A2RUU4 (COLL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Colipase-like protein 1

Gene names

Name:	CLPSL1
Synonyms:	C6orf127

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Exclusively expressed in epididymis, in the corpus region. Ref.1
Sequence similarities	Belongs to the colipase family.
Sequence caution	The sequence ABK41022.1 differs from that shown. Reason: Frameshift at position 120. The sequence CAI21640.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	digestion Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: InterPro positive regulation of catalytic activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	enzyme activator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 121	98	Colipase-like protein 1		PRO_0000337013
Amino acid modifications
	Disulfide bond	39 ↔ 50		By similarity
	Disulfide bond	45 ↔ 61		By similarity
	Disulfide bond	49 ↔ 83		By similarity
	Disulfide bond	71 ↔ 91		By similarity
	Disulfide bond	85 ↔ 107		By similarity
Natural variations
	Natural variant	15	1	F → S. Corresponds to variant rs34109614 [ dbSNP | Ensembl ].		VAR_043560
Experimental info
	Sequence conflict	92	1	I → M in AAI50545. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	A2RUU4 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: D73C9F747B130656	FASTA	121	14,057
	10 20 30 40 50 60 MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC QRAPDNCESH 70 80 90 100 110 120 CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL SIAYGRCQKI GRQKLAKKMF F

References

[1]	"Transcriptome analysis of a cDNA library from adult human epididymis." Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L. DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY. Tissue: Epididymis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ823638 mRNA. Translation: ABK41022.1. Frameshift. AL157823 Genomic DNA. Translation: CAI21640.1. Sequence problems. CH471081 Genomic DNA. Translation: EAX03849.1. BC133046 mRNA. Translation: AAI33047.1. BC137392 mRNA. Translation: AAI37393.1. BC150543 mRNA. Translation: AAI50544.1. BC150544 mRNA. Translation: AAI50545.1.
IPI	IPI00796447.
RefSeq	NP_001010886.1. NM_001010886.3.
UniGene	Hs.131296.
3D structure databases
ProteinModelPortal	A2RUU4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000362968.
PTM databases
PhosphoSite	A2RUU4.
Proteomic databases
PaxDb	A2RUU4.
PRIDE	A2RUU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373861; ENSP00000362968; ENSG00000204140.
GeneID	340204.
KEGG	hsa:340204.
UCSC	uc003old.4. human.
Organism-specific databases
CTD	340204.
GeneCards	GC06P035749.
H-InvDB	HIX0057777.
HGNC	HGNC:21251. CLPSL1.
neXtProt	NX_A2RUU4.
PharmGKB	PA134984810.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG113828.
HOGENOM	HOG000111566.
HOVERGEN	HBG104657.
InParanoid	A2RUU4.
OrthoDB	EOG498V28.
Gene expression databases
ArrayExpress	A2RUU4.
Bgee	A2RUU4.
CleanEx	HS_C6orf127.
Genevestigator	A2RUU4.
Family and domain databases
InterPro	IPR001981. Colipase. [Graphical view]
PANTHER	PTHR10041. PTHR10041. 1 hit.
PRINTS	PR00128. COLIPASE.
PROSITE	PS00121. COLIPASE_1. False negative. PS51342. COLIPASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340204.
NextBio	97733.

Entry information

Entry name

COLL1_HUMAN

Accession

Primary (citable) accession number: A2RUU4
Secondary accession number(s): A7E2T6 , B2RPE2, B5G4V2, B6ZDM9, Q5T9G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.