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A2RUU4

- COLL1_HUMAN

UniProt

A2RUU4 - COLL1_HUMAN

Protein

Colipase-like protein 1

Gene

CLPSL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro

    GO - Biological processi

    1. digestion Source: InterPro
    2. lipid catabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Colipase-like protein 1
    Gene namesi
    Name:CLPSL1
    Synonyms:C6orf127
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21251. CLPSL1.

    Subcellular locationi

    Secreted PROSITE-ProRule annotation

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12198Colipase-like protein 1PRO_0000337013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 50PROSITE-ProRule annotation
    Disulfide bondi45 ↔ 61PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 83PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 91PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 107PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiA2RUU4.
    PRIDEiA2RUU4.

    PTM databases

    PhosphoSiteiA2RUU4.

    Expressioni

    Tissue specificityi

    Exclusively expressed in epididymis, in the corpus region.1 Publication

    Gene expression databases

    BgeeiA2RUU4.
    CleanExiHS_C6orf127.
    GenevestigatoriA2RUU4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362968.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RUU4.
    SMRiA2RUU4. Positions 33-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the colipase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113828.
    HOGENOMiHOG000111566.
    HOVERGENiHBG104657.
    InParanoidiA2RUU4.
    OMAiLRNLTCI.
    OrthoDBiEOG74N5K5.
    PhylomeDBiA2RUU4.
    TreeFamiTF336178.

    Family and domain databases

    InterProiIPR001981. Colipase.
    [Graphical view]
    PANTHERiPTHR10041. PTHR10041. 1 hit.
    PRINTSiPR00128. COLIPASE.
    PROSITEiPS51342. COLIPASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2RUU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC    50
    QRAPDNCESH CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL 100
    SIAYGRCQKI GRQKLAKKMF F 121
    Length:121
    Mass (Da):14,057
    Last modified:March 6, 2007 - v1
    Checksum:iD73C9F747B130656
    GO

    Sequence cautioni

    The sequence ABK41022.1 differs from that shown. Reason: Frameshift at position 120.
    The sequence CAI21640.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921I → M in AAI50545. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151F → S.
    Corresponds to variant rs34109614 [ dbSNP | Ensembl ].
    VAR_043560

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ823638 mRNA. Translation: ABK41022.1. Frameshift.
    AL157823 Genomic DNA. Translation: CAI21640.1. Sequence problems.
    CH471081 Genomic DNA. Translation: EAX03849.1.
    BC133046 mRNA. Translation: AAI33047.1.
    BC137392 mRNA. Translation: AAI37393.1.
    BC150543 mRNA. Translation: AAI50544.1.
    BC150544 mRNA. Translation: AAI50545.1.
    CCDSiCCDS43456.1.
    RefSeqiNP_001010886.1. NM_001010886.3.
    UniGeneiHs.131296.

    Genome annotation databases

    EnsembliENST00000373861; ENSP00000362968; ENSG00000204140.
    GeneIDi340204.
    KEGGihsa:340204.
    UCSCiuc003old.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ823638 mRNA. Translation: ABK41022.1 . Frameshift.
    AL157823 Genomic DNA. Translation: CAI21640.1 . Sequence problems.
    CH471081 Genomic DNA. Translation: EAX03849.1 .
    BC133046 mRNA. Translation: AAI33047.1 .
    BC137392 mRNA. Translation: AAI37393.1 .
    BC150543 mRNA. Translation: AAI50544.1 .
    BC150544 mRNA. Translation: AAI50545.1 .
    CCDSi CCDS43456.1.
    RefSeqi NP_001010886.1. NM_001010886.3.
    UniGenei Hs.131296.

    3D structure databases

    ProteinModelPortali A2RUU4.
    SMRi A2RUU4. Positions 33-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362968.

    PTM databases

    PhosphoSitei A2RUU4.

    Proteomic databases

    PaxDbi A2RUU4.
    PRIDEi A2RUU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373861 ; ENSP00000362968 ; ENSG00000204140 .
    GeneIDi 340204.
    KEGGi hsa:340204.
    UCSCi uc003old.4. human.

    Organism-specific databases

    CTDi 340204.
    GeneCardsi GC06P036314.
    H-InvDB HIX0057777.
    HGNCi HGNC:21251. CLPSL1.
    neXtProti NX_A2RUU4.
    PharmGKBi PA134984810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG113828.
    HOGENOMi HOG000111566.
    HOVERGENi HBG104657.
    InParanoidi A2RUU4.
    OMAi LRNLTCI.
    OrthoDBi EOG74N5K5.
    PhylomeDBi A2RUU4.
    TreeFami TF336178.

    Miscellaneous databases

    GenomeRNAii 340204.
    NextBioi 97733.
    PROi A2RUU4.

    Gene expression databases

    Bgeei A2RUU4.
    CleanExi HS_C6orf127.
    Genevestigatori A2RUU4.

    Family and domain databases

    InterProi IPR001981. Colipase.
    [Graphical view ]
    PANTHERi PTHR10041. PTHR10041. 1 hit.
    PRINTSi PR00128. COLIPASE.
    PROSITEi PS51342. COLIPASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptome analysis of a cDNA library from adult human epididymis."
      Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
      DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
      Tissue: Epididymis.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCOLL1_HUMAN
    AccessioniPrimary (citable) accession number: A2RUU4
    Secondary accession number(s): A7E2T6
    , B2RPE2, B5G4V2, B6ZDM9, Q5T9G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3