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A2S9Z5

- A2S9Z5_BURM9

UniProt

A2S9Z5 - A2S9Z5_BURM9

Protein

Ribonuclease 3

Gene

rnc

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

    Cofactori

    Mg2+.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381MagnesiumUniRule annotation
    Active sitei42 – 421UniRule annotation
    Metal bindingi111 – 1111MagnesiumUniRule annotation
    Metal bindingi114 – 1141MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBMAL412022:GJI8-2815-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:BMA10229_A2815Imported
    OrganismiBurkholderia mallei (strain NCTC 10229)Imported
    Taxonomic identifieri412022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002283: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi412022.BMA10229_A2815.

    Structurei

    3D structure databases

    ProteinModelPortaliA2S9Z5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 125123RNase IIIUniRule annotationAdd
    BLAST
    Domaini152 – 22271DRBMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
    Contains 1 RNase III domain.UniRule annotation
    Contains DRBM (double-stranded RNA-binding) domain.SAAS annotation
    Contains RNase III domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    HOGENOMiHOG000246809.
    KOiK03685.
    OMAiMPPSQLE.
    OrthoDBiEOG6T1WVS.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2S9Z5-1 [UniParc]FASTAAdd to Basket

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    MPLSQLESRL RYEFRNAELL RQALTHRSHS ATHNERLEFL GDSVLNCAVA    50
    ALLFQRFGKL DEGDLSRVRA NLVKQQSLYE IAQALNISDG LRLGEGELRS 100
    GGFRRPSILA DAFEAIIGAV FLDGGFEAAQ GVIKRLYVPI LDHIDPRTLG 150
    KDAKTLLQEY LQGHKIALPT YTVVATHGAA HNQQFEVECT VPKLDIKVSG 200
    SGASRRAAEQ AAAKKALDEV TAVAPMLAAK PKRSKSARGA KHVEPEIVPG 250
    VKGVQEALDL RSPERKERGA NRVAGGEAKG VESKAVDAKH GESRAAQLRA 300
    DDAKAGETKA GEARASADAK AGAHTHAAAM PAVPEQADDA ARSPATTSVA 350
    VIRAAHVEHG LDKGEPRASK PAEKTAAATD KPPEKASDKP SPEKTSEKTP 400
    DKSHEKQLDK SSEPVAEKAL DKTADKPDAA ARLPAETADR PPRARDASSS 450
    AEPDLAAAPV RVADAGH 467
    Length:467
    Mass (Da):49,574
    Last modified:March 6, 2007 - v1
    Checksum:iCF06C8BD4E29459C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000546 Genomic DNA. Translation: ABN02752.1.
    RefSeqiYP_001028764.1. NC_008836.1.

    Genome annotation databases

    EnsemblBacteriaiABN02752; ABN02752; BMA10229_A2815.
    GeneIDi4791109.
    KEGGibml:BMA10229_A2815.
    PATRICi19136628. VBIBurMal46188_5009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000546 Genomic DNA. Translation: ABN02752.1 .
    RefSeqi YP_001028764.1. NC_008836.1.

    3D structure databases

    ProteinModelPortali A2S9Z5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412022.BMA10229_A2815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN02752 ; ABN02752 ; BMA10229_A2815 .
    GeneIDi 4791109.
    KEGGi bml:BMA10229_A2815.
    PATRICi 19136628. VBIBurMal46188_5009.

    Phylogenomic databases

    eggNOGi COG0571.
    HOGENOMi HOG000246809.
    KOi K03685.
    OMAi MPPSQLE.
    OrthoDBi EOG6T1WVS.

    Enzyme and pathway databases

    BioCyci BMAL412022:GJI8-2815-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 10229Imported.

    Entry informationi

    Entry nameiA2S9Z5_BURM9
    AccessioniPrimary (citable) accession number: A2S9Z5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3