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A2RVP7

- TI221_ARATH

UniProt

A2RVP7 - TI221_ARATH

Protein

Mitochondrial import inner membrane translocase subunit TIM22-1

Gene

TIM22-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.1 Publication

    GO - Biological processi

    1. embryo development ending in seed dormancy Source: TAIR

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM22-1
    Alternative name(s):
    Protein MATERNAL EFFECT EMBRYO ARREST 67
    Gene namesi
    Name:TIM22-1
    Synonyms:MEE67
    Ordered Locus Names:At3g10110
    ORF Names:T22K18.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G10110.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Embryo lethality.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
    BLAST
    Chaini19 – 173155Mitochondrial import inner membrane translocase subunit TIM22-1PRO_0000420934Add
    BLAST

    Proteomic databases

    PRIDEiA2RVP7.

    Expressioni

    Tissue specificityi

    Expressed in young cotyledons, roots, flowers and leaves.2 Publications

    Inductioni

    Up-regulated after antimycin A or rotenone treatments.1 Publication

    Gene expression databases

    GenevestigatoriA2RVP7.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 11919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14417HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 16818HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    InParanoidiA2RVP7.
    KOiK17790.
    OMAiGMESCVA.
    PhylomeDBiA2RVP7.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2RVP7-1 [UniParc]FASTAAdd to Basket

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    MADSSAAEPT TGASSPPVAS DENSTQIQPI RMPTIEEIRA QEVWNNCAVR    50
    AVTSGVMGGG LGLMMGLFLG ALDNPITHDT MTARQQFVFT AKQMGQRSWN 100
    SCKTFAVMGL VFSAAECIVE KARAKHDTVN TAIAGCVTGG SMSARGGPKA 150
    ACIGCAGFAT FSVLIEKFFD RHT 173
    Length:173
    Mass (Da):18,183
    Last modified:March 6, 2007 - v1
    Checksum:iCFC24979387481AB
    GO

    Sequence cautioni

    The sequence AAF04413.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91P → T in ABD64057. (PubMed:17098851)Curated
    Sequence conflicti9 – 91P → T in ABD64058. (PubMed:17098851)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ405268 mRNA. Translation: ABD64057.1.
    DQ405269 mRNA. Translation: ABD64058.1.
    AC010927 Genomic DNA. Translation: AAF04413.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74859.1.
    BT030038 mRNA. Translation: ABN04776.1.
    RefSeqiNP_566368.1. NM_111846.3.
    UniGeneiAt.39987.
    At.41800.

    Genome annotation databases

    EnsemblPlantsiAT3G10110.1; AT3G10110.1; AT3G10110.
    GeneIDi820172.
    KEGGiath:AT3G10110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ405268 mRNA. Translation: ABD64057.1 .
    DQ405269 mRNA. Translation: ABD64058.1 .
    AC010927 Genomic DNA. Translation: AAF04413.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74859.1 .
    BT030038 mRNA. Translation: ABN04776.1 .
    RefSeqi NP_566368.1. NM_111846.3.
    UniGenei At.39987.
    At.41800.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2RVP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G10110.1 ; AT3G10110.1 ; AT3G10110 .
    GeneIDi 820172.
    KEGGi ath:AT3G10110.

    Organism-specific databases

    GeneFarmi 3043. 302.
    TAIRi AT3G10110.

    Phylogenomic databases

    eggNOGi COG5596.
    InParanoidi A2RVP7.
    KOi K17790.
    OMAi GMESCVA.
    PhylomeDBi A2RVP7.

    Miscellaneous databases

    PROi A2RVP7.

    Gene expression databases

    Genevestigatori A2RVP7.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the preprotein and amino acid transporter gene family in Arabidopsis."
      Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M., Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.
      Plant Physiol. 143:199-212(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis."
      Murcha M.W., Lister R., Ho A.Y., Whelan J.
      Plant Physiol. 131:1737-1747(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction."
      Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L., Millar A.H., Whelan J.
      Plant Physiol. 134:777-789(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    7. "Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis."
      Pagnussat G.C., Yu H.-J., Ngo Q.A., Rajani S., Mayalagu S., Johnson C.S., Capron A., Xie L.-F., Ye D., Sundaresan V.
      Development 132:603-614(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, DISRUPTION PHENOTYPE.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTI221_ARATH
    AccessioniPrimary (citable) accession number: A2RVP7
    Secondary accession number(s): Q9SR75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2013
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3