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A2RU54

- HMX2_HUMAN

UniProt

A2RU54 - HMX2_HUMAN

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Protein

Homeobox protein HMX2

Gene

HMX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell differentiation Source: UniProtKB-KW
  3. inner ear morphogenesis Source: Ensembl
  4. positive regulation of cell proliferation Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HMX2
Alternative name(s):
Homeobox protein H6 family member 2
Gene namesi
Name:HMX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:5018. HMX2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Homeobox protein HMX2PRO_0000294366Add
BLAST

Proteomic databases

PaxDbiA2RU54.
PRIDEiA2RU54.

PTM databases

PhosphoSiteiA2RU54.

Expressioni

Gene expression databases

BgeeiA2RU54.
CleanExiHS_HMX2.
GenevestigatoriA2RU54.

Organism-specific databases

HPAiHPA043379.

Interactioni

Protein-protein interaction databases

IntActiA2RU54. 2 interactions.
STRINGi9606.ENSP00000341108.

Structurei

3D structure databases

ProteinModelPortaliA2RU54.
SMRiA2RU54. Positions 128-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG297994.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG045543.
InParanoidiA2RU54.
KOiK09349.
OMAiFPCLGTP.
OrthoDBiEOG7B8S4Q.
PhylomeDBiA2RU54.
TreeFamiTF320562.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RU54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS
60 70 80 90 100
SEEEEPDDGW KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP
110 120 130 140 150
GGLERTPFLS PSHSDFKEEK ERLLPAGSPS PGSERPRDGG AERQAGAAKK
160 170 180 190 200
KTRTVFSRSQ VYQLESTFDM KRYLSSSERA CLASSLQLTE TQVKTWFQNR
210 220 230 240 250
RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV PVPRSLAFPA
260 270
PLYYPGSNLS ALPLYNLYNK LDY
Length:273
Mass (Da):29,598
Last modified:March 6, 2007 - v1
Checksum:i1100C836F8D131F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471066 Genomic DNA. Translation: EAW49288.1.
BC132758 mRNA. Translation: AAI32759.1.
BC137139 mRNA. Translation: AAI37140.1.
CCDSiCCDS31305.1.
RefSeqiNP_005510.1. NM_005519.1.
XP_005269800.1. XM_005269743.2.
UniGeneiHs.444756.

Genome annotation databases

EnsembliENST00000339992; ENSP00000341108; ENSG00000188816.
GeneIDi3167.
KEGGihsa:3167.
UCSCiuc001lhc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471066 Genomic DNA. Translation: EAW49288.1 .
BC132758 mRNA. Translation: AAI32759.1 .
BC137139 mRNA. Translation: AAI37140.1 .
CCDSi CCDS31305.1.
RefSeqi NP_005510.1. NM_005519.1.
XP_005269800.1. XM_005269743.2.
UniGenei Hs.444756.

3D structure databases

ProteinModelPortali A2RU54.
SMRi A2RU54. Positions 128-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi A2RU54. 2 interactions.
STRINGi 9606.ENSP00000341108.

PTM databases

PhosphoSitei A2RU54.

Proteomic databases

PaxDbi A2RU54.
PRIDEi A2RU54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339992 ; ENSP00000341108 ; ENSG00000188816 .
GeneIDi 3167.
KEGGi hsa:3167.
UCSCi uc001lhc.1. human.

Organism-specific databases

CTDi 3167.
GeneCardsi GC10P124897.
HGNCi HGNC:5018. HMX2.
HPAi HPA043379.
MIMi 600647. gene.
neXtProti NX_A2RU54.
PharmGKBi PA29345.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297994.
GeneTreei ENSGT00760000118779.
HOGENOMi HOG000231923.
HOVERGENi HBG045543.
InParanoidi A2RU54.
KOi K09349.
OMAi FPCLGTP.
OrthoDBi EOG7B8S4Q.
PhylomeDBi A2RU54.
TreeFami TF320562.

Miscellaneous databases

GenomeRNAii 3167.
NextBioi 12560.
PROi A2RU54.
SOURCEi Search...

Gene expression databases

Bgeei A2RU54.
CleanExi HS_HMX2.
Genevestigatori A2RU54.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHMX2_HUMAN
AccessioniPrimary (citable) accession number: A2RU54
Secondary accession number(s): B2RNV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3