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A2RU54

- HMX2_HUMAN

UniProt

A2RU54 - HMX2_HUMAN

Protein

Homeobox protein HMX2

Gene

HMX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell differentiation Source: UniProtKB-KW
    3. inner ear morphogenesis Source: Ensembl
    4. positive regulation of cell proliferation Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein HMX2
    Alternative name(s):
    Homeobox protein H6 family member 2
    Gene namesi
    Name:HMX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:5018. HMX2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Homeobox protein HMX2PRO_0000294366Add
    BLAST

    Proteomic databases

    PaxDbiA2RU54.
    PRIDEiA2RU54.

    PTM databases

    PhosphoSiteiA2RU54.

    Expressioni

    Gene expression databases

    BgeeiA2RU54.
    CleanExiHS_HMX2.
    GenevestigatoriA2RU54.

    Organism-specific databases

    HPAiHPA043379.

    Interactioni

    Protein-protein interaction databases

    IntActiA2RU54. 2 interactions.
    STRINGi9606.ENSP00000341108.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RU54.
    SMRiA2RU54. Positions 128-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG297994.
    HOGENOMiHOG000231923.
    HOVERGENiHBG045543.
    InParanoidiA2RU54.
    KOiK09349.
    OMAiFPCLGTP.
    OrthoDBiEOG7B8S4Q.
    PhylomeDBiA2RU54.
    TreeFamiTF320562.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2RU54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS    50
    SEEEEPDDGW KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP 100
    GGLERTPFLS PSHSDFKEEK ERLLPAGSPS PGSERPRDGG AERQAGAAKK 150
    KTRTVFSRSQ VYQLESTFDM KRYLSSSERA CLASSLQLTE TQVKTWFQNR 200
    RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV PVPRSLAFPA 250
    PLYYPGSNLS ALPLYNLYNK LDY 273
    Length:273
    Mass (Da):29,598
    Last modified:March 6, 2007 - v1
    Checksum:i1100C836F8D131F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471066 Genomic DNA. Translation: EAW49288.1.
    BC132758 mRNA. Translation: AAI32759.1.
    BC137139 mRNA. Translation: AAI37140.1.
    CCDSiCCDS31305.1.
    RefSeqiNP_005510.1. NM_005519.1.
    XP_005269800.1. XM_005269743.2.
    UniGeneiHs.444756.

    Genome annotation databases

    EnsembliENST00000339992; ENSP00000341108; ENSG00000188816.
    GeneIDi3167.
    KEGGihsa:3167.
    UCSCiuc001lhc.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471066 Genomic DNA. Translation: EAW49288.1 .
    BC132758 mRNA. Translation: AAI32759.1 .
    BC137139 mRNA. Translation: AAI37140.1 .
    CCDSi CCDS31305.1.
    RefSeqi NP_005510.1. NM_005519.1.
    XP_005269800.1. XM_005269743.2.
    UniGenei Hs.444756.

    3D structure databases

    ProteinModelPortali A2RU54.
    SMRi A2RU54. Positions 128-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2RU54. 2 interactions.
    STRINGi 9606.ENSP00000341108.

    PTM databases

    PhosphoSitei A2RU54.

    Proteomic databases

    PaxDbi A2RU54.
    PRIDEi A2RU54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339992 ; ENSP00000341108 ; ENSG00000188816 .
    GeneIDi 3167.
    KEGGi hsa:3167.
    UCSCi uc001lhc.1. human.

    Organism-specific databases

    CTDi 3167.
    GeneCardsi GC10P124897.
    HGNCi HGNC:5018. HMX2.
    HPAi HPA043379.
    MIMi 600647. gene.
    neXtProti NX_A2RU54.
    PharmGKBi PA29345.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297994.
    HOGENOMi HOG000231923.
    HOVERGENi HBG045543.
    InParanoidi A2RU54.
    KOi K09349.
    OMAi FPCLGTP.
    OrthoDBi EOG7B8S4Q.
    PhylomeDBi A2RU54.
    TreeFami TF320562.

    Miscellaneous databases

    GenomeRNAii 3167.
    NextBioi 12560.
    PROi A2RU54.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2RU54.
    CleanExi HS_HMX2.
    Genevestigatori A2RU54.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiHMX2_HUMAN
    AccessioniPrimary (citable) accession number: A2RU54
    Secondary accession number(s): B2RNV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3