A2RUF7 (A2RUF7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphoinositide-3-kinase, class 2, beta polypeptide EMBL AAI32877.1

Submitted name:
Phosphoinositide-3-kinase, class 2, beta polypeptide, isoform CRA_b EMBL EAW91514.1

Gene names

Name:	PIK3C2B EMBL AAI32877.1
ORF Names:	hCG_16410 EMBL EAW91514.1

Organism

Homo sapiens (Human) EMBL AAI32877.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1634 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412 Contains 1 PI3K/PI4K domain. SAAS SAAS018936 Contains 1 PIK helical domain. SAAS SAAS015433

Ontologies

Keywords
Molecular function	Kinase SAAS SAAS018936 EMBL AAI32877.1 Transferase
Gene Ontology (GO)
Biological process	phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular component	phosphatidylinositol 3-kinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: InterPro phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2RUF7 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: CA817BA77C12E833	FASTA	1,634	184,768
	10 20 30 40 50 60 MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK QNADPSLISW 70 80 90 100 110 120 DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE GPPNHSTSQG PQPGSDPWPK 130 140 150 160 170 180 GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS CKKLSPPPLP PRASIWDTPP LPPRKGSPSS 190 200 210 220 230 240 SKISQPSDIN TFSLVEQLPG KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL 250 260 270 280 290 300 KSTYDAEMLR DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT 310 320 330 340 350 360 PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS DIQDYFLTGY 370 380 390 400 410 420 VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST VDLLIYQTLC YTHDDLRNVD 430 440 450 460 470 480 VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS 490 500 510 520 530 540 PSTLNYLVHL QERPVKQTIS RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC 550 560 570 580 590 600 NALAAVETPE ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY 610 620 630 640 650 660 CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE DFYLSCSLSH 670 680 690 700 710 720 GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP RETLLCATLY ALPIPPPGSS 730 740 750 760 770 780 SEANKQRRVP EALGWVTTPL FNFRQVLTCG RKLLGLWPAT QENPSARWSA PNFHQPDSVI 790 800 810 820 830 840 LQIDFPTSAF DIKFTSPPGD KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW 850 860 870 880 890 900 EKRYYCHSEV SSLPLVLASA PSWEWACLPD IYVLLKQWTH MNHQDALGLL HATFPDQEVR 910 920 930 940 950 960 RMAVQWIGSL SDAELLDYLP QLVQALKYEC YLDSPLVRFL LKRAVSDLRV THYFFWLLKD 970 980 990 1000 1010 1020 GLKDSQFSIR YQYLLAALLC CCGKGLREEF NRQCWLVNAL AKLAQQVREA APSARQGILR 1030 1040 1050 1060 1070 1080 TGLEEVKQFF ALNGSCRLPL SPSLLVKGIV PRDCSYFNSN AVPLKLSFQN VDPLGENIRV 1090 1100 1110 1120 1130 1140 IFKCGDDLRQ DMLTLQMIRI MSKIWVQEGL DMRMVIFRCF STGRGRGMVE MIPNAETLRK 1150 1160 1170 1180 1190 1200 IQVEHGVTGS FKDRPLADWL QKHNPGEDEY EKAVENFIYS CAGCCVATYV LGICDRHNDN 1210 1220 1230 1240 1250 1260 IMLKTTGHMF HIDFGRFLGH AQMFGNIKRD RAPFVFTSDM AYVINGGDKP SSRFHDFVDL 1270 1280 1290 1300 1310 1320 CCQAYNLIRK HTHLFLNLLG LMLSCGIPEL SDLEDLKYVY DALRPQDTEA NATTYFTRLI 1330 1340 1350 1360 1370 1380 ESSLGSVATK LNFFIHNLAQ MKFTGSDDRL TLSFASRTHT LKSSGRISDV FLCRHEKIFH 1390 1400 1410 1420 1430 1440 PNKGYIYVVK VMRENTHEAT YIQRTFEEFQ ELHNKLRLLF PSSHLPSFPS RFVIGRSRGE 1450 1460 1470 1480 1490 1500 AVAERRREEL NGYIWHLIHA PPEVAECDLV YTFFHPLPRD EKAMGTSPAP KSSDGTWARP 1510 1520 1530 1540 1550 1560 VGKVGGEVKL SISYKNNKLF IMVMHIRGLQ LLQDGNDPDP YVKIYLLPDP QKTTKRKTKV 1570 1580 1590 1600 1610 1620 ARKTCNPTYN EMLVYDGIPK GDLQQRELQL SVLSEQGFWE NVLLGEVNIR LRELDLAQEK 1630 TGWFALGSRS HGTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pooled EMBL AAI32877.1 and Testicle EMBL AAI36646.1.
[2]	Livingston R.J., Rieder M.J., McFarland I.W., da Ponte S.H., Aklestad J., Swanson J., Johnson E., Nickerson D.A. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC132876 mRNA. Translation: AAI32877.1. BC136645 mRNA. Translation: AAI36646.1. EU332863 Genomic DNA. Translation: ABY87552.1. CH471067 Genomic DNA. Translation: EAW91514.1.
IPI	IPI00292056.
RefSeq	NP_002637.3. NM_002646.3.
UniGene	Hs.497487.
3D structure databases
ProteinModelPortal	A2RUF7.
SMR	A2RUF7. Positions 322-1341, 1352-1482, 1505-1628.
ModBase	Search...
Protein-protein interaction databases
STRING	A2RUF7.
Proteomic databases
PRIDE	A2RUF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5287.
KEGG	hsa:5287.
UCSC	uc001haw.1. human.
Organism-specific databases
CTD	5287.
PharmGKB	PA33305.
Phylogenomic databases
eggNOG	prNOG05802.
HOVERGEN	HBG082099.
OMA	KESLYWL.
PhylomeDB	A2RUF7.
Gene expression databases
Bgee	A2RUF7.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011009. Kinase-like_dom. IPR001683. Phox. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2. IPR000341. PI3K_ras-bd. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit. G3DSA:3.30.1520.10. PX. 1 hit.
KO	K00923.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00168. C2. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. PF00787. PX. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00142. PI3K_C2. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 2 hits. SSF56112. Kinase_like. 1 hit. SSF64268. PX. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A2RUF7_HUMAN

Accession

Primary (citable) accession number: A2RUF7

Entry history

Integrated into UniProtKB/TrEMBL:	March 6, 2007
Last sequence update:	March 6, 2007
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.