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Protein

Agamous-like MADS-box protein AGL16

Gene

AGL16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: TAIR
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • stomatal lineage progression Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Agamous-like MADS-box protein AGL16
Gene namesi
Name:AGL16
Ordered Locus Names:At3g57230
ORF Names:F28O9.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G57230.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Agamous-like MADS-box protein AGL16PRO_0000412530Add
BLAST

Proteomic databases

PaxDbiA2RVQ5.
PRIDEiA2RVQ5.

Expressioni

Tissue specificityi

Expressed at high levels in leaves, moderate levels in roots, seedlings and stems, and at low levels in flowers, pollen and siliques. Accumulates in leaf guard cells and trichomes. Also present in epidermal cells of roots.3 Publications

Inductioni

Repressed by the micro RNA miR824.1 Publication

Gene expression databases

ExpressionAtlasiA2RVQ5. baseline and differential.
GenevisibleiA2RVQ5. AT.

Interactioni

Subunit structurei

Homodimer. Interacts with AGL15, AGL24, AP1, AGL6, AG, AGL1, AGL11, AGL5, SEP3, SEP1, AGL63, AGL14, SOC1 and AGL21.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi10206. 23 interactions.
IntActiA2RVQ5. 19 interactions.
STRINGi3702.AT3G57230.1.

Structurei

3D structure databases

ProteinModelPortaliA2RVQ5.
SMRiA2RVQ5. Positions 2-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6161MADS-boxPROSITE-ProRule annotationAdd
BLAST
Domaini86 – 17691K-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 K-box domain.PROSITE-ProRule annotation
Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiA2RVQ5.
OMAiASEIQFW.
PhylomeDBiA2RVQ5.

Family and domain databases

InterProiIPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RVQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRGKIAIKR INNSTSRQVT FSKRRNGLLK KAKELAILCD AEVGVIIFSS
60 70 80 90 100
TGRLYDFSSS SMKSVIERYS DAKGETSSEN DPASEIQFWQ KEAAILKRQL
110 120 130 140 150
HNLQENHRQM MGEELSGLSV EALQNLENQL ELSLRGVRMK KDQMLIEEIQ
160 170 180 190 200
VLNREGNLVH QENLDLHKKV NLMHQQNMEL HEKVSEVEGV KIANKNSLLT
210 220 230 240
NGLDMRDTSN EHVHLQLSQP QHDHETHSKA IQLNYFSFIA
Length:240
Mass (Da):27,428
Last modified:March 6, 2007 - v1
Checksum:i96DDECC135221A3B
GO
Isoform 2 (identifier: A2RVQ5-2) [UniParc]FASTAAdd to basket

Also known as: AGL16-II

The sequence of this isoform differs from the canonical sequence as follows:
     142-240: DQMLIEEIQV...IQLNYFSFIA → VLML

Show »
Length:145
Mass (Da):16,388
Checksum:i2B12ADE2FD115F62
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 24099DQMLI…FSFIA → VLML in isoform 2. 1 PublicationVSP_041688Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY141209 mRNA. Translation: AAN52773.1.
AL137080 Genomic DNA. No translation available.
CP002686 Genomic DNA. Translation: AEE79629.1.
BT030046 mRNA. Translation: ABN04784.1.
AF312662 mRNA. Translation: AAG37899.1.
RefSeqiNP_191282.2. NM_115583.5. [A2RVQ5-1]
UniGeneiAt.21102.

Genome annotation databases

EnsemblPlantsiAT3G57230.1; AT3G57230.1; AT3G57230. [A2RVQ5-1]
GeneIDi824890.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY141209 mRNA. Translation: AAN52773.1.
AL137080 Genomic DNA. No translation available.
CP002686 Genomic DNA. Translation: AEE79629.1.
BT030046 mRNA. Translation: ABN04784.1.
AF312662 mRNA. Translation: AAG37899.1.
RefSeqiNP_191282.2. NM_115583.5. [A2RVQ5-1]
UniGeneiAt.21102.

3D structure databases

ProteinModelPortaliA2RVQ5.
SMRiA2RVQ5. Positions 2-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10206. 23 interactions.
IntActiA2RVQ5. 19 interactions.
STRINGi3702.AT3G57230.1.

Proteomic databases

PaxDbiA2RVQ5.
PRIDEiA2RVQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G57230.1; AT3G57230.1; AT3G57230. [A2RVQ5-1]
GeneIDi824890.

Organism-specific databases

TAIRiAT3G57230.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiA2RVQ5.
OMAiASEIQFW.
PhylomeDBiA2RVQ5.

Miscellaneous databases

PROiA2RVQ5.

Gene expression databases

ExpressionAtlasiA2RVQ5. baseline and differential.
GenevisibleiA2RVQ5. AT.

Family and domain databases

InterProiIPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world."
    Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C., Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C., Colombo L.
    Plant Cell 15:1538-1551(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, GENE FAMILY.
    Strain: cv. Columbia.
    Tissue: Rosette leaf.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "MADS-box gene evolution beyond flowers: expression in pollen, endosperm, guard cells, roots and trichomes."
    Alvarez-Buylla E.R., Liljegren S.J., Pelaz S., Gold S.E., Burgeff C., Ditta G.S., Vergara-Silva F., Yanofsky M.F.
    Plant J. 24:457-466(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-240 (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: cv. Landsberg erecta.
    Tissue: Leaf, Root and Stem.
  6. "Evolution and divergence of the MADS-box gene family based on genome-wide expression analyses."
    Kofuji R., Sumikawa N., Yamasaki M., Kondo K., Ueda K., Ito M., Hasebe M.
    Mol. Biol. Evol. 20:1963-1977(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY.
    Strain: cv. Columbia.
  7. Cited for: INTERACTION WITH AGL15; AGL16; AGL24; AP1; AGL6; AG; AGL1; AGL11; AGL5; SEP3; SEP1; AGL63; AGL14; SOC1 AND AGL21.
  8. "Structurally different alleles of the ath-MIR824 microRNA precursor are maintained at high frequency in Arabidopsis thaliana."
    de Meaux J., Hu J.-Y., Tartler U., Goebel U.
    Proc. Natl. Acad. Sci. U.S.A. 105:8994-8999(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REPRESSION BY MIR824.

Entry informationi

Entry nameiAGL16_ARATH
AccessioniPrimary (citable) accession number: A2RVQ5
Secondary accession number(s): Q7XYY8, Q9FPP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 6, 2007
Last modified: February 17, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.