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A2SL36

- ACDH2_METPP

UniProt

A2SL36 - ACDH2_METPP

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Protein

Acetaldehyde dehydrogenase 2

Gene

Mpe_A3322

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediateUniRule annotation
Binding sitei274 – 2741NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi163 – 1719NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMPET420662:GHBE-3360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Mpe_A3322
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Acetaldehyde dehydrogenase 2PRO_0000387667Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A3322.

Structurei

3D structure databases

ProteinModelPortaliA2SL36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiAYVHRAN.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SL36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATKKIRCAL IGSGNIGTDL IYKLKRSAVL EPVWMVGIDA ASEGLQRARD
60 70 80 90 100
LGLKTTAEGV DGLLPHVKAD GIQIAFDATS AYVHPENSRK LNALGVLMVD
110 120 130 140 150
LTPAAVGPLC VPPVNLREHA AKLEMNVNMI SCAGQATIPI VYAVSRVQPV
160 170 180 190 200
DYAEIVASLA SKSIGPGTRA NLDEFTYTTS DALVRVGGAR RGKALAVINP
210 220 230 240 250
AEPPMIMRNT INCLTDDEPQ QARIIDSVLS MIEEVQQYVP GYKLVNGPVF
260 270 280 290 300
DGRRVSVFMQ VAGLGDYLPT YAGNLDIMTA AACRTAEMFA EEILAGTLQL

TPVKEAA
Length:307
Mass (Da):32,722
Last modified:March 6, 2007 - v1
Checksum:iD4071B19311366D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM96275.1.
RefSeqiWP_011830897.1. NC_008825.1.
YP_001022510.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM96275; ABM96275; Mpe_A3322.
GeneIDi4786421.
KEGGimpt:Mpe_A3322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM96275.1 .
RefSeqi WP_011830897.1. NC_008825.1.
YP_001022510.1. NC_008825.1.

3D structure databases

ProteinModelPortali A2SL36.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A3322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM96275 ; ABM96275 ; Mpe_A3322 .
GeneIDi 4786421.
KEGGi mpt:Mpe_A3322.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi AYVHRAN.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MPET420662:GHBE-3360-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiACDH2_METPP
AccessioniPrimary (citable) accession number: A2SL36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3