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A2SA04 (UVRC_BURM9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:BMA10229_A2824
OrganismBurkholderia mallei (strain NCTC 10229) [Complete proteome] [HAMAP]
Taxonomic identifier412022 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length747 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 747747UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000077760

Regions

Domain22 – 10079GIY-YIG
Domain209 – 24436UVR

Sequences

Sequence LengthMass (Da)Tools
A2SA04 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 8EB63B0873D50FA8

FASTA74780,836
        10         20         30         40         50         60 
MTSPDAPESR FEPKPILAQL PHLPGVYRYY DVQDAVLYVG KARDLKKRVS SYFTKTQLSP 

        70         80         90        100        110        120 
RIAMMITRIA RIETTVTRSE AEALLLENNL IKALAPRYNI LFRDDKSYPY LKLTGHRFPR 

       130        140        150        160        170        180 
MAYYRGAVDK KNQYFGPFPS AWAVRESIQI LQRVFQLRTC EDSVFNNRTR PCLLHQIGRC 

       190        200        210        220        230        240 
SAPCVGAIGE EDYARDVDNA SRFLLGRQGE VMGELERKMH AFAAELKFEQ AAAVRNQMSS 

       250        260        270        280        290        300 
LAKVLHQQAI DVGGDSDVDI LAVVAQGGRV CVNLAMVRGG RHLGDKAYFP AHVETALALA 

       310        320        330        340        350        360 
GDIEALAGEG AGDGVQAAAQ PAQAPLATDA DATDAAATEA KTVTAAAAAR AGARTAQAAG 

       370        380        390        400        410        420 
ARAAASAEGD VERRAEGETH ARADAREAAA LPDGAAAAQE ADADVDAAPL ETEVLEAFIA 

       430        440        450        460        470        480 
QHYLGNRVPP VLVVSHAPAN RELIDLLVEQ AGHKVAVVRQ PQGQKRAWLT MAEQNARLAL 

       490        500        510        520        530        540 
ARLLSEQGSQ QARTRSLADV LGYESDDLAQ LRIECFDISH TMGEATQASC VVYHHHRMQS 

       550        560        570        580        590        600 
SEYRRYNIAG ITPGDDYAAM RQVLTRRYEK MVEEAAAEAS ADEAAGIDGN AVHAAASAGR 

       610        620        630        640        650        660 
LPNVVLIDGG RGQVEIARQV FSELGLDISM LVGVAKGEGR KVGLETLIFA DGRAPLELGK 

       670        680        690        700        710        720 
ESAALMLVAQ IRDEAHRFAI TGMRAKRAKT RQTSRLEELE GVGAKRRQRL LARFGGLRGV 

       730        740 
VAASVDELAS VEGISRALAE QIYRQLH 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000546 Genomic DNA. Translation: ABN01813.1.
RefSeqYP_001028773.1. NC_008836.1.

3D structure databases

ProteinModelPortalA2SA04.
SMRA2SA04. Positions 693-747.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING412022.BMA10229_A2824.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN01813; ABN01813; BMA10229_A2824.
GeneID4791755.
KEGGbml:BMA10229_A2824.
PATRIC19136646. VBIBurMal46188_5018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMAIHQEGGY.
OrthoDBEOG6K13R9.

Enzyme and pathway databases

BioCycBMAL412022:GJI8-2824-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_BURM9
AccessionPrimary (citable) accession number: A2SA04
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families