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A2RVP7

- TI221_ARATH

UniProt

A2RVP7 - TI221_ARATH

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Protein

Mitochondrial import inner membrane translocase subunit TIM22-1

Gene

TIM22-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.1 Publication

GO - Biological processi

  1. embryo development ending in seed dormancy Source: TAIR
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM22-1
Alternative name(s):
Protein MATERNAL EFFECT EMBRYO ARREST 67
Gene namesi
Name:TIM22-1
Synonyms:MEE67
Ordered Locus Names:At3g10110
ORF Names:T22K18.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G10110.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Embryo lethality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
BLAST
Chaini19 – 173155Mitochondrial import inner membrane translocase subunit TIM22-1PRO_0000420934Add
BLAST

Proteomic databases

PRIDEiA2RVP7.

Expressioni

Tissue specificityi

Expressed in young cotyledons, roots, flowers and leaves.2 Publications

Inductioni

Up-regulated after antimycin A or rotenone treatments.1 Publication

Gene expression databases

GenevestigatoriA2RVP7.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 11919HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14417HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 16818HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
InParanoidiA2RVP7.
KOiK17790.
OMAiGMESCVA.
PhylomeDBiA2RVP7.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RVP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSSAAEPT TGASSPPVAS DENSTQIQPI RMPTIEEIRA QEVWNNCAVR
60 70 80 90 100
AVTSGVMGGG LGLMMGLFLG ALDNPITHDT MTARQQFVFT AKQMGQRSWN
110 120 130 140 150
SCKTFAVMGL VFSAAECIVE KARAKHDTVN TAIAGCVTGG SMSARGGPKA
160 170
ACIGCAGFAT FSVLIEKFFD RHT
Length:173
Mass (Da):18,183
Last modified:March 6, 2007 - v1
Checksum:iCFC24979387481AB
GO

Sequence cautioni

The sequence AAF04413.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91P → T in ABD64057. (PubMed:17098851)Curated
Sequence conflicti9 – 91P → T in ABD64058. (PubMed:17098851)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ405268 mRNA. Translation: ABD64057.1.
DQ405269 mRNA. Translation: ABD64058.1.
AC010927 Genomic DNA. Translation: AAF04413.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE74859.1.
BT030038 mRNA. Translation: ABN04776.1.
RefSeqiNP_566368.1. NM_111846.3.
UniGeneiAt.39987.
At.41800.

Genome annotation databases

EnsemblPlantsiAT3G10110.1; AT3G10110.1; AT3G10110.
GeneIDi820172.
KEGGiath:AT3G10110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ405268 mRNA. Translation: ABD64057.1 .
DQ405269 mRNA. Translation: ABD64058.1 .
AC010927 Genomic DNA. Translation: AAF04413.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE74859.1 .
BT030038 mRNA. Translation: ABN04776.1 .
RefSeqi NP_566368.1. NM_111846.3.
UniGenei At.39987.
At.41800.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2RVP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G10110.1 ; AT3G10110.1 ; AT3G10110 .
GeneIDi 820172.
KEGGi ath:AT3G10110.

Organism-specific databases

GeneFarmi 3043. 302.
TAIRi AT3G10110.

Phylogenomic databases

eggNOGi COG5596.
InParanoidi A2RVP7.
KOi K17790.
OMAi GMESCVA.
PhylomeDBi A2RVP7.

Miscellaneous databases

PROi A2RVP7.

Gene expression databases

Genevestigatori A2RVP7.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the preprotein and amino acid transporter gene family in Arabidopsis."
    Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M., Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.
    Plant Physiol. 143:199-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis."
    Murcha M.W., Lister R., Ho A.Y., Whelan J.
    Plant Physiol. 131:1737-1747(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction."
    Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L., Millar A.H., Whelan J.
    Plant Physiol. 134:777-789(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  7. "Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis."
    Pagnussat G.C., Yu H.-J., Ngo Q.A., Rajani S., Mayalagu S., Johnson C.S., Capron A., Xie L.-F., Ye D., Sundaresan V.
    Development 132:603-614(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DISRUPTION PHENOTYPE.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTI221_ARATH
AccessioniPrimary (citable) accession number: A2RVP7
Secondary accession number(s): Q9SR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3