A2RU54 (HMX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein HMX2

Alternative name(s):
Homeobox protein H6 family member 2

Gene names

Name:

HMX2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the HMX homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW inner ear morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Homeobox protein HMX2		PRO_0000294366
Regions
	DNA binding	149 – 208	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	A2RU54 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 1100C836F8D131F1	FASTA	273	29,598
	10 20 30 40 50 60 MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW 70 80 90 100 110 120 KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK 130 140 150 160 170 180 ERLLPAGSPS PGSERPRDGG AERQAGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA 190 200 210 220 230 240 CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV 250 260 270 PVPRSLAFPA PLYYPGSNLS ALPLYNLYNK LDY

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471066 Genomic DNA. Translation: EAW49288.1. BC132758 mRNA. Translation: AAI32759.1. BC137139 mRNA. Translation: AAI37140.1.
IPI	IPI00398900.
RefSeq	NP_005510.1. NM_005519.1.
UniGene	Hs.444756.
3D structure databases
ProteinModelPortal	A2RU54.
ModBase	Search...
Protein-protein interaction databases
IntAct	A2RU54. 2 interactions.
STRING	9606.ENSP00000341108.
PTM databases
PhosphoSite	A2RU54.
Proteomic databases
PaxDb	A2RU54.
PRIDE	A2RU54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339992; ENSP00000341108; ENSG00000188816.
GeneID	3167.
KEGG	hsa:3167.
UCSC	uc001lhc.1. human.
Organism-specific databases
CTD	3167.
GeneCards	GC10P124897.
HGNC	HGNC:5018. HMX2.
HPA	HPA043379.
MIM	600647. gene.
neXtProt	NX_A2RU54.
PharmGKB	PA29345.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297994.
HOGENOM	HOG000231923.
HOVERGEN	HBG045543.
InParanoid	A2RU54.
KO	K09349.
OMA	PFPCLGT.
OrthoDB	EOG44F69R.
PhylomeDB	A2RU54.
Gene expression databases
Bgee	A2RU54.
CleanEx	HS_HMX2.
Genevestigator	A2RU54.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3167.
NextBio	12560.
SOURCE	Search...

Entry information

Entry name

HMX2_HUMAN

Accession

Primary (citable) accession number: A2RU54
Secondary accession number(s): B2RNV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.