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A2SJR5

- TRMB_METPP

UniProt

A2SJR5 - TRMB_METPP

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei287 – 2871S-adenosyl-L-methionineBy similarity
Binding sitei312 – 3121S-adenosyl-L-methionineBy similarity
Binding sitei339 – 3391S-adenosyl-L-methionineBy similarity
Active sitei362 – 3621By similarity
Binding sitei362 – 3621S-adenosyl-L-methionineBy similarity
Binding sitei366 – 3661SubstrateBy similarity
Binding sitei398 – 3981SubstrateBy similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMPET420662:GHBE-2884-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Mpe_A2850
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469tRNA (guanine-N(7)-)-methyltransferasePRO_0000288178Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A2850.

Structurei

3D structure databases

ProteinModelPortaliA2SJR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 221221UnknownAdd
BLAST
Regioni222 – 469248tRNA (guanine-N(7)-)-methyltransferaseAdd
BLAST
Regioni433 – 4364Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SJR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGGAHGPGD RAGRCREHRQ DHAGPCAGAG APFARPAGHA GGRVPARVLR
60 70 80 90 100
RARPHAAARG TGRHRRRAMA SHRGRRAGRS HRAGRHHAAD DRGLQRVRVR
110 120 130 140 150
RPQSLPPGAR APAPLRPHAA DRPRPGLAAR RPAARRRPGA RPGRPLGPRR
160 170 180 190 200
AGLCRAALFG GLWRRLGAHG SRCGCAAPAA APARPGGPRA RRPAAAWPLP
210 220 230 240 250
RMPAARMRTS VVRVRGEAPI AMSEPDSSSP PAHPPRPIRS FVLRAGRMGS
260 270 280 290 300
GQTRALAELG PRFVLPFQRE PLDPQTVFGR RAPRVFEIGF GMGDATAQIA
310 320 330 340 350
AARPDTDFIG CEVHTPGVGA LLKQIGEREL TNLRIVQHDA VEVLDHMIEP
360 370 380 390 400
GSLAGIHLFF PDPWHKKKHH KRRLVQPAFV ERLVTRLAPG GYLHCATDWQ
410 420 430 440 450
PYAEQMLEVL GAEPALRNSA DGYAPRPEYR PLTKFEQRGL RLGHGVWDLV
460
FTKHQGRSAS KQCTATSSP
Length:469
Mass (Da):50,968
Last modified:March 6, 2007 - v1
Checksum:iE173CAD6CD3C08D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM95804.1.
RefSeqiYP_001022039.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM95804; ABM95804; Mpe_A2850.
GeneIDi4785544.
KEGGimpt:Mpe_A2850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM95804.1 .
RefSeqi YP_001022039.1. NC_008825.1.

3D structure databases

ProteinModelPortali A2SJR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A2850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM95804 ; ABM95804 ; Mpe_A2850 .
GeneIDi 4785544.
KEGGi mpt:Mpe_A2850.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MPET420662:GHBE-2884-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiTRMB_METPP
AccessioniPrimary (citable) accession number: A2SJR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 6, 2007
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3