A2SEL8 (UPPP_METPP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Mpe_A1046

Organism

Methylibium petroleiphilum (strain PM1) [Complete proteome] [HAMAP]

Taxonomic identifier

420662 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › unclassified Burkholderiales › Burkholderiales Genera incertae sedis › Methylibium › Methylibium petroleiphilum

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290727
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A2SEL8 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 0062AE9A38F46F0A	FASTA	285	31,022
	10 20 30 40 50 60 MDILLLVKAA IMGIVEGLTE FLPISSTGHL ILTASLLNFT GEIVKVFDIA IQTGAMFAVI 70 80 90 100 110 120 WEYRVRLRAT VAGITHEAVA QRFVRNLLIA FVPAVISGLA LGGLIKEHLF HPVPVATAFV 130 140 150 160 170 180 VGGLIILWVE RRHRALFGDR DLEGGRVARV ETIDDMSALD ALKVGLVQCA ALIPGTSRSG 190 200 210 220 230 240 ATIIGAMLFG FSRKAATEFS FFLGIPTLMG AGAYSLIKQR DLLSWGDLPV FAVGVVFAFL 250 260 270 280 SALVCIRWLI RYVSTHDFTV FAWYRIAFGG LVLLSAWGGW VDWKD

References

[1]

"Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1." Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R. J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000555 Genomic DNA. Translation: ABM94007.1.
RefSeq	YP_001020242.1. NC_008825.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	420662.Mpe_A1046.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM94007; ABM94007; Mpe_A1046.
GeneID	4785649.
KEGG	mpt:Mpe_A1046.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
Enzyme and pathway databases
BioCyc	MPET420662:GHBE-1761-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_METPP

Accession

Primary (citable) accession number: A2SEL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program