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Protein

Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene

citG

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. triphosphoribosyl-dephospho-CoA synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAL412022:GJI8-609-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseUniRule annotation (EC:2.4.2.52UniRule annotation)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthaseUniRule annotation
Gene namesi
Name:citGImported
Synonyms:mdcBUniRule annotation
Ordered Locus Names:BMA10229_A0609Imported
OrganismiBurkholderia mallei (strain NCTC 10229)Imported
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002283 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi412022.BMA10229_A0609.

Family & Domainsi

Sequence similaritiesi

Belongs to the CitG/MdcB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1767.
HOGENOMiHOG000227257.
KOiK13930.
OrthoDBiEOG6WHNRS.

Family and domain databases

HAMAPiMF_01883. MdcB.
InterProiIPR002736. CitG.
IPR017555. TriPribosyl-deP-CoA_syn.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03132. malonate_mdcB. 1 hit.

Sequencei

Sequence statusi: Complete.

A2S3T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMKRHACAV AKPARRDAMC RDRARALDDG GGADTLLDAL DASGVSNASS
60 70 80 90 100
SMGAGDASNR PNIAAVSSIW ASQYFPPATR NASDGADARD SRGRRRHPTF
110 120 130 140 150
AAHRLASLTA TATATATATA AATPASIPTP TPRPTSTATP TPTATAIAAN
160 170 180 190 200
AVRCLRVEID TWPKPGLVSH VDAGSHDDMT ADTFYRSAAA LAPFFAELAD
210 220 230 240 250
AGARDAGMPA LRKIGLRAER AMLAATGGVN THRGAIFGLG LLCAAAGLRG
260 270 280 290 300
SRERRAQRGQ AAGATLGDLV AARWGDEIAG GPRAADSHGA RAARRYGAGG
310 320 330 340 350
ARAEAAGGFA RVYAVGVPAL RDGARRARGD AEAARVHACF ALIAALDDDT
360 370 380 390 400
NLLHRGGRDG LDFAQRTARE FLAAGGVGAC DWRARAAAAH RAFVARRLSP
410 420
GGAADLLAMS LFVVALDDAR ALP
Length:423
Mass (Da):43,283
Last modified:December 15, 2009 - v2
Checksum:i0A855B453B9AD293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN01131.2.
RefSeqiYP_001026604.1. NC_008836.1.

Genome annotation databases

EnsemblBacteriaiABN01131; ABN01131; BMA10229_A0609.
KEGGibml:BMA10229_A0609.
PATRICi19132124. VBIBurMal46188_2784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA. Translation: ABN01131.2.
RefSeqiYP_001026604.1. NC_008836.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi412022.BMA10229_A0609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN01131; ABN01131; BMA10229_A0609.
KEGGibml:BMA10229_A0609.
PATRICi19132124. VBIBurMal46188_2784.

Phylogenomic databases

eggNOGiCOG1767.
HOGENOMiHOG000227257.
KOiK13930.
OrthoDBiEOG6WHNRS.

Enzyme and pathway databases

BioCyciBMAL412022:GJI8-609-MONOMER.

Family and domain databases

HAMAPiMF_01883. MdcB.
InterProiIPR002736. CitG.
IPR017555. TriPribosyl-deP-CoA_syn.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03132. malonate_mdcB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10229Imported.

Entry informationi

Entry nameiA2S3T5_BURM9
AccessioniPrimary (citable) accession number: A2S3T5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: December 15, 2009
Last modified: April 1, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.