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A2SJ45

- GCH4_METPP

UniProt

A2SJ45 - GCH4_METPP

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Mpe_A2630
Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei160 – 1601May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMPET420662:GHBE-2662-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Mpe_A2630
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289497Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A2630.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SJ45-1 [UniParc]FASTAAdd to Basket

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MTHASALGLT QHIPDTQSER DERHLAIQRV GVKEVRYPLT VRIGEQLSPT    50
VASWSLDVAL PAEQKGTHMS RFVAWLDALS ASGKPLDATA LRDELAVMLD 100
KLHAVEGRIE ARFPFFIRKH APVSGVSSLL DYQGAWIAEH RAGSGTTVWC 150
EVVVPVKSLC PCSKEISDYG AHNQRSHVTI RAELMEPPGD RRRPPPPGGG 200
ESTRERPVVD SAVELGFEAL VRFAEASASS EIWGLLKRPD EKWITERAYE 250
NPKFVEDLVR DVALRLNADA RIGRYRVEVE NFESIHNHSA FAVIERE 297
Length:297
Mass (Da):33,097
Last modified:May 5, 2009 - v2
Checksum:iD340256820BB2C08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM95584.1.
RefSeqiYP_001021819.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM95584; ABM95584; Mpe_A2630.
GeneIDi4785855.
KEGGimpt:Mpe_A2630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM95584.1 .
RefSeqi YP_001021819.1. NC_008825.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A2630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM95584 ; ABM95584 ; Mpe_A2630 .
GeneIDi 4785855.
KEGGi mpt:Mpe_A2630.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci MPET420662:GHBE-2662-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiGCH4_METPP
AccessioniPrimary (citable) accession number: A2SJ45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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