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A2SEL8 (UPPP_METPP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Mpe_A1046
OrganismMethylibium petroleiphilum (strain PM1) [Complete proteome] [HAMAP]
Taxonomic identifier420662 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290727

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane260 – 28021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A2SEL8 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 0062AE9A38F46F0A

FASTA28531,022
        10         20         30         40         50         60 
MDILLLVKAA IMGIVEGLTE FLPISSTGHL ILTASLLNFT GEIVKVFDIA IQTGAMFAVI 

        70         80         90        100        110        120 
WEYRVRLRAT VAGITHEAVA QRFVRNLLIA FVPAVISGLA LGGLIKEHLF HPVPVATAFV 

       130        140        150        160        170        180 
VGGLIILWVE RRHRALFGDR DLEGGRVARV ETIDDMSALD ALKVGLVQCA ALIPGTSRSG 

       190        200        210        220        230        240 
ATIIGAMLFG FSRKAATEFS FFLGIPTLMG AGAYSLIKQR DLLSWGDLPV FAVGVVFAFL 

       250        260        270        280 
SALVCIRWLI RYVSTHDFTV FAWYRIAFGG LVLLSAWGGW VDWKD 

« Hide

References

[1]"Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000555 Genomic DNA. Translation: ABM94007.1.
RefSeqYP_001020242.1. NC_008825.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420662.Mpe_A1046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM94007; ABM94007; Mpe_A1046.
GeneID4785649.
KEGGmpt:Mpe_A1046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMPET420662:GHBE-1055-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_METPP
AccessionPrimary (citable) accession number: A2SEL8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families