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Protein

Ribonuclease 3

Gene

rnc

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38MagnesiumUniRule annotation1
Active sitei42UniRule annotation1
Metal bindingi111MagnesiumUniRule annotation1
Active sitei114UniRule annotation1
Metal bindingi114MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:BMA10229_A2815Imported
OrganismiBurkholderia mallei (strain NCTC 10229)Imported
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002283 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA2S9Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 125RNase IIIInterPro annotationAdd BLAST123
Domaini152 – 222DRBM (double-stranded RNA-binding)InterPro annotationAdd BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000246809.
KOiK03685.
OMAiRAAHVEY.

Family and domain databases

CDDicd00593. RIBOc. 1 hit.
Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
PfamiView protein in Pfam
PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2S9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSQLESRL RYEFRNAELL RQALTHRSHS ATHNERLEFL GDSVLNCAVA
60 70 80 90 100
ALLFQRFGKL DEGDLSRVRA NLVKQQSLYE IAQALNISDG LRLGEGELRS
110 120 130 140 150
GGFRRPSILA DAFEAIIGAV FLDGGFEAAQ GVIKRLYVPI LDHIDPRTLG
160 170 180 190 200
KDAKTLLQEY LQGHKIALPT YTVVATHGAA HNQQFEVECT VPKLDIKVSG
210 220 230 240 250
SGASRRAAEQ AAAKKALDEV TAVAPMLAAK PKRSKSARGA KHVEPEIVPG
260 270 280 290 300
VKGVQEALDL RSPERKERGA NRVAGGEAKG VESKAVDAKH GESRAAQLRA
310 320 330 340 350
DDAKAGETKA GEARASADAK AGAHTHAAAM PAVPEQADDA ARSPATTSVA
360 370 380 390 400
VIRAAHVEHG LDKGEPRASK PAEKTAAATD KPPEKASDKP SPEKTSEKTP
410 420 430 440 450
DKSHEKQLDK SSEPVAEKAL DKTADKPDAA ARLPAETADR PPRARDASSS
460
AEPDLAAAPV RVADAGH
Length:467
Mass (Da):49,574
Last modified:March 6, 2007 - v1
Checksum:iCF06C8BD4E29459C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN02752.1.
RefSeqiWP_004193321.1. NC_008836.1.

Genome annotation databases

EnsemblBacteriaiABN02752; ABN02752; BMA10229_A2815.
KEGGibml:BMA10229_A2815.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA2S9Z5_BURM9
AccessioniPrimary (citable) accession number: A2S9Z5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported