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Protein

Uncharacterized protein KIAA1467

Gene

KIAA1467

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1467
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29288. KIAA1467.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Uncharacterized protein KIAA1467PRO_0000288913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine2 Publications
Modified residuei26 – 261Phosphothreonine1 Publication
Modified residuei30 – 301Phosphoserine2 Publications
Modified residuei33 – 331Phosphoserine2 Publications
Modified residuei62 – 621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2RU67.
PaxDbiA2RU67.
PRIDEiA2RU67.

PTM databases

PhosphoSiteiA2RU67.

Expressioni

Gene expression databases

BgeeiA2RU67.
CleanExiHS_KIAA1467.
ExpressionAtlasiA2RU67. baseline and differential.
GenevestigatoriA2RU67.

Organism-specific databases

HPAiCAB008385.
HPA010803.

Interactioni

Protein-protein interaction databases

BioGridi121660. 10 interactions.
IntActiA2RU67. 1 interaction.
STRINGi9606.ENSP00000197268.

Structurei

3D structure databases

ProteinModelPortaliA2RU67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ITFG3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG69883.
GeneTreeiENSGT00530000063694.
HOGENOMiHOG000113167.
HOVERGENiHBG101158.
InParanoidiA2RU67.
OMAiIFVQAQN.
OrthoDBiEOG783MWS.
PhylomeDBiA2RU67.
TreeFamiTF327203.

Family and domain databases

Gene3Di2.140.10.10. 2 hits.
InterProiIPR027295. Quinonprotein_ADH-like_fam.
IPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 3 hits.

Sequencei

Sequence statusi: Complete.

A2RU67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQKNGGVKNG
60 70 80 90 100
KSPLGEAPEP DSDAEVAEAA KPHLSEVTTE GYPSEPLGGL EQKAASSLVS
110 120 130 140 150
YVRTSVFLLT LGISMILVLL CAFLIPCPPR DLHSTWSRHL GSQGGGDLSP
160 170 180 190 200
LELADVNGDG LRDVLLSFVM SRNGSAVGVS RPAANLVCLS GMNGSTLWSS
210 220 230 240 250
LLPEEARDIT CLELMPGSLA ETICLVTGTH KMLSAFNATS GKAIWTLNPN
260 270 280 290 300
YLSNGTLAAP VVVLPDLDED GVRDLVVLAI GELQPDLCFL LVSGRTGNPV
310 320 330 340 350
GRPVKYNIVG VGNLIGPQVY ITTNGAVYIL FGFGNIQAVA LRDIFVQAQN
360 370 380 390 400
RDSSPPSLQI EEPEWEKRRS INLSELIDVY SDGVELLQMV KAPDSNCSNL
410 420 430 440 450
LITTRQSLVL LRGQNLTPYW ALRLQGLRSQ PTPGYFTDDQ TLDFLLQIQD
460 470 480 490 500
GVGMKKMMVV DGDSGSIVWS YRAPCHMKET PATSAVTSDQ KSVFLFWAEG
510 520 530 540 550
LSAASPNSDI ILGTEPPSLH HLYLLHPAFP SILLDLANTT GTVTASEVGI
560 570 580 590 600
NDLWKDAFYV TRTTGPSSEG HPAALVVSKL SLRWALMEGQ MAQLQESTPK
610 620
IGRGELRRFL SRIKFVEAPY EI
Length:622
Mass (Da):67,039
Last modified:March 6, 2007 - v1
Checksum:i2C03F481C2FA7DC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591E → K in BAC86111 (PubMed:14702039).Curated
Sequence conflicti91 – 911E → K in AAH39267 (PubMed:15489334).Curated
Sequence conflicti189 – 1891L → P in BAC86111 (PubMed:14702039).Curated
Sequence conflicti450 – 4501D → N in CAI56785 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125278 mRNA. Translation: BAC86111.1.
CR936647 mRNA. Translation: CAI56785.1.
BC039267 mRNA. Translation: AAH39267.1.
BC132772 mRNA. Translation: AAI32773.1.
BC132774 mRNA. Translation: AAI32775.1.
AB040900 mRNA. Translation: BAA95991.1.
CCDSiCCDS31750.1.
RefSeqiNP_065904.1. NM_020853.1.
UniGeneiHs.132660.

Genome annotation databases

EnsembliENST00000197268; ENSP00000197268; ENSG00000084444.
ENST00000416494; ENSP00000394063; ENSG00000084444.
GeneIDi57613.
KEGGihsa:57613.
UCSCiuc001rbi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125278 mRNA. Translation: BAC86111.1.
CR936647 mRNA. Translation: CAI56785.1.
BC039267 mRNA. Translation: AAH39267.1.
BC132772 mRNA. Translation: AAI32773.1.
BC132774 mRNA. Translation: AAI32775.1.
AB040900 mRNA. Translation: BAA95991.1.
CCDSiCCDS31750.1.
RefSeqiNP_065904.1. NM_020853.1.
UniGeneiHs.132660.

3D structure databases

ProteinModelPortaliA2RU67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121660. 10 interactions.
IntActiA2RU67. 1 interaction.
STRINGi9606.ENSP00000197268.

PTM databases

PhosphoSiteiA2RU67.

Proteomic databases

MaxQBiA2RU67.
PaxDbiA2RU67.
PRIDEiA2RU67.

Protocols and materials databases

DNASUi57613.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000197268; ENSP00000197268; ENSG00000084444.
ENST00000416494; ENSP00000394063; ENSG00000084444.
GeneIDi57613.
KEGGihsa:57613.
UCSCiuc001rbi.3. human.

Organism-specific databases

CTDi57613.
GeneCardsiGC12P013197.
HGNCiHGNC:29288. KIAA1467.
HPAiCAB008385.
HPA010803.
neXtProtiNX_A2RU67.
PharmGKBiPA128395790.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG69883.
GeneTreeiENSGT00530000063694.
HOGENOMiHOG000113167.
HOVERGENiHBG101158.
InParanoidiA2RU67.
OMAiIFVQAQN.
OrthoDBiEOG783MWS.
PhylomeDBiA2RU67.
TreeFamiTF327203.

Miscellaneous databases

ChiTaRSiKIAA1467. human.
GenomeRNAii57613.
NextBioi64268.

Gene expression databases

BgeeiA2RU67.
CleanExiHS_KIAA1467.
ExpressionAtlasiA2RU67. baseline and differential.
GenevestigatoriA2RU67.

Family and domain databases

Gene3Di2.140.10.10. 2 hits.
InterProiIPR027295. Quinonprotein_ADH-like_fam.
IPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-622.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-30; SER-33 AND SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-26 AND SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK1467_HUMAN
AccessioniPrimary (citable) accession number: A2RU67
Secondary accession number(s): Q49AF2
, Q5CZ81, Q6ZUV7, Q9P261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 6, 2007
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.