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Protein

Kynurenine formamidase

Gene

kynB

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

BioCyciBMAL412022:GJI8-2487-MONOMER.
UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:BMA10229_A2487
OrganismiBurkholderia mallei (strain NCTC 10229)
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002283 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Kynurenine formamidasePRO_0000362107Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA2S926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

A2S926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARVTLSPHTG
60 70 80 90 100
AHADAPLHYD ADGTPIGAVP LDAYLGRCRV IHCIGARSAV TPEHVRAALA
110 120 130 140 150
GAPPRVLLRT YGQAPQHAWD SAFCAVAPET IDLLAAHGVR LVGIDTPSLD
160 170 180 190 200
PQESKTMDAH RRIRAHRMAI LEGLVLDEIA AGDYELIALP LKFATLDASP
210
VRAVLRALPA APR
Length:213
Mass (Da):22,682
Last modified:March 6, 2007 - v1
Checksum:iA1C75BF15C9E6AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN00771.1.
RefSeqiWP_004198883.1. NC_008836.1.

Genome annotation databases

EnsemblBacteriaiABN00771; ABN00771; BMA10229_A2487.
KEGGibml:BMA10229_A2487.
PATRICi19135964. VBIBurMal46188_4685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN00771.1.
RefSeqiWP_004198883.1. NC_008836.1.

3D structure databases

ProteinModelPortaliA2S926.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN00771; ABN00771; BMA10229_A2487.
KEGGibml:BMA10229_A2487.
PATRICi19135964. VBIBurMal46188_4685.

Phylogenomic databases

HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.
BioCyciBMAL412022:GJI8-2487-MONOMER.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKYNB_BURM9
AccessioniPrimary (citable) accession number: A2S926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.