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A2SC91

- SYL_METPP

UniProt

A2SC91 - SYL_METPP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylibium petroleiphilum (strain PM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei657 – 6571ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET420662:GHBE-218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mpe_A0218
OrganismiMethylibium petroleiphilum (strain PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
ProteomesiUP000000366: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Leucine--tRNA ligasePRO_0000334771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A0218.

Structurei

3D structure databases

ProteinModelPortaliA2SC91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionAdd
BLAST
Motifi654 – 6585"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SC91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPHPAPAS AYEPGAIEAA AHAHWTARDA HRVVEDTSRP KFYACSMLPY
60 70 80 90 100
PSGKLHMGHV RNYTINDMMA RYLRMKGYNV LMPMGWDAFG LPAENAAIDK
110 120 130 140 150
KVAPAQWTRD NIADMKSQMQ PLGLAFDWSR EVATCDPDYY KWNQWFFLKL
160 170 180 190 200
LEKGIAYKKT QVVNWDPVDQ TVLANEQVID GRGWRSGAPV ERREIPGYYL
210 220 230 240 250
AITQYADELL ANVADPASPG FLHGWPERVR LMQEHWIGKS AGVRFAFPHE
260 270 280 290 300
IRDADGTLVG DGLMHVFTTR ADTIMGVTFC AVAPEHPLAT HAAASDPDLA
310 320 330 340 350
AFIETCKAGG TTEAELATKD KEGRPTGLFV KHPLSGAPVP VWVGNYVLMG
360 370 380 390 400
YGDGAVMGVP AHDERDFAFA KKYGIDILQV VHVDGEHFSY DHWQDWYADK
410 420 430 440 450
QRGVTINSGN LSGLSYPVAV DAVAAALAAQ GLGDKKTTWR LRDWGISRQR
460 470 480 490 500
YWGTPIPIIH CTGSGPGSDN PGCGDVPVPE QDLPVLLPED LIPDGSGNPL
510 520 530 540 550
NKSAAFLNVA CPKCGAPAKR ETDTMDTFVD SSWYYMRYCC PDSDAAMVDS
560 570 580 590 600
RNDYWMPMDQ YIGGIEHAVL HLLYARFWTK AMRDCGLVKF DEPFTKLFTQ
610 620 630 640 650
GMLLNESYYR EDASGKKRWF YPSEVEVQFD DKGHPVGAIA REDGQPVQLG
660 670 680 690 700
GIEKMSKSKN NVVEPRDIIA KFGADTARLF TMFAGPPDQS AAWSDSGAEG
710 720 730 740 750
SFRYLRRLWA FATKQREAVQ AAGTDFADAS RAAIDLRRDV HLLLRQVSHD
760 770 780 790 800
YDRLQYNTVV SGAMKLLNAL ESAALADTAA DRAALREGLG ILLRALYPAA
810 820 830 840 850
PHIAHALWQD LGYAAAHGDL LDAPWPAVDE QALVQDEIEL VLQVNGKLRG
860 870 880 890
ALKVPASADR AAIEAAALAS PELAKFAEGR TPKKVVVVPG RLVNVVV
Length:897
Mass (Da):98,705
Last modified:March 6, 2007 - v1
Checksum:i1C9F65043FCFB22D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM93180.1.
RefSeqiYP_001019415.1. NC_008825.1.

Genome annotation databases

EnsemblBacteriaiABM93180; ABM93180; Mpe_A0218.
GeneIDi4784003.
KEGGimpt:Mpe_A0218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA. Translation: ABM93180.1 .
RefSeqi YP_001019415.1. NC_008825.1.

3D structure databases

ProteinModelPortali A2SC91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420662.Mpe_A0218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM93180 ; ABM93180 ; Mpe_A0218 .
GeneIDi 4784003.
KEGGi mpt:Mpe_A0218.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MPET420662:GHBE-218-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-proteobacterium Methylibium petroleiphilum PM1."
    Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W., Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., Hristova K.R.
    J. Bacteriol. 189:1931-1945(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PM1.

Entry informationi

Entry nameiSYL_METPP
AccessioniPrimary (citable) accession number: A2SC91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3