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A2SC91

- SYL_METPP

UniProt

A2SC91 - SYL_METPP

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Protein
Leucine--tRNA ligase
Gene
leuS, Mpe_A0218
Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei657 – 6571ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET420662:GHBE-218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mpe_A0218
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Leucine--tRNA ligaseUniRule annotation
PRO_0000334771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A0218.

Structurei

3D structure databases

ProteinModelPortaliA2SC91.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionUniRule annotation
Add
BLAST
Motifi654 – 6585"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SC91-1 [UniParc]FASTAAdd to Basket

« Hide

MSTPHPAPAS AYEPGAIEAA AHAHWTARDA HRVVEDTSRP KFYACSMLPY    50
PSGKLHMGHV RNYTINDMMA RYLRMKGYNV LMPMGWDAFG LPAENAAIDK 100
KVAPAQWTRD NIADMKSQMQ PLGLAFDWSR EVATCDPDYY KWNQWFFLKL 150
LEKGIAYKKT QVVNWDPVDQ TVLANEQVID GRGWRSGAPV ERREIPGYYL 200
AITQYADELL ANVADPASPG FLHGWPERVR LMQEHWIGKS AGVRFAFPHE 250
IRDADGTLVG DGLMHVFTTR ADTIMGVTFC AVAPEHPLAT HAAASDPDLA 300
AFIETCKAGG TTEAELATKD KEGRPTGLFV KHPLSGAPVP VWVGNYVLMG 350
YGDGAVMGVP AHDERDFAFA KKYGIDILQV VHVDGEHFSY DHWQDWYADK 400
QRGVTINSGN LSGLSYPVAV DAVAAALAAQ GLGDKKTTWR LRDWGISRQR 450
YWGTPIPIIH CTGSGPGSDN PGCGDVPVPE QDLPVLLPED LIPDGSGNPL 500
NKSAAFLNVA CPKCGAPAKR ETDTMDTFVD SSWYYMRYCC PDSDAAMVDS 550
RNDYWMPMDQ YIGGIEHAVL HLLYARFWTK AMRDCGLVKF DEPFTKLFTQ 600
GMLLNESYYR EDASGKKRWF YPSEVEVQFD DKGHPVGAIA REDGQPVQLG 650
GIEKMSKSKN NVVEPRDIIA KFGADTARLF TMFAGPPDQS AAWSDSGAEG 700
SFRYLRRLWA FATKQREAVQ AAGTDFADAS RAAIDLRRDV HLLLRQVSHD 750
YDRLQYNTVV SGAMKLLNAL ESAALADTAA DRAALREGLG ILLRALYPAA 800
PHIAHALWQD LGYAAAHGDL LDAPWPAVDE QALVQDEIEL VLQVNGKLRG 850
ALKVPASADR AAIEAAALAS PELAKFAEGR TPKKVVVVPG RLVNVVV 897
Length:897
Mass (Da):98,705
Last modified:March 6, 2007 - v1
Checksum:i1C9F65043FCFB22D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM93180.1.
RefSeqiYP_001019415.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM93180; ABM93180; Mpe_A0218.
GeneIDi4784003.
KEGGimpt:Mpe_A0218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000555 Genomic DNA. Translation: ABM93180.1 .
RefSeqi YP_001019415.1. NC_008825.1.

3D structure databases

ProteinModelPortali A2SC91.
ModBasei Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A0218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM93180 ; ABM93180 ; Mpe_A0218 .
GeneIDi 4784003.
KEGGi mpt:Mpe_A0218.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MPET420662:GHBE-218-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiSYL_METPP
AccessioniPrimary (citable) accession number: A2SC91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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