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A2SK02 (A2SK02_METPP) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 1 HAMAP MF_00051
Short name=SHMT 1 HAMAP MF_00051
Short name=Serine methylase 1 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA1 HAMAP MF_00051
Ordered Locus Names:Mpe_A2938
OrganismMethylibium petroleiphilum (strain PM1) [Complete proteome] [HAMAP] EMBL ABM95891.1
Taxonomic identifier420662 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Methylibium

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2351N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
A2SK02 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 32B4B26F5E5695A1

FASTA42145,734
        10         20         30         40         50         60 
MRTATMFDRQ QSTVANVDAE LWAAIQAENR RQEEHIELIA SENYASPAVM AAQGTQLTNK 

        70         80         90        100        110        120 
YAEGYPGKRY YGGCENVDVV EQLAIDRLKQ LYGAAFANVQ PNSGSQANQG AFFALLQPGD 

       130        140        150        160        170        180 
TIMGMSLAEG GHLTHGMALN MSGKWFKVVS YGLDAKEEID YDAMERLAHE HKPKLIIAGA 

       190        200        210        220        230        240 
SAYALRIDFE RFAKVAKAVG AYFMVDMAHY AGLIAAGVYP NPVPFADVVT STTHKSLRGP 

       250        260        270        280        290        300 
RGGIILANNE DIAKKINSAI FPGLQGGPLM HVIAAKAVAF KEALQPEFKA YQQQVVKNAD 

       310        320        330        340        350        360 
ALARTLTERG LRIVSGRTES HVMLVDLRPK GLTGKEAEAI LGQAHMTCNK NGIPNDPQKP 

       370        380        390        400        410        420 
MVTSGIRLGS PAMTTRGFGV EQAVRTAHLI ADVLDRPHDE SNLADVRAKV ALLTREFPVY 


R

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References

[1]"Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
J. Bacteriol. 189:1931-1945(2007) [PubMed: 17158667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000555 Genomic DNA. Translation: ABM95891.1.
RefSeqYP_001022126.1. NC_008825.1.

3D structure databases

ProteinModelPortalA2SK02.
SMRA2SK02. Positions 9-420.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2SK02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4784360.
GenomeReviewsGene locus Mpe_A2938 in contig CP000555_GR.
KEGGmpt:Mpe_A2938.
NMPDRfig|279263.3.peg.3024.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMARIDFERI.
PhylomeDBA2SK02.
ProtClustDBPRK00011.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2SK02_METPP
AccessionPrimary (citable) accession number: A2SK02
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info