Unreviewed, UniProtKB/TrEMBL A2RUN4 (A2RUN4_HUMAN)

Names and origin

Protein names

Recommended name:
    Transporter RuleBase RU003732V4

Gene names

Name:	SLC6A3 EMBL AAI32978.1
ORF Names:	hCG_19522 EMBL EAX08159.1

Organism

Homo sapiens (Human) EMBL AAI32978.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) family. RuleBase RU003732V4

Ontologies

Keywords
Biological process	Symport RuleBase RU003732V4 Spearmint SPM000175 Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003732V4 Spearmint SPM000175
Gene Ontology (GO)
Biological process	adenohypophysis development Inferred from electronic annotation. Source: Compara dopamine biosynthetic process Inferred from electronic annotation. Source: Compara dopamine catabolic process Inferred from electronic annotation. Source: Compara dopamine transport Inferred from electronic annotation. Source: Compara lactation Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara neurotransmitter transport Inferred from electronic annotation. Source: InterPro positive regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara prepulse inhibition Inferred from electronic annotation. Source: Compara regulation of dopamine metabolic process Inferred from electronic annotation. Source: Compara sensory perception of smell Inferred from electronic annotation. Source: Compara
Cellular component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular function	dopamine:sodium symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2RUN4-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: CD95009B6BA93108	FASTA	620	68,495
	10 20 30 40 50 60 MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR 70 80 90 100 110 120 ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 130 140 150 160 170 180 GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC 190 200 210 220 230 240 NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL 250 260 270 280 290 300 TACLVLVIVL LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV 310 320 330 340 350 360 DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS 370 380 390 400 410 420 GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAVV FFIMLLTLGI 430 440 450 460 470 480 DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA 490 500 510 520 530 540 GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI 550 560 570 580 590 600 VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 610 620 RELVDRGEVR QFTLRHWLKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pooled EMBL AAI32978.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Sequence variation in the primate dopamine transporter gene and its relationship to social dominance." Miller-Butterworth C.M., Kaplan J.R., Shaffer J., Devlin B., Manuck S.B., Ferrell R.E. Mol. Biol. Evol. 25:18-28(2008) [PubMed: 17934207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC132977 mRNA. Translation: AAI32978.1. BC133003 mRNA. Translation: AAI33004.1. EF174603 mRNA. Translation: ABO77644.1. CH471102 Genomic DNA. Translation: EAX08159.1.
IPI	IPI00219765.
RefSeq	NP_001035.1.
UniGene	Hs.406
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A2RUN4.
Genome annotation databases
Ensembl	ENSG00000142319. Homo sapiens. [Contig view]
GeneID	6531.
KEGG	hsa:6531.
Organism-specific databases
HGNC	HGNC:11049. SLC6A3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	A2RUN4.
OMA	A2RUN4. AWFYGVG.
Gene expression databases
Bgee	A2RUN4.
Family and domain databases
InterPro	IPR000175. Na/ntran_symport. IPR002436. Na/ntran_symport_dopamine. [Graphical view]
PANTHER	PTHR11616. Na/ntran_symport. 1 hit.
Pfam	PF00209. SNF. 1 hit. [Graphical view]
PRINTS	PR01202. DOPTRANSPORT. PR00176. NANEUSMPORT.
ProDom	PD000448. Na/ntran_symport. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00610. NA_NEUROTRAN_SYMP_1. 1 hit. PS00754. NA_NEUROTRAN_SYMP_2. 1 hit. PS50267. NA_NEUROTRAN_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25411.

Entry information

Entry name

A2RUN4_HUMAN

Accession

Primary (citable) accession number: A2RUN4

Entry history

Integrated into UniProtKB/TrEMBL:	March 6, 2007
Last sequence update:	March 6, 2007
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)