Reviewed, UniProtKB/Swiss-Prot A2S926 (KYNB_BURM9)

Names and origin

Protein names

Recommended name:
    Kynurenine formamidase
      Short name=KFA
    EC=3.5.1.9
Alternative name(s):
    N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BMA10229_A2487

Organism

Burkholderia mallei (strain NCTC 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

412022 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362107

Sequences

	Sequence		Length	Mass (Da)
	A2S926-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: A1C75BF15C9E6AC9	FASTA	213	22,682
	10 20 30 40 50 60 MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARVTLSPHTG AHADAPLHYD 70 80 90 100 110 120 ADGTPIGAVP LDAYLGRCRV IHCIGARSAV TPEHVRAALA GAPPRVLLRT YGQAPQHAWD 130 140 150 160 170 180 SAFCAVAPET IDLLAAHGVR LVGIDTPSLD PQESKTMDAH RRIRAHRMAI LEGLVLDEIA 190 200 210 AGDYELIALP LKFATLDASP VRAVLRALPA APR

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000546 Genomic DNA. Translation: ABN00771.1.
RefSeq	YP_001028445.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4790864.
GenomeReviews	Gene locus BMA10229_A2487 in contig CP000546_GR.
KEGG	bml:BMA10229_A2487.
TIGR	BMA10229_A2487.
Phylogenomic databases
OMA	WPGDTPF.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURM9

Accession

Primary (citable) accession number: A2S926

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	March 6, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)