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A2RU67 (K1467_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein KIAA1467
Gene names
Name:KIAA1467
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the ITFG3 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622Uncharacterized protein KIAA1467
PRO_0000288913

Regions

Transmembrane104 – 12421Helical; Potential

Amino acid modifications

Modified residue161Phosphoserine Ref.5 Ref.6
Modified residue301Phosphoserine Ref.5
Modified residue331Phosphoserine Ref.5 Ref.6
Modified residue621Phosphoserine Ref.5

Experimental info

Sequence conflict591E → K in BAC86111. Ref.1
Sequence conflict911E → K in AAH39267. Ref.3
Sequence conflict1891L → P in BAC86111. Ref.1
Sequence conflict4501D → N in CAI56785. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A2RU67 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 2C03F481C2FA7DC0

FASTA62267,039
        10         20         30         40         50         60 
MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQKNGGVKNG KSPLGEAPEP 

        70         80         90        100        110        120 
DSDAEVAEAA KPHLSEVTTE GYPSEPLGGL EQKAASSLVS YVRTSVFLLT LGISMILVLL 

       130        140        150        160        170        180 
CAFLIPCPPR DLHSTWSRHL GSQGGGDLSP LELADVNGDG LRDVLLSFVM SRNGSAVGVS 

       190        200        210        220        230        240 
RPAANLVCLS GMNGSTLWSS LLPEEARDIT CLELMPGSLA ETICLVTGTH KMLSAFNATS 

       250        260        270        280        290        300 
GKAIWTLNPN YLSNGTLAAP VVVLPDLDED GVRDLVVLAI GELQPDLCFL LVSGRTGNPV 

       310        320        330        340        350        360 
GRPVKYNIVG VGNLIGPQVY ITTNGAVYIL FGFGNIQAVA LRDIFVQAQN RDSSPPSLQI 

       370        380        390        400        410        420 
EEPEWEKRRS INLSELIDVY SDGVELLQMV KAPDSNCSNL LITTRQSLVL LRGQNLTPYW 

       430        440        450        460        470        480 
ALRLQGLRSQ PTPGYFTDDQ TLDFLLQIQD GVGMKKMMVV DGDSGSIVWS YRAPCHMKET 

       490        500        510        520        530        540 
PATSAVTSDQ KSVFLFWAEG LSAASPNSDI ILGTEPPSLH HLYLLHPAFP SILLDLANTT 

       550        560        570        580        590        600 
GTVTASEVGI NDLWKDAFYV TRTTGPSSEG HPAALVVSKL SLRWALMEGQ MAQLQESTPK 

       610        620 
IGRGELRRFL SRIKFVEAPY EI 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-622.
Tissue: Brain.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-30; SER-33 AND SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK125278 mRNA. Translation: BAC86111.1.
CR936647 mRNA. Translation: CAI56785.1.
BC039267 mRNA. Translation: AAH39267.1.
BC132772 mRNA. Translation: AAI32773.1.
BC132774 mRNA. Translation: AAI32775.1.
AB040900 mRNA. Translation: BAA95991.1.
CCDSCCDS31750.1.
RefSeqNP_065904.1. NM_020853.1.
UniGeneHs.132660.

3D structure databases

ProteinModelPortalA2RU67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121660. 2 interactions.
IntActA2RU67. 1 interaction.
STRING9606.ENSP00000197268.

PTM databases

PhosphoSiteA2RU67.

Proteomic databases

MaxQBA2RU67.
PaxDbA2RU67.
PRIDEA2RU67.

Protocols and materials databases

DNASU57613.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000197268; ENSP00000197268; ENSG00000084444.
ENST00000416494; ENSP00000394063; ENSG00000084444.
GeneID57613.
KEGGhsa:57613.
UCSCuc001rbi.3. human.

Organism-specific databases

CTD57613.
GeneCardsGC12P013197.
HGNCHGNC:29288. KIAA1467.
HPACAB008385.
HPA010803.
neXtProtNX_A2RU67.
PharmGKBPA128395790.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69883.
HOGENOMHOG000113167.
HOVERGENHBG101158.
InParanoidA2RU67.
OMAIFVQAQN.
OrthoDBEOG783MWS.
PhylomeDBA2RU67.
TreeFamTF327203.

Gene expression databases

ArrayExpressA2RU67.
BgeeA2RU67.
CleanExHS_KIAA1467.
GenevestigatorA2RU67.

Family and domain databases

Gene3D2.140.10.10. 2 hits.
InterProIPR027295. Quinonprotein_ADH-like_fam.
IPR011047. Quinonprotein_ADH-like_supfam.
[Graphical view]
SUPFAMSSF50998. SSF50998. 3 hits.
ProtoNetSearch...

Other

ChiTaRSKIAA1467. human.
GenomeRNAi57613.
NextBio64268.

Entry information

Entry nameK1467_HUMAN
AccessionPrimary (citable) accession number: A2RU67
Secondary accession number(s): Q49AF2 expand/collapse secondary AC list , Q5CZ81, Q6ZUV7, Q9P261
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM