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A2SA04

- UVRC_BURM9

UniProt

A2SA04 - UVRC_BURM9

Protein

UvrABC system protein C

Gene

uvrC

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. excinuclease ABC activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Enzyme and pathway databases

    BioCyciBMAL412022:GJI8-2824-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein CUniRule annotation
    Short name:
    Protein UvrCUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit CUniRule annotation
    Gene namesi
    Name:uvrCUniRule annotation
    Ordered Locus Names:BMA10229_A2824
    OrganismiBurkholderia mallei (strain NCTC 10229)
    Taxonomic identifieri412022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002283: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747UvrABC system protein CPRO_1000077760Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with UvrB in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi412022.BMA10229_A2824.

    Structurei

    3D structure databases

    ProteinModelPortaliA2SA04.
    SMRiA2SA04. Positions 693-747.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10079GIY-YIGUniRule annotationAdd
    BLAST
    Domaini209 – 24436UVRUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UvrC family.UniRule annotation
    Contains 1 GIY-YIG domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0322.
    HOGENOMiHOG000279961.
    KOiK03703.
    OMAiIHQEGGY.
    OrthoDBiEOG6K13R9.

    Family and domain databases

    Gene3Di3.40.1440.10. 1 hit.
    4.10.860.10. 1 hit.
    HAMAPiMF_00203. UvrC.
    InterProiIPR027299. GIY-YIG_dom.
    IPR000305. GIY-YIG_SF.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR001943. UVR_dom.
    IPR004791. UvrC.
    IPR001162. UvrC_homol_region.
    [Graphical view]
    PfamiPF01541. GIY-YIG. 1 hit.
    PF02151. UVR. 1 hit.
    PF08459. UvrC_HhH_N. 1 hit.
    [Graphical view]
    SMARTiSM00465. GIYc. 1 hit.
    SM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF82771. SSF82771. 1 hit.
    TIGRFAMsiTIGR00194. uvrC. 1 hit.
    PROSITEiPS50164. GIY_YIG. 1 hit.
    PS50151. UVR. 1 hit.
    PS50165. UVRC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2SA04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSPDAPESR FEPKPILAQL PHLPGVYRYY DVQDAVLYVG KARDLKKRVS    50
    SYFTKTQLSP RIAMMITRIA RIETTVTRSE AEALLLENNL IKALAPRYNI 100
    LFRDDKSYPY LKLTGHRFPR MAYYRGAVDK KNQYFGPFPS AWAVRESIQI 150
    LQRVFQLRTC EDSVFNNRTR PCLLHQIGRC SAPCVGAIGE EDYARDVDNA 200
    SRFLLGRQGE VMGELERKMH AFAAELKFEQ AAAVRNQMSS LAKVLHQQAI 250
    DVGGDSDVDI LAVVAQGGRV CVNLAMVRGG RHLGDKAYFP AHVETALALA 300
    GDIEALAGEG AGDGVQAAAQ PAQAPLATDA DATDAAATEA KTVTAAAAAR 350
    AGARTAQAAG ARAAASAEGD VERRAEGETH ARADAREAAA LPDGAAAAQE 400
    ADADVDAAPL ETEVLEAFIA QHYLGNRVPP VLVVSHAPAN RELIDLLVEQ 450
    AGHKVAVVRQ PQGQKRAWLT MAEQNARLAL ARLLSEQGSQ QARTRSLADV 500
    LGYESDDLAQ LRIECFDISH TMGEATQASC VVYHHHRMQS SEYRRYNIAG 550
    ITPGDDYAAM RQVLTRRYEK MVEEAAAEAS ADEAAGIDGN AVHAAASAGR 600
    LPNVVLIDGG RGQVEIARQV FSELGLDISM LVGVAKGEGR KVGLETLIFA 650
    DGRAPLELGK ESAALMLVAQ IRDEAHRFAI TGMRAKRAKT RQTSRLEELE 700
    GVGAKRRQRL LARFGGLRGV VAASVDELAS VEGISRALAE QIYRQLH 747
    Length:747
    Mass (Da):80,836
    Last modified:March 6, 2007 - v1
    Checksum:i8EB63B0873D50FA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000546 Genomic DNA. Translation: ABN01813.1.
    RefSeqiWP_004192853.1. NC_008836.1.
    YP_001028773.1. NC_008836.1.

    Genome annotation databases

    EnsemblBacteriaiABN01813; ABN01813; BMA10229_A2824.
    GeneIDi4791755.
    KEGGibml:BMA10229_A2824.
    PATRICi19136646. VBIBurMal46188_5018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000546 Genomic DNA. Translation: ABN01813.1 .
    RefSeqi WP_004192853.1. NC_008836.1.
    YP_001028773.1. NC_008836.1.

    3D structure databases

    ProteinModelPortali A2SA04.
    SMRi A2SA04. Positions 693-747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412022.BMA10229_A2824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN01813 ; ABN01813 ; BMA10229_A2824 .
    GeneIDi 4791755.
    KEGGi bml:BMA10229_A2824.
    PATRICi 19136646. VBIBurMal46188_5018.

    Phylogenomic databases

    eggNOGi COG0322.
    HOGENOMi HOG000279961.
    KOi K03703.
    OMAi IHQEGGY.
    OrthoDBi EOG6K13R9.

    Enzyme and pathway databases

    BioCyci BMAL412022:GJI8-2824-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1440.10. 1 hit.
    4.10.860.10. 1 hit.
    HAMAPi MF_00203. UvrC.
    InterProi IPR027299. GIY-YIG_dom.
    IPR000305. GIY-YIG_SF.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR001943. UVR_dom.
    IPR004791. UvrC.
    IPR001162. UvrC_homol_region.
    [Graphical view ]
    Pfami PF01541. GIY-YIG. 1 hit.
    PF02151. UVR. 1 hit.
    PF08459. UvrC_HhH_N. 1 hit.
    [Graphical view ]
    SMARTi SM00465. GIYc. 1 hit.
    SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF82771. SSF82771. 1 hit.
    TIGRFAMsi TIGR00194. uvrC. 1 hit.
    PROSITEi PS50164. GIY_YIG. 1 hit.
    PS50151. UVR. 1 hit.
    PS50165. UVRC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 10229.

    Entry informationi

    Entry nameiUVRC_BURM9
    AccessioniPrimary (citable) accession number: A2SA04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3