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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase (Mpe_A1074)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei160May be catalytically important1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Mpe_A2630
OrganismiMethylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
Proteomesi
  • UP000000366 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002894971 – 297GTP cyclohydrolase FolE2Add BLAST297

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A2630.

Structurei

3D structure databases

SMRiA2SJ45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiPOG091H0MIO.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445. PTHR36445. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SJ45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHASALGLT QHIPDTQSER DERHLAIQRV GVKEVRYPLT VRIGEQLSPT
60 70 80 90 100
VASWSLDVAL PAEQKGTHMS RFVAWLDALS ASGKPLDATA LRDELAVMLD
110 120 130 140 150
KLHAVEGRIE ARFPFFIRKH APVSGVSSLL DYQGAWIAEH RAGSGTTVWC
160 170 180 190 200
EVVVPVKSLC PCSKEISDYG AHNQRSHVTI RAELMEPPGD RRRPPPPGGG
210 220 230 240 250
ESTRERPVVD SAVELGFEAL VRFAEASASS EIWGLLKRPD EKWITERAYE
260 270 280 290
NPKFVEDLVR DVALRLNADA RIGRYRVEVE NFESIHNHSA FAVIERE
Length:297
Mass (Da):33,097
Last modified:May 5, 2009 - v2
Checksum:iD340256820BB2C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM95584.1.

Genome annotation databases

EnsemblBacteriaiABM95584; ABM95584; Mpe_A2630.
KEGGimpt:Mpe_A2630.

Similar proteinsi

Entry informationi

Entry nameiGCH4_METPP
AccessioniPrimary (citable) accession number: A2SJ45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families