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A2SA04

- UVRC_BURM9

UniProt

A2SA04 - UVRC_BURM9

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Protein

UvrABC system protein C

Gene

uvrC

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciBMAL412022:GJI8-2824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BMA10229_A2824
OrganismiBurkholderia mallei (strain NCTC 10229)
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002283: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747UvrABC system protein CPRO_1000077760Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi412022.BMA10229_A2824.

Structurei

3D structure databases

ProteinModelPortaliA2SA04.
SMRiA2SA04. Positions 693-747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10079GIY-YIGUniRule annotationAdd
BLAST
Domaini209 – 24436UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279961.
KOiK03703.
OMAiIHQEGGY.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2SA04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSPDAPESR FEPKPILAQL PHLPGVYRYY DVQDAVLYVG KARDLKKRVS
60 70 80 90 100
SYFTKTQLSP RIAMMITRIA RIETTVTRSE AEALLLENNL IKALAPRYNI
110 120 130 140 150
LFRDDKSYPY LKLTGHRFPR MAYYRGAVDK KNQYFGPFPS AWAVRESIQI
160 170 180 190 200
LQRVFQLRTC EDSVFNNRTR PCLLHQIGRC SAPCVGAIGE EDYARDVDNA
210 220 230 240 250
SRFLLGRQGE VMGELERKMH AFAAELKFEQ AAAVRNQMSS LAKVLHQQAI
260 270 280 290 300
DVGGDSDVDI LAVVAQGGRV CVNLAMVRGG RHLGDKAYFP AHVETALALA
310 320 330 340 350
GDIEALAGEG AGDGVQAAAQ PAQAPLATDA DATDAAATEA KTVTAAAAAR
360 370 380 390 400
AGARTAQAAG ARAAASAEGD VERRAEGETH ARADAREAAA LPDGAAAAQE
410 420 430 440 450
ADADVDAAPL ETEVLEAFIA QHYLGNRVPP VLVVSHAPAN RELIDLLVEQ
460 470 480 490 500
AGHKVAVVRQ PQGQKRAWLT MAEQNARLAL ARLLSEQGSQ QARTRSLADV
510 520 530 540 550
LGYESDDLAQ LRIECFDISH TMGEATQASC VVYHHHRMQS SEYRRYNIAG
560 570 580 590 600
ITPGDDYAAM RQVLTRRYEK MVEEAAAEAS ADEAAGIDGN AVHAAASAGR
610 620 630 640 650
LPNVVLIDGG RGQVEIARQV FSELGLDISM LVGVAKGEGR KVGLETLIFA
660 670 680 690 700
DGRAPLELGK ESAALMLVAQ IRDEAHRFAI TGMRAKRAKT RQTSRLEELE
710 720 730 740
GVGAKRRQRL LARFGGLRGV VAASVDELAS VEGISRALAE QIYRQLH
Length:747
Mass (Da):80,836
Last modified:March 6, 2007 - v1
Checksum:i8EB63B0873D50FA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000546 Genomic DNA. Translation: ABN01813.1.
RefSeqiYP_001028773.1. NC_008836.1.

Genome annotation databases

EnsemblBacteriaiABN01813; ABN01813; BMA10229_A2824.
GeneIDi4791755.
KEGGibml:BMA10229_A2824.
PATRICi19136646. VBIBurMal46188_5018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000546 Genomic DNA. Translation: ABN01813.1 .
RefSeqi YP_001028773.1. NC_008836.1.

3D structure databases

ProteinModelPortali A2SA04.
SMRi A2SA04. Positions 693-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412022.BMA10229_A2824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN01813 ; ABN01813 ; BMA10229_A2824 .
GeneIDi 4791755.
KEGGi bml:BMA10229_A2824.
PATRICi 19136646. VBIBurMal46188_5018.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279961.
KOi K03703.
OMAi IHQEGGY.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci BMAL412022:GJI8-2824-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10229.

Entry informationi

Entry nameiUVRC_BURM9
AccessioniPrimary (citable) accession number: A2SA04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3