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Protein

Ribonuclease 3

Gene

rnc

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38MagnesiumUniRule annotation1
Active sitei42UniRule annotation1
Metal bindingi111MagnesiumUniRule annotation1
Active sitei114UniRule annotation1
Metal bindingi114MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:BMA10229_A2815Imported
OrganismiBurkholderia mallei (strain NCTC 10229)Imported
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002283 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA2S9Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 125RNase IIIInterPro annotationAdd BLAST123
Domaini152 – 222DRBMInterPro annotationAdd BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000246809
KOiK03685
OMAiRAAHVEY

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2S9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSQLESRL RYEFRNAELL RQALTHRSHS ATHNERLEFL GDSVLNCAVA
60 70 80 90 100
ALLFQRFGKL DEGDLSRVRA NLVKQQSLYE IAQALNISDG LRLGEGELRS
110 120 130 140 150
GGFRRPSILA DAFEAIIGAV FLDGGFEAAQ GVIKRLYVPI LDHIDPRTLG
160 170 180 190 200
KDAKTLLQEY LQGHKIALPT YTVVATHGAA HNQQFEVECT VPKLDIKVSG
210 220 230 240 250
SGASRRAAEQ AAAKKALDEV TAVAPMLAAK PKRSKSARGA KHVEPEIVPG
260 270 280 290 300
VKGVQEALDL RSPERKERGA NRVAGGEAKG VESKAVDAKH GESRAAQLRA
310 320 330 340 350
DDAKAGETKA GEARASADAK AGAHTHAAAM PAVPEQADDA ARSPATTSVA
360 370 380 390 400
VIRAAHVEHG LDKGEPRASK PAEKTAAATD KPPEKASDKP SPEKTSEKTP
410 420 430 440 450
DKSHEKQLDK SSEPVAEKAL DKTADKPDAA ARLPAETADR PPRARDASSS
460
AEPDLAAAPV RVADAGH
Length:467
Mass (Da):49,574
Last modified:March 6, 2007 - v1
Checksum:iCF06C8BD4E29459C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA Translation: ABN02752.1
RefSeqiWP_004193321.1, NC_008836.1

Genome annotation databases

EnsemblBacteriaiABN02752; ABN02752; BMA10229_A2815
KEGGibml:BMA10229_A2815

Similar proteinsi

Entry informationi

Entry nameiA2S9Z5_BURM9
AccessioniPrimary (citable) accession number: A2S9Z5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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