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A2SE10

- HIS3_METPP

UniProt

A2SE10 - HIS3_METPP

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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene
hisI, Mpe_A0837
Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP By similarity.

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Magnesium By similarity
Metal bindingi77 – 771Zinc; shared with dimeric partner By similarity
Metal bindingi78 – 781Magnesium By similarity
Metal bindingi80 – 801Magnesium By similarity
Metal bindingi97 – 971Zinc; shared with dimeric partner By similarity
Metal bindingi104 – 1041Zinc; shared with dimeric partner By similarity

GO - Molecular functioni

  1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMPET420662:GHBE-845-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Gene namesi
Name:hisI
Ordered Locus Names:Mpe_A0837
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Phosphoribosyl-AMP cyclohydrolaseUniRule annotationPRO_0000319699Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi420662.Mpe_A0837.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.

Phylogenomic databases

eggNOGiCOG0139.
HOGENOMiHOG000277504.
KOiK01496.
OMAiHEPGIAC.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A2SE10-1 [UniParc]FASTAAdd to Basket

« Hide

MTWLDDIRWD RDGLLPVIAQ EAATGDVLMF AWMNREALAR TAELGEAVYW    50
SRSRGRLWHK GEESGHIQKV RDMRLDCDND VLLLKVEQLG HEPSIACHTG 100
RHSCFYQRYE SGAWHAVELV LKDPEHIYR 129
Length:129
Mass (Da):15,032
Last modified:March 6, 2007 - v1
Checksum:i2FAED33533799D3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM93799.1.
RefSeqiWP_011828437.1. NC_008825.1.
YP_001020034.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM93799; ABM93799; Mpe_A0837.
GeneIDi4786972.
KEGGimpt:Mpe_A0837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM93799.1 .
RefSeqi WP_011828437.1. NC_008825.1.
YP_001020034.1. NC_008825.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A0837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM93799 ; ABM93799 ; Mpe_A0837 .
GeneIDi 4786972.
KEGGi mpt:Mpe_A0837.

Phylogenomic databases

eggNOGi COG0139.
HOGENOMi HOG000277504.
KOi K01496.
OMAi HEPGIAC.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci MPET420662:GHBE-845-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiHIS3_METPP
AccessioniPrimary (citable) accession number: A2SE10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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