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A2S9Z5

- A2S9Z5_BURM9

UniProt

A2S9Z5 - A2S9Z5_BURM9

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Protein

Ribonuclease 3

Gene

rnc

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Note: Mg(2+).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381MagnesiumUniRule annotation
Active sitei42 – 421UniRule annotation
Metal bindingi111 – 1111MagnesiumUniRule annotation
Active sitei114 – 1141UniRule annotation
Metal bindingi114 – 1141MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBMAL412022:GJI8-2815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotationSAAS annotation (EC:3.1.26.3UniRule annotationSAAS annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:BMA10229_A2815Imported
OrganismiBurkholderia mallei (strain NCTC 10229)Imported
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002283: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi412022.BMA10229_A2815.

Structurei

3D structure databases

ProteinModelPortaliA2S9Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 125123RNase IIIUniRule annotationAdd
BLAST
Domaini152 – 22271DRBMUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
Contains 1 RNase III domain.UniRule annotation
Contains DRBM (double-stranded RNA-binding) domain.SAAS annotation
Contains RNase III domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0571.
HOGENOMiHOG000246809.
KOiK03685.
OMAiMPPSQLE.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2S9Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLSQLESRL RYEFRNAELL RQALTHRSHS ATHNERLEFL GDSVLNCAVA
60 70 80 90 100
ALLFQRFGKL DEGDLSRVRA NLVKQQSLYE IAQALNISDG LRLGEGELRS
110 120 130 140 150
GGFRRPSILA DAFEAIIGAV FLDGGFEAAQ GVIKRLYVPI LDHIDPRTLG
160 170 180 190 200
KDAKTLLQEY LQGHKIALPT YTVVATHGAA HNQQFEVECT VPKLDIKVSG
210 220 230 240 250
SGASRRAAEQ AAAKKALDEV TAVAPMLAAK PKRSKSARGA KHVEPEIVPG
260 270 280 290 300
VKGVQEALDL RSPERKERGA NRVAGGEAKG VESKAVDAKH GESRAAQLRA
310 320 330 340 350
DDAKAGETKA GEARASADAK AGAHTHAAAM PAVPEQADDA ARSPATTSVA
360 370 380 390 400
VIRAAHVEHG LDKGEPRASK PAEKTAAATD KPPEKASDKP SPEKTSEKTP
410 420 430 440 450
DKSHEKQLDK SSEPVAEKAL DKTADKPDAA ARLPAETADR PPRARDASSS
460
AEPDLAAAPV RVADAGH
Length:467
Mass (Da):49,574
Last modified:March 6, 2007 - v1
Checksum:iCF06C8BD4E29459C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN02752.1.
RefSeqiYP_001028764.1. NC_008836.1.

Genome annotation databases

EnsemblBacteriaiABN02752; ABN02752; BMA10229_A2815.
GeneIDi4791109.
KEGGibml:BMA10229_A2815.
PATRICi19136628. VBIBurMal46188_5009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN02752.1 .
RefSeqi YP_001028764.1. NC_008836.1.

3D structure databases

ProteinModelPortali A2S9Z5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412022.BMA10229_A2815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN02752 ; ABN02752 ; BMA10229_A2815 .
GeneIDi 4791109.
KEGGi bml:BMA10229_A2815.
PATRICi 19136628. VBIBurMal46188_5009.

Phylogenomic databases

eggNOGi COG0571.
HOGENOMi HOG000246809.
KOi K03685.
OMAi MPPSQLE.
OrthoDBi EOG6T1WVS.

Enzyme and pathway databases

BioCyci BMAL412022:GJI8-2815-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10229Imported.

Entry informationi

Entry nameiA2S9Z5_BURM9
AccessioniPrimary (citable) accession number: A2S9Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3