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A2SC91

- SYL_METPP

UniProt

A2SC91 - SYL_METPP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei657 – 6571ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPET420662:GHBE-218-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mpe_A0218
    OrganismiMethylibium petroleiphilum (strain PM1)
    Taxonomic identifieri420662 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
    ProteomesiUP000000366: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 897897Leucine--tRNA ligasePRO_0000334771Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi420662.Mpe_A0218.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SC91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 5911"HIGH" regionAdd
    BLAST
    Motifi654 – 6585"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2SC91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPHPAPAS AYEPGAIEAA AHAHWTARDA HRVVEDTSRP KFYACSMLPY    50
    PSGKLHMGHV RNYTINDMMA RYLRMKGYNV LMPMGWDAFG LPAENAAIDK 100
    KVAPAQWTRD NIADMKSQMQ PLGLAFDWSR EVATCDPDYY KWNQWFFLKL 150
    LEKGIAYKKT QVVNWDPVDQ TVLANEQVID GRGWRSGAPV ERREIPGYYL 200
    AITQYADELL ANVADPASPG FLHGWPERVR LMQEHWIGKS AGVRFAFPHE 250
    IRDADGTLVG DGLMHVFTTR ADTIMGVTFC AVAPEHPLAT HAAASDPDLA 300
    AFIETCKAGG TTEAELATKD KEGRPTGLFV KHPLSGAPVP VWVGNYVLMG 350
    YGDGAVMGVP AHDERDFAFA KKYGIDILQV VHVDGEHFSY DHWQDWYADK 400
    QRGVTINSGN LSGLSYPVAV DAVAAALAAQ GLGDKKTTWR LRDWGISRQR 450
    YWGTPIPIIH CTGSGPGSDN PGCGDVPVPE QDLPVLLPED LIPDGSGNPL 500
    NKSAAFLNVA CPKCGAPAKR ETDTMDTFVD SSWYYMRYCC PDSDAAMVDS 550
    RNDYWMPMDQ YIGGIEHAVL HLLYARFWTK AMRDCGLVKF DEPFTKLFTQ 600
    GMLLNESYYR EDASGKKRWF YPSEVEVQFD DKGHPVGAIA REDGQPVQLG 650
    GIEKMSKSKN NVVEPRDIIA KFGADTARLF TMFAGPPDQS AAWSDSGAEG 700
    SFRYLRRLWA FATKQREAVQ AAGTDFADAS RAAIDLRRDV HLLLRQVSHD 750
    YDRLQYNTVV SGAMKLLNAL ESAALADTAA DRAALREGLG ILLRALYPAA 800
    PHIAHALWQD LGYAAAHGDL LDAPWPAVDE QALVQDEIEL VLQVNGKLRG 850
    ALKVPASADR AAIEAAALAS PELAKFAEGR TPKKVVVVPG RLVNVVV 897
    Length:897
    Mass (Da):98,705
    Last modified:March 6, 2007 - v1
    Checksum:i1C9F65043FCFB22D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM93180.1.
    RefSeqiYP_001019415.1. NC_008825.1.

    Genome annotation databases

    EnsemblBacteriaiABM93180; ABM93180; Mpe_A0218.
    GeneIDi4784003.
    KEGGimpt:Mpe_A0218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000555 Genomic DNA. Translation: ABM93180.1 .
    RefSeqi YP_001019415.1. NC_008825.1.

    3D structure databases

    ProteinModelPortali A2SC91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420662.Mpe_A0218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM93180 ; ABM93180 ; Mpe_A0218 .
    GeneIDi 4784003.
    KEGGi mpt:Mpe_A0218.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MPET420662:GHBE-218-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
      Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
      J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PM1.

    Entry informationi

    Entry nameiSYL_METPP
    AccessioniPrimary (citable) accession number: A2SC91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3