A2S6D4 (APT_BURM9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	BMA10229_A1521

Organism

Burkholderia mallei (strain NCTC 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

412022 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_0000321345

Sequences

	Sequence		Length	Mass (Da)
	A2S6D4 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 2C980CF31B1DE1A1	FASTA	206	22,225
	10 20 30 40 50 60 MSSDRRTARD CSAVFFGEFH DVHVGRAARS RRVHSQPHPH GAGLAAARRD VSRHHAALQS 70 80 90 100 110 120 AKALRVLVDL FVERYVDAKL DYIAGLDARG FIIAPIVAYE LSVGFVPIRK VGKLPYATQR 130 140 150 160 170 180 ESYALEYGTA TVEIHEDACK PGDRVVIVDD LIATGGTMMA GKNLLERLGA VVVEGAAIVD 190 200 LPDLGGSALL REAGLPLYTV TEFPGH

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 10229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000546 Genomic DNA. No translation available.
RefSeq	YP_001027503.1. NC_008836.1.
3D structure databases
ProteinModelPortal	A2S6D4.
ModBase	Search...
Protein-protein interaction databases
STRING	A2S6D4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4792532.
GenomeReviews	Gene locus BMA10229_A1521 in contig CP000546_GR.
KEGG	bml:BMA10229_A1521.
PATRIC	19133998. VBIBurMal46188_3717.
TIGR	BMA10229_A1521.
Phylogenomic databases
HOGENOM	HBG703830.
OMA	RERLNGK.
PhylomeDB	A2S6D4.
ProtClustDB	PRK02304.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BURM9

Accession

Primary (citable) accession number: A2S6D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 6, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program