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Protein

Acetaldehyde dehydrogenase 2

Gene

Mpe_A3322

Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Acyl-thioester intermediateUniRule annotation1
Binding sitei274NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 16NADUniRule annotation4
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Mpe_A3322
OrganismiMethylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
Proteomesi
  • UP000000366 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876671 – 307Acetaldehyde dehydrogenase 2Add BLAST307

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A3322.

Structurei

3D structure databases

ProteinModelPortaliA2SL36.
SMRiA2SL36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK18366.
OMAiMIKVIRH.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SL36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKKIRCAL IGSGNIGTDL IYKLKRSAVL EPVWMVGIDA ASEGLQRARD
60 70 80 90 100
LGLKTTAEGV DGLLPHVKAD GIQIAFDATS AYVHPENSRK LNALGVLMVD
110 120 130 140 150
LTPAAVGPLC VPPVNLREHA AKLEMNVNMI SCAGQATIPI VYAVSRVQPV
160 170 180 190 200
DYAEIVASLA SKSIGPGTRA NLDEFTYTTS DALVRVGGAR RGKALAVINP
210 220 230 240 250
AEPPMIMRNT INCLTDDEPQ QARIIDSVLS MIEEVQQYVP GYKLVNGPVF
260 270 280 290 300
DGRRVSVFMQ VAGLGDYLPT YAGNLDIMTA AACRTAEMFA EEILAGTLQL

TPVKEAA
Length:307
Mass (Da):32,722
Last modified:March 6, 2007 - v1
Checksum:iD4071B19311366D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM96275.1.
RefSeqiWP_011830897.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM96275; ABM96275; Mpe_A3322.
KEGGimpt:Mpe_A3322.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH2_METPP
AccessioniPrimary (citable) accession number: A2SL36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 6, 2007
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families