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A2SE10

- HIS3_METPP

UniProt

A2SE10 - HIS3_METPP

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761MagnesiumUniRule annotation
    Metal bindingi77 – 771Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi78 – 781MagnesiumUniRule annotation
    Metal bindingi80 – 801MagnesiumUniRule annotation
    Metal bindingi97 – 971Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi104 – 1041Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMPET420662:GHBE-845-MONOMER.
    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:Mpe_A0837
    OrganismiMethylibium petroleiphilum (strain PM1)
    Taxonomic identifieri420662 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
    ProteomesiUP000000366: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Phosphoribosyl-AMP cyclohydrolasePRO_0000319699Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi420662.Mpe_A0837.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    HOGENOMiHOG000277504.
    KOiK01496.
    OMAiHEPGIAC.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    A2SE10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWLDDIRWD RDGLLPVIAQ EAATGDVLMF AWMNREALAR TAELGEAVYW    50
    SRSRGRLWHK GEESGHIQKV RDMRLDCDND VLLLKVEQLG HEPSIACHTG 100
    RHSCFYQRYE SGAWHAVELV LKDPEHIYR 129
    Length:129
    Mass (Da):15,032
    Last modified:March 6, 2007 - v1
    Checksum:i2FAED33533799D3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM93799.1.
    RefSeqiWP_011828437.1. NC_008825.1.
    YP_001020034.1. NC_008825.1.

    Genome annotation databases

    EnsemblBacteriaiABM93799; ABM93799; Mpe_A0837.
    GeneIDi4786972.
    KEGGimpt:Mpe_A0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM93799.1 .
    RefSeqi WP_011828437.1. NC_008825.1.
    YP_001020034.1. NC_008825.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420662.Mpe_A0837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM93799 ; ABM93799 ; Mpe_A0837 .
    GeneIDi 4786972.
    KEGGi mpt:Mpe_A0837.

    Phylogenomic databases

    eggNOGi COG0139.
    HOGENOMi HOG000277504.
    KOi K01496.
    OMAi HEPGIAC.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .
    BioCyci MPET420662:GHBE-845-MONOMER.

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
      Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
      J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PM1.

    Entry informationi

    Entry nameiHIS3_METPP
    AccessioniPrimary (citable) accession number: A2SE10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3