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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Substrate1
Binding sitei142Substrate1
Binding sitei202Substrate1
Binding sitei232Substrate1
Binding sitei236Substrate1
Binding sitei237NAD1
Binding sitei289NAD1
Binding sitei324NAD1
Binding sitei390NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 205NAD3
Nucleotide bindingi266 – 271NAD6
Nucleotide bindingi345 – 347NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:Mpe_A3286
OrganismiMethylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
Proteomesi
  • UP000000366 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120561 – 477AdenosylhomocysteinaseAdd BLAST477

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A3286.

Structurei

3D structure databases

ProteinModelPortaliA2SL00.
SMRiA2SL00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SL00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKPTPT HDHHVADLSL ADWGRKEIKI AETEMPGLMA IRQEFAASQP
60 70 80 90 100
LKGARITGSL HMTIQTAVLV ETLQALGAQV RWASCNIFST QDHAAAALVA
110 120 130 140 150
AGTPVFAYKG ETLTDYWDYT HRIFDFGAKG TDGEGPNMIL DDGGDATLLM
160 170 180 190 200
HLGQKAEKDP SVISKPTSEE ETCLFAAIKA KLAQDPTWYT RKSAQIIGVT
210 220 230 240 250
EETTTGVHRL NEMSAKGTLL FRAINVNDSV TKSKFDNLYG CRESLVDSIK
260 270 280 290 300
RATDVMIAGK VACVAGYGDV GKGSAQALRA LSAQVWVTEI DPINALQAAM
310 320 330 340 350
EGYKVVTMEY AADKADIFVS ATGNKNVIRY EHMAAMKDEA IVCNIGHFDN
360 370 380 390 400
EIDVASLEKL KWDEIKPQVD HVVFPDGKKI TLLAKGRLVN LGCATGHPSF
410 420 430 440 450
VMSSSFANQT IAQIELFTKS ADYQVGKVYV LPKHLDEKVA RLHLKKVGAM
460 470
LTELTDEQAA YIGVSKSGPY KADTYRY
Length:477
Mass (Da):51,937
Last modified:March 6, 2007 - v1
Checksum:i3A8BE09B0DA93386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM96239.1.
RefSeqiWP_011830862.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM96239; ABM96239; Mpe_A3286.
KEGGimpt:Mpe_A3286.

Similar proteinsi

Entry informationi

Entry nameiSAHH_METPP
AccessioniPrimary (citable) accession number: A2SL00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 6, 2007
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families