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A2RUU4

- COLL1_HUMAN

UniProt

A2RUU4 - COLL1_HUMAN

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Protein

Colipase-like protein 1

Gene
CLPSL1, C6orf127
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro

GO - Biological processi

  1. digestion Source: InterPro
  2. lipid catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase-like protein 1
Gene namesi
Name:CLPSL1
Synonyms:C6orf127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21251. CLPSL1.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 12198Colipase-like protein 1PRO_0000337013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 50 By similarity
Disulfide bondi45 ↔ 61 By similarity
Disulfide bondi49 ↔ 83 By similarity
Disulfide bondi71 ↔ 91 By similarity
Disulfide bondi85 ↔ 107 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2RUU4.
PRIDEiA2RUU4.

PTM databases

PhosphoSiteiA2RUU4.

Expressioni

Tissue specificityi

Exclusively expressed in epididymis, in the corpus region.1 Publication

Gene expression databases

BgeeiA2RUU4.
CleanExiHS_C6orf127.
GenevestigatoriA2RUU4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362968.

Structurei

3D structure databases

ProteinModelPortaliA2RUU4.
SMRiA2RUU4. Positions 33-112.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113828.
HOGENOMiHOG000111566.
HOVERGENiHBG104657.
InParanoidiA2RUU4.
OMAiLRNLTCI.
OrthoDBiEOG74N5K5.
PhylomeDBiA2RUU4.
TreeFamiTF336178.

Family and domain databases

InterProiIPR001981. Colipase.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PRINTSiPR00128. COLIPASE.
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RUU4-1 [UniParc]FASTAAdd to Basket

« Hide

MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC    50
QRAPDNCESH CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL 100
SIAYGRCQKI GRQKLAKKMF F 121
Length:121
Mass (Da):14,057
Last modified:March 6, 2007 - v1
Checksum:iD73C9F747B130656
GO

Sequence cautioni

The sequence ABK41022.1 differs from that shown. Reason: Frameshift at position 120.
The sequence CAI21640.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151F → S.
Corresponds to variant rs34109614 [ dbSNP | Ensembl ].
VAR_043560

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921I → M in AAI50545. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ823638 mRNA. Translation: ABK41022.1. Frameshift.
AL157823 Genomic DNA. Translation: CAI21640.1. Sequence problems.
CH471081 Genomic DNA. Translation: EAX03849.1.
BC133046 mRNA. Translation: AAI33047.1.
BC137392 mRNA. Translation: AAI37393.1.
BC150543 mRNA. Translation: AAI50544.1.
BC150544 mRNA. Translation: AAI50545.1.
CCDSiCCDS43456.1.
RefSeqiNP_001010886.1. NM_001010886.3.
UniGeneiHs.131296.

Genome annotation databases

EnsembliENST00000373861; ENSP00000362968; ENSG00000204140.
GeneIDi340204.
KEGGihsa:340204.
UCSCiuc003old.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ823638 mRNA. Translation: ABK41022.1 . Frameshift.
AL157823 Genomic DNA. Translation: CAI21640.1 . Sequence problems.
CH471081 Genomic DNA. Translation: EAX03849.1 .
BC133046 mRNA. Translation: AAI33047.1 .
BC137392 mRNA. Translation: AAI37393.1 .
BC150543 mRNA. Translation: AAI50544.1 .
BC150544 mRNA. Translation: AAI50545.1 .
CCDSi CCDS43456.1.
RefSeqi NP_001010886.1. NM_001010886.3.
UniGenei Hs.131296.

3D structure databases

ProteinModelPortali A2RUU4.
SMRi A2RUU4. Positions 33-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362968.

PTM databases

PhosphoSitei A2RUU4.

Proteomic databases

PaxDbi A2RUU4.
PRIDEi A2RUU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373861 ; ENSP00000362968 ; ENSG00000204140 .
GeneIDi 340204.
KEGGi hsa:340204.
UCSCi uc003old.4. human.

Organism-specific databases

CTDi 340204.
GeneCardsi GC06P036314.
H-InvDB HIX0057777.
HGNCi HGNC:21251. CLPSL1.
neXtProti NX_A2RUU4.
PharmGKBi PA134984810.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG113828.
HOGENOMi HOG000111566.
HOVERGENi HBG104657.
InParanoidi A2RUU4.
OMAi LRNLTCI.
OrthoDBi EOG74N5K5.
PhylomeDBi A2RUU4.
TreeFami TF336178.

Miscellaneous databases

GenomeRNAii 340204.
NextBioi 97733.
PROi A2RUU4.

Gene expression databases

Bgeei A2RUU4.
CleanExi HS_C6orf127.
Genevestigatori A2RUU4.

Family and domain databases

InterProi IPR001981. Colipase.
[Graphical view ]
PANTHERi PTHR10041. PTHR10041. 1 hit.
PRINTSi PR00128. COLIPASE.
PROSITEi PS51342. COLIPASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptome analysis of a cDNA library from adult human epididymis."
    Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
    DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Tissue: Epididymis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCOLL1_HUMAN
AccessioniPrimary (citable) accession number: A2RUU4
Secondary accession number(s): A7E2T6
, B2RPE2, B5G4V2, B6ZDM9, Q5T9G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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