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Protein

Mitochondrial import inner membrane translocase subunit TIM22-1

Gene

TIM22-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • protein localization to organelle Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM22-1
Alternative name(s):
Protein MATERNAL EFFECT EMBRYO ARREST 67
Gene namesi
Name:TIM22-1
Synonyms:MEE67
Ordered Locus Names:At3g10110
ORF Names:T22K18.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G10110.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei101 – 119HelicalSequence analysisAdd BLAST19
Transmembranei128 – 144HelicalSequence analysisAdd BLAST17
Transmembranei151 – 168HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Embryo lethality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000042093419 – 173Mitochondrial import inner membrane translocase subunit TIM22-1Add BLAST155

Proteomic databases

PaxDbiA2RVP7.

Expressioni

Tissue specificityi

Expressed in young cotyledons, roots, flowers and leaves.2 Publications

Inductioni

Up-regulated after antimycin A or rotenone treatments.1 Publication

Gene expression databases

GenevisibleiA2RVP7. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G10110.1.

Structurei

3D structure databases

ProteinModelPortaliA2RVP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
InParanoidiA2RVP7.
KOiK17790.
OMAiMASNDNP.
OrthoDBiEOG09360R0A.
PhylomeDBiA2RVP7.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RVP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSAAEPT TGASSPPVAS DENSTQIQPI RMPTIEEIRA QEVWNNCAVR
60 70 80 90 100
AVTSGVMGGG LGLMMGLFLG ALDNPITHDT MTARQQFVFT AKQMGQRSWN
110 120 130 140 150
SCKTFAVMGL VFSAAECIVE KARAKHDTVN TAIAGCVTGG SMSARGGPKA
160 170
ACIGCAGFAT FSVLIEKFFD RHT
Length:173
Mass (Da):18,183
Last modified:March 6, 2007 - v1
Checksum:iCFC24979387481AB
GO

Sequence cautioni

The sequence AAF04413 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9P → T in ABD64057 (PubMed:17098851).Curated1
Sequence conflicti9P → T in ABD64058 (PubMed:17098851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ405268 mRNA. Translation: ABD64057.1.
DQ405269 mRNA. Translation: ABD64058.1.
AC010927 Genomic DNA. Translation: AAF04413.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE74859.1.
BT030038 mRNA. Translation: ABN04776.1.
RefSeqiNP_566368.1. NM_111846.3.
UniGeneiAt.39987.
At.41800.

Genome annotation databases

EnsemblPlantsiAT3G10110.1; AT3G10110.1; AT3G10110.
GeneIDi820172.
GrameneiAT3G10110.1; AT3G10110.1; AT3G10110.
KEGGiath:AT3G10110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ405268 mRNA. Translation: ABD64057.1.
DQ405269 mRNA. Translation: ABD64058.1.
AC010927 Genomic DNA. Translation: AAF04413.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE74859.1.
BT030038 mRNA. Translation: ABN04776.1.
RefSeqiNP_566368.1. NM_111846.3.
UniGeneiAt.39987.
At.41800.

3D structure databases

ProteinModelPortaliA2RVP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10110.1.

Proteomic databases

PaxDbiA2RVP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10110.1; AT3G10110.1; AT3G10110.
GeneIDi820172.
GrameneiAT3G10110.1; AT3G10110.1; AT3G10110.
KEGGiath:AT3G10110.

Organism-specific databases

TAIRiAT3G10110.

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
InParanoidiA2RVP7.
KOiK17790.
OMAiMASNDNP.
OrthoDBiEOG09360R0A.
PhylomeDBiA2RVP7.

Miscellaneous databases

PROiA2RVP7.

Gene expression databases

GenevisibleiA2RVP7. AT.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTI221_ARATH
AccessioniPrimary (citable) accession number: A2RVP7
Secondary accession number(s): Q9SR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.