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Protein

Agamous-like MADS-box protein AGL16

Gene

AGL16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in the regulation of flowering time in long-day photoperiod. Participates in the repression of FT expression and floral transition, by interacting closely with the FLC-SVP pathways (PubMed:24876250). Functions in the satellite meristemoid lineage of stomatal development (PubMed:17704216).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processFlowering, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Agamous-like MADS-box protein AGL16
Gene namesi
Name:AGL16
Ordered Locus Names:At3g57230
ORF Names:F28O9.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:2082618. AT3G57230.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: TAIR

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004125301 – 240Agamous-like MADS-box protein AGL16Add BLAST240

Proteomic databases

PaxDbiA2RVQ5.
PRIDEiA2RVQ5.

Expressioni

Tissue specificityi

Expressed at high levels in leaves, moderate levels in roots, seedlings and stems, and at low levels in flowers, pollen and siliques. Accumulates in leaf guard cells and trichomes. Also present in epidermal cells of roots (PubMed:11115127, PubMed:12837945, PubMed:12949148). Expressed in mature guard cells (PubMed:17704216).4 Publications

Inductioni

Repressed by the micro RNA miR824.1 Publication

Gene expression databases

ExpressionAtlasiA2RVQ5. baseline and differential.
GenevisibleiA2RVQ5. AT.

Interactioni

Subunit structurei

Homodimer. Interacts with AGL15, AGL24, AP1, AGL6, AG, AGL1, AGL11, AGL5, SEP3, SEP1, AGL63, AGL14, SOC1 and AGL21 (PubMed:15805477). Interacts with AGL63 (PubMed:20598091). Interacts with SVP (PubMed:24876250).3 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi10206. 23 interactors.
IntActiA2RVQ5. 19 interactors.
STRINGi3702.AT3G57230.1.

Structurei

3D structure databases

ProteinModelPortaliA2RVQ5.
SMRiA2RVQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxPROSITE-ProRule annotationAdd BLAST61
Domaini86 – 176K-boxPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiA2RVQ5.
OMAiASEIQFW.
OrthoDBiEOG09360MHP.
PhylomeDBiA2RVQ5.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiView protein in InterPro
IPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
PfamiView protein in Pfam
PF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
PRINTSiPR00404. MADSDOMAIN.
SMARTiView protein in SMART
SM00432. MADS. 1 hit.
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiView protein in PROSITE
PS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RVQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRGKIAIKR INNSTSRQVT FSKRRNGLLK KAKELAILCD AEVGVIIFSS
60 70 80 90 100
TGRLYDFSSS SMKSVIERYS DAKGETSSEN DPASEIQFWQ KEAAILKRQL
110 120 130 140 150
HNLQENHRQM MGEELSGLSV EALQNLENQL ELSLRGVRMK KDQMLIEEIQ
160 170 180 190 200
VLNREGNLVH QENLDLHKKV NLMHQQNMEL HEKVSEVEGV KIANKNSLLT
210 220 230 240
NGLDMRDTSN EHVHLQLSQP QHDHETHSKA IQLNYFSFIA
Length:240
Mass (Da):27,428
Last modified:March 6, 2007 - v1
Checksum:i96DDECC135221A3B
GO
Isoform 2 (identifier: A2RVQ5-2) [UniParc]FASTAAdd to basket
Also known as: AGL16-II

The sequence of this isoform differs from the canonical sequence as follows:
     142-240: DQMLIEEIQV...IQLNYFSFIA → VLML

Show »
Length:145
Mass (Da):16,388
Checksum:i2B12ADE2FD115F62
GO

Sequence cautioni

The sequence CAB68129 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041688142 – 240DQMLI…FSFIA → VLML in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY141209 mRNA. Translation: AAN52773.1.
AL137080 Genomic DNA. Translation: CAB68129.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79629.1.
CP002686 Genomic DNA. Translation: AEE79630.2.
CP002686 Genomic DNA. Translation: ANM64245.1.
BT030046 mRNA. Translation: ABN04784.1.
AF312662 mRNA. Translation: AAG37899.1.
RefSeqiNP_001319775.1. NM_001339845.1. [A2RVQ5-2]
NP_001326287.1. NM_001339847.1. [A2RVQ5-1]
NP_191282.2. NM_115583.6. [A2RVQ5-1]
UniGeneiAt.21102.

Genome annotation databases

EnsemblPlantsiAT3G57230.1; AT3G57230.1; AT3G57230. [A2RVQ5-1]
AT3G57230.4; AT3G57230.4; AT3G57230. [A2RVQ5-1]
GeneIDi824890.
GrameneiAT3G57230.1; AT3G57230.1; AT3G57230.
AT3G57230.4; AT3G57230.4; AT3G57230.
KEGGiath:AT3G57230.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY141209 mRNA. Translation: AAN52773.1.
AL137080 Genomic DNA. Translation: CAB68129.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79629.1.
CP002686 Genomic DNA. Translation: AEE79630.2.
CP002686 Genomic DNA. Translation: ANM64245.1.
BT030046 mRNA. Translation: ABN04784.1.
AF312662 mRNA. Translation: AAG37899.1.
RefSeqiNP_001319775.1. NM_001339845.1. [A2RVQ5-2]
NP_001326287.1. NM_001339847.1. [A2RVQ5-1]
NP_191282.2. NM_115583.6. [A2RVQ5-1]
UniGeneiAt.21102.

3D structure databases

ProteinModelPortaliA2RVQ5.
SMRiA2RVQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10206. 23 interactors.
IntActiA2RVQ5. 19 interactors.
STRINGi3702.AT3G57230.1.

Proteomic databases

PaxDbiA2RVQ5.
PRIDEiA2RVQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G57230.1; AT3G57230.1; AT3G57230. [A2RVQ5-1]
AT3G57230.4; AT3G57230.4; AT3G57230. [A2RVQ5-1]
GeneIDi824890.
GrameneiAT3G57230.1; AT3G57230.1; AT3G57230.
AT3G57230.4; AT3G57230.4; AT3G57230.
KEGGiath:AT3G57230.

Organism-specific databases

AraportiAT3G57230.
TAIRilocus:2082618. AT3G57230.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiA2RVQ5.
OMAiASEIQFW.
OrthoDBiEOG09360MHP.
PhylomeDBiA2RVQ5.

Miscellaneous databases

PROiPR:A2RVQ5.

Gene expression databases

ExpressionAtlasiA2RVQ5. baseline and differential.
GenevisibleiA2RVQ5. AT.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiView protein in InterPro
IPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
PfamiView protein in Pfam
PF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
PRINTSiPR00404. MADSDOMAIN.
SMARTiView protein in SMART
SM00432. MADS. 1 hit.
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiView protein in PROSITE
PS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGL16_ARATH
AccessioniPrimary (citable) accession number: A2RVQ5
Secondary accession number(s): Q7XYY8, Q9FPP0, Q9M2M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 6, 2007
Last modified: May 10, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.