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A2RU54 (HMX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein HMX2
Alternative name(s):
Homeobox protein H6 family member 2
Gene names
Name:HMX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the HMX homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Homeobox protein HMX2
PRO_0000294366

Regions

DNA binding149 – 20860Homeobox

Sequences

Sequence LengthMass (Da)Tools
A2RU54 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 1100C836F8D131F1

FASTA27329,598
        10         20         30         40         50         60 
MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW 

        70         80         90        100        110        120 
KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK 

       130        140        150        160        170        180 
ERLLPAGSPS PGSERPRDGG AERQAGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA 

       190        200        210        220        230        240 
CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV 

       250        260        270 
PVPRSLAFPA PLYYPGSNLS ALPLYNLYNK LDY 

« Hide

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471066 Genomic DNA. Translation: EAW49288.1.
BC132758 mRNA. Translation: AAI32759.1.
BC137139 mRNA. Translation: AAI37140.1.
CCDSCCDS31305.1.
RefSeqNP_005510.1. NM_005519.1.
XP_005269800.1. XM_005269743.2.
UniGeneHs.444756.

3D structure databases

ProteinModelPortalA2RU54.
SMRA2RU54. Positions 128-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActA2RU54. 2 interactions.
STRING9606.ENSP00000341108.

PTM databases

PhosphoSiteA2RU54.

Proteomic databases

PaxDbA2RU54.
PRIDEA2RU54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339992; ENSP00000341108; ENSG00000188816.
GeneID3167.
KEGGhsa:3167.
UCSCuc001lhc.1. human.

Organism-specific databases

CTD3167.
GeneCardsGC10P124897.
HGNCHGNC:5018. HMX2.
HPAHPA043379.
MIM600647. gene.
neXtProtNX_A2RU54.
PharmGKBPA29345.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297994.
HOGENOMHOG000231923.
HOVERGENHBG045543.
InParanoidA2RU54.
KOK09349.
OMAFPCLGTP.
OrthoDBEOG7B8S4Q.
PhylomeDBA2RU54.
TreeFamTF320562.

Gene expression databases

BgeeA2RU54.
CleanExHS_HMX2.
GenevestigatorA2RU54.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3167.
NextBio12560.
PROA2RU54.
SOURCESearch...

Entry information

Entry nameHMX2_HUMAN
AccessionPrimary (citable) accession number: A2RU54
Secondary accession number(s): B2RNV5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM