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Protein

Coiled-coil domain-containing protein 66

Gene

CCDC66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 66
Gene namesi
Name:CCDC66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27709. CCDC66.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485418.

Polymorphism and mutation databases

BioMutaiCCDC66.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Coiled-coil domain-containing protein 66PRO_0000320037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphothreonineCombined sources
Modified residuei121 – 1211PhosphothreonineCombined sources
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei606 – 6061PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2RUB6.
MaxQBiA2RUB6.
PaxDbiA2RUB6.
PeptideAtlasiA2RUB6.
PRIDEiA2RUB6.
TopDownProteomicsiA2RUB6-4. [A2RUB6-4]

PTM databases

iPTMnetiA2RUB6.
PhosphoSiteiA2RUB6.

Expressioni

Gene expression databases

BgeeiA2RUB6.
CleanExiHS_CCDC66.
ExpressionAtlasiA2RUB6. baseline and differential.
GenevisibleiA2RUB6. HS.

Organism-specific databases

HPAiHPA044185.

Interactioni

Protein-protein interaction databases

BioGridi130082. 14 interactions.
IntActiA2RUB6. 16 interactions.
MINTiMINT-7034509.
STRINGi9606.ENSP00000378167.

Structurei

3D structure databases

ProteinModelPortaliA2RUB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili252 – 28332Sequence analysisAdd
BLAST
Coiled coili466 – 569104Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGGF. Eukaryota.
ENOG4111QS7. LUCA.
GeneTreeiENSGT00390000012411.
HOGENOMiHOG000111429.
HOVERGENiHBG107617.
InParanoidiA2RUB6.
OMAiEWKPADI.
PhylomeDBiA2RUB6.
TreeFamiTF350489.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RUB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLGDGLKLE TELLDGKTKL ILSPYEHKSK ISVKMGNKAK IAKCPLRTKT
60 70 80 90 100
GHILKSTQDT CIGSEKLLQK KPVGSETSQA KGEKNGMTFS STKDLCKQCI
110 120 130 140 150
DKDCLHIQKE ISPATPNMQK TRNTVNTSLV GKQKPHKKHI TAENMKSSLV
160 170 180 190 200
CLTQDQLQQI LMTVNQGNRS LSLTENGKEA KSQYSLYLNS ISNQPKDENI
210 220 230 240 250
MGLFKKTEMV SSVPAENKSV LNEHQETSKQ CEQKIAIENE WKPADIFSTL
260 270 280 290 300
GERECDRSSL EAKKAQWRKE LDEQVALKKK EKEVSEKWND PWKKSESDKI
310 320 330 340 350
IWEKHQILDQ SRETVLLEHP FSAVKQELQR KWIEELNKQI EDDRQRKIEE
360 370 380 390 400
KIIYSKGEEH DRWAMHFDSL KSYPGSQSQL FSQSTHKQPE YFCVSPDTQE
410 420 430 440 450
LADVSSVCTP TTGSQVEPSE EEHIAKPIKD VVMANSKKTN FLRSMTALLD
460 470 480 490 500
PAQIEERDRR RQKQLEHQKA ITAQVEEKRR KKQLEEEQRK KEEQEEELRL
510 520 530 540 550
AQEREEMQKQ YEEDILKQKQ KEEIMTLKTN ELFQTMQRAQ ELAQRLKQEQ
560 570 580 590 600
RIRELAQKGH DTSRLIKNLG VDTIQMEYNA SNISNSRHDS DEISGKMNTY
610 620 630 640 650
MNSTTSKKDT GVQTDDLNIG IFTNAESHCG SLMERDITNC SSPEISAELI
660 670 680 690 700
GQFSTKKNKQ ELTQDKGASL EKENNRCNDQ CNQFTRIEKQ TKHMKKYPKR
710 720 730 740 750
PDWNINKPPK RYIPASEKYP KQLQKQREEK KVRRQMELLH LVEKNNPGHL
760 770 780 790 800
SQNRGISPEI FHSSHQETES KLRWHLVKKE EEPLNIHSFS KERSPSSPVP
810 820 830 840 850
VVKNRTQQTQ NTLHLPLKNS SYERENLISG SNQTELSSGI SESSHFIPYV
860 870 880 890 900
RTNEIYYLDP DAPLSGPSTQ DPQYQNSQDC GQKRQLFDSD CVRDPLLNPN
910 920 930 940
MVKNRDRQQA ILKGLSELRQ GLLQKQKELE SSLLPLAENQ EESFGSSF
Length:948
Mass (Da):109,411
Last modified:March 3, 2009 - v4
Checksum:i2F7516E4C32C0310
GO
Isoform 2 (identifier: A2RUB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-287: DEQVALKKKEKEVSEK → VLQTVQAWYQHLLGFW
     288-948: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):32,307
Checksum:iAD9045604723611A
GO
Isoform 3 (identifier: A2RUB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:914
Mass (Da):105,630
Checksum:i11E3CAF37D3F2AF6
GO
Isoform 4 (identifier: A2RUB6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     231-948: Missing.

Show »
Length:196
Mass (Da):21,735
Checksum:i556250D8CECAF6C8
GO

Sequence cautioni

The sequence AAH47509.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI32828.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04607.1 differs from that shown. Reason: Frameshift at position 214. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041C → Y in BAC04607 (PubMed:14702039).Curated
Sequence conflicti605 – 6051T → TS in AAI32828 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti383 – 3831Q → R.1 Publication
Corresponds to variant rs1491170 [ dbSNP | Ensembl ].
VAR_039111
Natural varianti460 – 4601R → Q.1 Publication
Corresponds to variant rs7637449 [ dbSNP | Ensembl ].
VAR_039112
Natural varianti592 – 5921E → K.
Corresponds to variant rs4681904 [ dbSNP | Ensembl ].
VAR_039113

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 3 and isoform 4. 2 PublicationsVSP_036545Add
BLAST
Alternative sequencei231 – 948718Missing in isoform 4. 1 PublicationVSP_036546Add
BLAST
Alternative sequencei272 – 28716DEQVA…EVSEK → VLQTVQAWYQHLLGFW in isoform 2. 1 PublicationVSP_031586Add
BLAST
Alternative sequencei288 – 948661Missing in isoform 2. 1 PublicationVSP_031587Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095688 mRNA. Translation: BAC04607.1. Frameshift.
AK125303 mRNA. Translation: BAG54180.1.
AC098478 Genomic DNA. No translation available.
AC099781 Genomic DNA. No translation available.
BC047509 mRNA. Translation: AAH47509.1. Different initiation.
BC132827 mRNA. Translation: AAI32828.2. Different initiation.
CCDSiCCDS33770.2. [A2RUB6-3]
CCDS46852.1. [A2RUB6-1]
RefSeqiNP_001012524.4. NM_001012506.4. [A2RUB6-3]
NP_001135419.1. NM_001141947.1. [A2RUB6-1]
UniGeneiHs.476399.

Genome annotation databases

EnsembliENST00000326595; ENSP00000326050; ENSG00000180376. [A2RUB6-3]
ENST00000394672; ENSP00000378167; ENSG00000180376. [A2RUB6-1]
GeneIDi285331.
KEGGihsa:285331.
UCSCiuc003dhu.4. human. [A2RUB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095688 mRNA. Translation: BAC04607.1. Frameshift.
AK125303 mRNA. Translation: BAG54180.1.
AC098478 Genomic DNA. No translation available.
AC099781 Genomic DNA. No translation available.
BC047509 mRNA. Translation: AAH47509.1. Different initiation.
BC132827 mRNA. Translation: AAI32828.2. Different initiation.
CCDSiCCDS33770.2. [A2RUB6-3]
CCDS46852.1. [A2RUB6-1]
RefSeqiNP_001012524.4. NM_001012506.4. [A2RUB6-3]
NP_001135419.1. NM_001141947.1. [A2RUB6-1]
UniGeneiHs.476399.

3D structure databases

ProteinModelPortaliA2RUB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130082. 14 interactions.
IntActiA2RUB6. 16 interactions.
MINTiMINT-7034509.
STRINGi9606.ENSP00000378167.

PTM databases

iPTMnetiA2RUB6.
PhosphoSiteiA2RUB6.

Polymorphism and mutation databases

BioMutaiCCDC66.

Proteomic databases

EPDiA2RUB6.
MaxQBiA2RUB6.
PaxDbiA2RUB6.
PeptideAtlasiA2RUB6.
PRIDEiA2RUB6.
TopDownProteomicsiA2RUB6-4. [A2RUB6-4]

Protocols and materials databases

DNASUi285331.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326595; ENSP00000326050; ENSG00000180376. [A2RUB6-3]
ENST00000394672; ENSP00000378167; ENSG00000180376. [A2RUB6-1]
GeneIDi285331.
KEGGihsa:285331.
UCSCiuc003dhu.4. human. [A2RUB6-1]

Organism-specific databases

CTDi285331.
GeneCardsiCCDC66.
HGNCiHGNC:27709. CCDC66.
HPAiHPA044185.
neXtProtiNX_A2RUB6.
PharmGKBiPA143485418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGF. Eukaryota.
ENOG4111QS7. LUCA.
GeneTreeiENSGT00390000012411.
HOGENOMiHOG000111429.
HOVERGENiHBG107617.
InParanoidiA2RUB6.
OMAiEWKPADI.
PhylomeDBiA2RUB6.
TreeFamiTF350489.

Miscellaneous databases

ChiTaRSiCCDC66. human.
GenomeRNAii285331.
PROiA2RUB6.

Gene expression databases

BgeeiA2RUB6.
CleanExiHS_CCDC66.
ExpressionAtlasiA2RUB6. baseline and differential.
GenevisibleiA2RUB6. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain and Teratocarcinoma.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS ARG-383 AND GLN-460.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-115 AND THR-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCCD66_HUMAN
AccessioniPrimary (citable) accession number: A2RUB6
Secondary accession number(s): B3KWL8, Q4VC34, Q8N949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 3, 2009
Last modified: July 6, 2016
This is version 76 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.