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Protein

Colipase-like protein 1

Gene

CLPSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro

GO - Biological processi

  1. digestion Source: InterPro
  2. lipid catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase-like protein 1
Gene namesi
Name:CLPSL1
Synonyms:C6orf127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21251. CLPSL1.

Subcellular locationi

  1. Secreted PROSITE-ProRule annotation

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984810.

Polymorphism and mutation databases

BioMutaiCLPSL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12198Colipase-like protein 1PRO_0000337013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 50PROSITE-ProRule annotation
Disulfide bondi45 ↔ 61PROSITE-ProRule annotation
Disulfide bondi49 ↔ 83PROSITE-ProRule annotation
Disulfide bondi71 ↔ 91PROSITE-ProRule annotation
Disulfide bondi85 ↔ 107PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2RUU4.
PRIDEiA2RUU4.

PTM databases

PhosphoSiteiA2RUU4.

Expressioni

Tissue specificityi

Exclusively expressed in epididymis, in the corpus region.1 Publication

Gene expression databases

BgeeiA2RUU4.
CleanExiHS_C6orf127.
ExpressionAtlasiA2RUU4. baseline.
GenevestigatoriA2RUU4.

Interactioni

Protein-protein interaction databases

BioGridi131012. 6 interactions.
STRINGi9606.ENSP00000362968.

Structurei

3D structure databases

ProteinModelPortaliA2RUU4.
SMRiA2RUU4. Positions 33-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113828.
GeneTreeiENSGT00510000049845.
HOGENOMiHOG000111566.
HOVERGENiHBG104657.
InParanoidiA2RUU4.
OMAiSPTKYNL.
OrthoDBiEOG74N5K5.
PhylomeDBiA2RUU4.
TreeFamiTF336178.

Family and domain databases

InterProiIPR001981. Colipase.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PRINTSiPR00128. COLIPASE.
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RUU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC
60 70 80 90 100
QRAPDNCESH CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL
110 120
SIAYGRCQKI GRQKLAKKMF F
Length:121
Mass (Da):14,057
Last modified:March 6, 2007 - v1
Checksum:iD73C9F747B130656
GO

Sequence cautioni

The sequence ABK41022.1 differs from that shown. Reason: Frameshift at position 120. Curated
The sequence CAI21640.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921I → M in AAI50545 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151F → S.
Corresponds to variant rs34109614 [ dbSNP | Ensembl ].
VAR_043560

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823638 mRNA. Translation: ABK41022.1. Frameshift.
AL157823 Genomic DNA. Translation: CAI21640.1. Sequence problems.
CH471081 Genomic DNA. Translation: EAX03849.1.
BC133046 mRNA. Translation: AAI33047.1.
BC137392 mRNA. Translation: AAI37393.1.
BC150543 mRNA. Translation: AAI50544.1.
BC150544 mRNA. Translation: AAI50545.1.
CCDSiCCDS43456.1.
RefSeqiNP_001010886.1. NM_001010886.3.
UniGeneiHs.131296.

Genome annotation databases

EnsembliENST00000373861; ENSP00000362968; ENSG00000204140.
GeneIDi340204.
KEGGihsa:340204.
UCSCiuc003old.4. human.

Polymorphism and mutation databases

BioMutaiCLPSL1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823638 mRNA. Translation: ABK41022.1. Frameshift.
AL157823 Genomic DNA. Translation: CAI21640.1. Sequence problems.
CH471081 Genomic DNA. Translation: EAX03849.1.
BC133046 mRNA. Translation: AAI33047.1.
BC137392 mRNA. Translation: AAI37393.1.
BC150543 mRNA. Translation: AAI50544.1.
BC150544 mRNA. Translation: AAI50545.1.
CCDSiCCDS43456.1.
RefSeqiNP_001010886.1. NM_001010886.3.
UniGeneiHs.131296.

3D structure databases

ProteinModelPortaliA2RUU4.
SMRiA2RUU4. Positions 33-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131012. 6 interactions.
STRINGi9606.ENSP00000362968.

PTM databases

PhosphoSiteiA2RUU4.

Polymorphism and mutation databases

BioMutaiCLPSL1.

Proteomic databases

PaxDbiA2RUU4.
PRIDEiA2RUU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373861; ENSP00000362968; ENSG00000204140.
GeneIDi340204.
KEGGihsa:340204.
UCSCiuc003old.4. human.

Organism-specific databases

CTDi340204.
GeneCardsiGC06P037301.
H-InvDBHIX0057777.
HGNCiHGNC:21251. CLPSL1.
neXtProtiNX_A2RUU4.
PharmGKBiPA134984810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG113828.
GeneTreeiENSGT00510000049845.
HOGENOMiHOG000111566.
HOVERGENiHBG104657.
InParanoidiA2RUU4.
OMAiSPTKYNL.
OrthoDBiEOG74N5K5.
PhylomeDBiA2RUU4.
TreeFamiTF336178.

Miscellaneous databases

GenomeRNAii340204.
NextBioi97733.
PROiA2RUU4.

Gene expression databases

BgeeiA2RUU4.
CleanExiHS_C6orf127.
ExpressionAtlasiA2RUU4. baseline.
GenevestigatoriA2RUU4.

Family and domain databases

InterProiIPR001981. Colipase.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PRINTSiPR00128. COLIPASE.
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Transcriptome analysis of a cDNA library from adult human epididymis."
    Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
    DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Tissue: Epididymis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCOLL1_HUMAN
AccessioniPrimary (citable) accession number: A2RUU4
Secondary accession number(s): A7E2T6
, B2RPE2, B5G4V2, B6ZDM9, Q5T9G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: April 29, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.