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Protein

UvrABC system protein C

Gene

uvrC

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BMA10229_A2824
OrganismiBurkholderia mallei (strain NCTC 10229)
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002283 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000777601 – 747UvrABC system protein CAdd BLAST747

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2SA04
SMRiA2SA04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 100GIY-YIGUniRule annotationAdd BLAST79
Domaini209 – 244UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279961
KOiK03703
OMAiLFPIRQC

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

A2SA04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPDAPESR FEPKPILAQL PHLPGVYRYY DVQDAVLYVG KARDLKKRVS
60 70 80 90 100
SYFTKTQLSP RIAMMITRIA RIETTVTRSE AEALLLENNL IKALAPRYNI
110 120 130 140 150
LFRDDKSYPY LKLTGHRFPR MAYYRGAVDK KNQYFGPFPS AWAVRESIQI
160 170 180 190 200
LQRVFQLRTC EDSVFNNRTR PCLLHQIGRC SAPCVGAIGE EDYARDVDNA
210 220 230 240 250
SRFLLGRQGE VMGELERKMH AFAAELKFEQ AAAVRNQMSS LAKVLHQQAI
260 270 280 290 300
DVGGDSDVDI LAVVAQGGRV CVNLAMVRGG RHLGDKAYFP AHVETALALA
310 320 330 340 350
GDIEALAGEG AGDGVQAAAQ PAQAPLATDA DATDAAATEA KTVTAAAAAR
360 370 380 390 400
AGARTAQAAG ARAAASAEGD VERRAEGETH ARADAREAAA LPDGAAAAQE
410 420 430 440 450
ADADVDAAPL ETEVLEAFIA QHYLGNRVPP VLVVSHAPAN RELIDLLVEQ
460 470 480 490 500
AGHKVAVVRQ PQGQKRAWLT MAEQNARLAL ARLLSEQGSQ QARTRSLADV
510 520 530 540 550
LGYESDDLAQ LRIECFDISH TMGEATQASC VVYHHHRMQS SEYRRYNIAG
560 570 580 590 600
ITPGDDYAAM RQVLTRRYEK MVEEAAAEAS ADEAAGIDGN AVHAAASAGR
610 620 630 640 650
LPNVVLIDGG RGQVEIARQV FSELGLDISM LVGVAKGEGR KVGLETLIFA
660 670 680 690 700
DGRAPLELGK ESAALMLVAQ IRDEAHRFAI TGMRAKRAKT RQTSRLEELE
710 720 730 740
GVGAKRRQRL LARFGGLRGV VAASVDELAS VEGISRALAE QIYRQLH
Length:747
Mass (Da):80,836
Last modified:March 6, 2007 - v1
Checksum:i8EB63B0873D50FA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA Translation: ABN01813.1

Genome annotation databases

EnsemblBacteriaiABN01813; ABN01813; BMA10229_A2824
KEGGibml:BMA10229_A2824

Similar proteinsi

Entry informationi

Entry nameiUVRC_BURM9
AccessioniPrimary (citable) accession number: A2SA04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health