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A2S0N7 (GCH4_BURM9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BMA10229_1706
OrganismBurkholderia mallei (strain NCTC 10229) [Complete proteome] [HAMAP]
Taxonomic identifier412022 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_1000068661

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A2S0N7 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 832F04704D584F29

FASTA26930,188
        10         20         30         40         50         60 
MNLMNPEFAM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG TWNLDVHLPA 

        70         80         90        100        110        120 
DQKGTHMSRF VALLEERGGP LTADAFRTML ATMLEKLEAR AGRIEVSFPY FVNKTAPVSG 

       130        140        150        160        170        180 
VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV TSLCPCSKKI SQYGAHNQRS HVTIDAELAA 

       190        200        210        220        230        240 
DVPVEDLIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV 

       250        260 
AYVLEAENFE SIHNHSAYAL IERDKRRGA 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000545 Genomic DNA. Translation: ABM99271.2.
RefSeqYP_001025506.1. NC_008835.1.

3D structure databases

ProteinModelPortalA2S0N7.
SMRA2S0N7. Positions 21-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING412022.BMA10229_1706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM99271; ABM99271; BMA10229_1706.
GeneID4789421.
KEGGbml:BMA10229_1707.
PATRIC19129873. VBIBurMal46188_1667.
19129875. VBIBurMal46188_1668.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000012986.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycBMAL412022:GJI8-5114-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BURM9
AccessionPrimary (citable) accession number: A2S0N7
Secondary accession number(s): A2S0N6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways