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Protein

Homeobox protein HMX2

Gene

HMX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 208HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HMX2
Alternative name(s):
Homeobox protein H6 family member 2
Gene namesi
Name:HMX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:5018. HMX2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188816.
PharmGKBiPA29345.

Polymorphism and mutation databases

BioMutaiHMX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943661 – 273Homeobox protein HMX2Add BLAST273

Proteomic databases

PaxDbiA2RU54.
PRIDEiA2RU54.
TopDownProteomicsiA2RU54.

PTM databases

iPTMnetiA2RU54.
PhosphoSitePlusiA2RU54.

Expressioni

Gene expression databases

BgeeiENSG00000188816.
CleanExiHS_HMX2.
GenevisibleiA2RU54. HS.

Organism-specific databases

HPAiHPA043379.

Interactioni

Protein-protein interaction databases

IntActiA2RU54. 2 interactors.
STRINGi9606.ENSP00000341108.

Structurei

3D structure databases

ProteinModelPortaliA2RU54.
SMRiA2RU54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231923.
HOVERGENiHBG045543.
InParanoidiA2RU54.
KOiK09349.
OMAiFPCLGTP.
OrthoDBiEOG091G0RNV.
PhylomeDBiA2RU54.
TreeFamiTF320562.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS
60 70 80 90 100
SEEEEPDDGW KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP
110 120 130 140 150
GGLERTPFLS PSHSDFKEEK ERLLPAGSPS PGSERPRDGG AERQAGAAKK
160 170 180 190 200
KTRTVFSRSQ VYQLESTFDM KRYLSSSERA CLASSLQLTE TQVKTWFQNR
210 220 230 240 250
RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV PVPRSLAFPA
260 270
PLYYPGSNLS ALPLYNLYNK LDY
Length:273
Mass (Da):29,598
Last modified:March 6, 2007 - v1
Checksum:i1100C836F8D131F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471066 Genomic DNA. Translation: EAW49288.1.
BC132758 mRNA. Translation: AAI32759.1.
BC137139 mRNA. Translation: AAI37140.1.
CCDSiCCDS31305.1.
RefSeqiNP_005510.1. NM_005519.1.
XP_005269800.1. XM_005269743.3.
UniGeneiHs.444756.

Genome annotation databases

EnsembliENST00000339992; ENSP00000341108; ENSG00000188816.
GeneIDi3167.
KEGGihsa:3167.
UCSCiuc001lhc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471066 Genomic DNA. Translation: EAW49288.1.
BC132758 mRNA. Translation: AAI32759.1.
BC137139 mRNA. Translation: AAI37140.1.
CCDSiCCDS31305.1.
RefSeqiNP_005510.1. NM_005519.1.
XP_005269800.1. XM_005269743.3.
UniGeneiHs.444756.

3D structure databases

ProteinModelPortaliA2RU54.
SMRiA2RU54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2RU54. 2 interactors.
STRINGi9606.ENSP00000341108.

PTM databases

iPTMnetiA2RU54.
PhosphoSitePlusiA2RU54.

Polymorphism and mutation databases

BioMutaiHMX2.

Proteomic databases

PaxDbiA2RU54.
PRIDEiA2RU54.
TopDownProteomicsiA2RU54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339992; ENSP00000341108; ENSG00000188816.
GeneIDi3167.
KEGGihsa:3167.
UCSCiuc001lhc.1. human.

Organism-specific databases

CTDi3167.
GeneCardsiHMX2.
HGNCiHGNC:5018. HMX2.
HPAiHPA043379.
MIMi600647. gene.
neXtProtiNX_A2RU54.
OpenTargetsiENSG00000188816.
PharmGKBiPA29345.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231923.
HOVERGENiHBG045543.
InParanoidiA2RU54.
KOiK09349.
OMAiFPCLGTP.
OrthoDBiEOG091G0RNV.
PhylomeDBiA2RU54.
TreeFamiTF320562.

Enzyme and pathway databases

BioCyciZFISH:G66-33452-MONOMER.

Miscellaneous databases

GenomeRNAii3167.
PROiA2RU54.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188816.
CleanExiHS_HMX2.
GenevisibleiA2RU54. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMX2_HUMAN
AccessioniPrimary (citable) accession number: A2RU54
Secondary accession number(s): B2RNV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.