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A2SFU2

- LFTR_METPP

UniProt

A2SFU2 - LFTR_METPP

Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

    Catalytic activityi

    L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
    L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

    GO - Molecular functioni

    1. leucyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMPET420662:GHBE-1490-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
    Alternative name(s):
    L/F-transferaseUniRule annotation
    LeucyltransferaseUniRule annotation
    PhenyalanyltransferaseUniRule annotation
    Gene namesi
    Name:aatUniRule annotation
    Ordered Locus Names:Mpe_A1469
    OrganismiMethylibium petroleiphilum (strain PM1)
    Taxonomic identifieri420662 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
    ProteomesiUP000000366: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Leucyl/phenylalanyl-tRNA--protein transferasePRO_0000304343Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi420662.Mpe_A1469.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SFU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L/F-transferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2360.
    HOGENOMiHOG000102325.
    KOiK00684.
    OMAiWSPDPRG.
    OrthoDBiEOG6WX4R3.

    Family and domain databases

    HAMAPiMF_00688. Leu_Phe_trans.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view]
    PfamiPF03588. Leu_Phe_trans. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR00667. aat. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2SFU2-1 [UniParc]FASTAAdd to Basket

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    MPTWLASPDD PLPDTRHALP AGSEVPGLVA AGTDLSPRRL AEAYARGIFP    50
    WYSAGQPVLW WSPDPRMVLP VAEFKLSHSL RKTLRRFSAA PHCEVRIDHD 100
    FAAVIHACAT TPREGQDGTW IQPELQAAYT EWHRLGAVHS FETWVDGRLL 150
    GGLYGVNLGR MFFGESMFSH ATDASKIALA ALVAFCRAND IALIDCQQRT 200
    AHLGSLGARE IDRPAFEGHL ARTVAQRPPE DWTYHRSHWT QLRLDTGPDP 250
    ASSSVTEISL RPAAP 265
    Length:265
    Mass (Da):29,244
    Last modified:March 6, 2007 - v1
    Checksum:iDABBFA5244DC4CEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM94431.1.
    RefSeqiYP_001020666.1. NC_008825.1.

    Genome annotation databases

    EnsemblBacteriaiABM94431; ABM94431; Mpe_A1469.
    GeneIDi4784067.
    KEGGimpt:Mpe_A1469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM94431.1 .
    RefSeqi YP_001020666.1. NC_008825.1.

    3D structure databases

    ProteinModelPortali A2SFU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420662.Mpe_A1469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM94431 ; ABM94431 ; Mpe_A1469 .
    GeneIDi 4784067.
    KEGGi mpt:Mpe_A1469.

    Phylogenomic databases

    eggNOGi COG2360.
    HOGENOMi HOG000102325.
    KOi K00684.
    OMAi WSPDPRG.
    OrthoDBi EOG6WX4R3.

    Enzyme and pathway databases

    BioCyci MPET420662:GHBE-1490-MONOMER.

    Family and domain databases

    HAMAPi MF_00688. Leu_Phe_trans.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view ]
    Pfami PF03588. Leu_Phe_trans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR00667. aat. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
      Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
      J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PM1.

    Entry informationi

    Entry nameiLFTR_METPP
    AccessioniPrimary (citable) accession number: A2SFU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3