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A2S0N7

- GCH4_BURM9

UniProt

A2S0N7 - GCH4_BURM9

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBMAL412022:GJI8-5114-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:BMA10229_1706
    OrganismiBurkholderia mallei (strain NCTC 10229)
    Taxonomic identifieri412022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002283: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269GTP cyclohydrolase FolE2PRO_1000068661Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi412022.BMA10229_1706.

    Structurei

    3D structure databases

    ProteinModelPortaliA2S0N7.
    SMRiA2S0N7. Positions 21-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000012986.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2S0N7-1 [UniParc]FASTAAdd to Basket

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    MNLMNPEFAM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG    50
    TWNLDVHLPA DQKGTHMSRF VALLEERGGP LTADAFRTML ATMLEKLEAR 100
    AGRIEVSFPY FVNKTAPVSG VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV 150
    TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DVPVEDLIRI AEEEASCELW 200
    GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV AYVLEAENFE 250
    SIHNHSAYAL IERDKRRGA 269
    Length:269
    Mass (Da):30,188
    Last modified:March 6, 2007 - v1
    Checksum:i832F04704D584F29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000545 Genomic DNA. Translation: ABM99271.2.
    RefSeqiYP_001025506.1. NC_008835.1.

    Genome annotation databases

    EnsemblBacteriaiABM99271; ABM99271; BMA10229_1706.
    GeneIDi4789421.
    KEGGibml:BMA10229_1707.
    PATRICi19129873. VBIBurMal46188_1667.
    19129875. VBIBurMal46188_1668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000545 Genomic DNA. Translation: ABM99271.2 .
    RefSeqi YP_001025506.1. NC_008835.1.

    3D structure databases

    ProteinModelPortali A2S0N7.
    SMRi A2S0N7. Positions 21-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412022.BMA10229_1706.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM99271 ; ABM99271 ; BMA10229_1706 .
    GeneIDi 4789421.
    KEGGi bml:BMA10229_1707.
    PATRICi 19129873. VBIBurMal46188_1667.
    19129875. VBIBurMal46188_1668.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000012986.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BMAL412022:GJI8-5114-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 10229.

    Entry informationi

    Entry nameiGCH4_BURM9
    AccessioniPrimary (citable) accession number: A2S0N7
    Secondary accession number(s): A2S0N6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3