityi

1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMPET420662:GHBE-3643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate deaminaseUniRule annotation (EC:3.5.99.7UniRule annotation)
Short name:
ACC deaminaseUniRule annotation
Short name:
ACCDUniRule annotation
Gene namesi
Name:acdSUniRule annotation
Ordered Locus Names:Mpe_A3598
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
Proteomesi
  • UP000000366 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3383381-aminocyclopropane-1-carboxylate deaminasePRO_0000304378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi420662.Mpe_A3598.

Structurei

3D structure databases

ProteinModelPortaliA2SLW2.
SMRiA2SLW2. Positions 1-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022460.
KOiK01505.
OMAiKFGARTE.
OrthoDBiEOG6FBX0P.

Family and domain databases

HAMAPiMF_00807. ACC_deaminase.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005965. ACP_carboxylate_deaminase.
IPR020601. ACP_carboxylate_deaminase_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01274. ACC_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SLW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQRFPRHP LTFGPTPIQP LKRLSAHLGG QVELYAKRED CNSGLAFGGN
60 70 80 90 100
KTRKLEYLIP EALAQGCDTL VSIGGIQSNQ TRQVAAVAAH LGMKCVLVQE
110 120 130 140 150
NWVNYSDAVY DRVGNIEMSR ILGADVRLDA AGFDIGIRPS WEQAMADVRA
160 170 180 190 200
AGGKPFPIPA GCSEHRLGGL GFVGFAEEVR AQEAELGFKF DYIVVCSVTG
210 220 230 240 250
STQAGMVVGF AADGRAERVI GIDASAKPEQ THAQILRIAQ NTAELVGLGR
260 270 280 290 300
EITAQDVVLD TRYGGPEYGL PSEGTLEAIR LCARQEGMLT DPVYEGKSMH
310 320 330
GMIDKVKRGE FPAGSRVLYA HLGGVPALNA YSFLFRNG
Length:338
Mass (Da):36,363
Last modified:March 6, 2007 - v1
Checksum:iA829D1154DD24A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM96551.1.
RefSeqiWP_011831171.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM96551; ABM96551; Mpe_A3598.
KEGGimpt:Mpe_A3598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM96551.1.
RefSeqiWP_011831171.1. NC_008825.1.

3D structure databases

ProteinModelPortaliA2SLW2.
SMRiA2SLW2. Positions 1-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420662.Mpe_A3598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM96551; ABM96551; Mpe_A3598.
KEGGimpt:Mpe_A3598.

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022460.
KOiK01505.
OMAiKFGARTE.
OrthoDBiEOG6FBX0P.

Enzyme and pathway databases

BioCyciMPET420662:GHBE-3643-MONOMER.

Family and domain databases

HAMAPiMF_00807. ACC_deaminase.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005965. ACP_carboxylate_deaminase.
IPR020601. ACP_carboxylate_deaminase_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01274. ACC_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry namei1A1D_METPP
AccessioniPrimary (citable) accession number: A2SLW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 6, 2007
Last modified: December 9, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.