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Protein

Transmembrane protein 218

Gene

TMEM218

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ciliary biogenesis or function.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 218
Gene namesi
Name:TMEM218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27344. TMEM218.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated
  • Cell projectioncilium By similarity

  • Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi219854.
OpenTargetsiENSG00000150433.
PharmGKBiPA162406569.

Polymorphism and mutation databases

BioMutaiTMEM218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218361 – 115Transmembrane protein 218Add BLAST115

Proteomic databases

PaxDbiA2RU14.
PRIDEiA2RU14.
TopDownProteomicsiA2RU14.

Expressioni

Gene expression databases

BgeeiENSG00000150433.
CleanExiHS_TMEM218.
ExpressionAtlasiA2RU14. baseline and differential.
GenevisibleiA2RU14. HS.

Organism-specific databases

HPAiHPA038489.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA85EBI-10173151,EBI-6942903
LDLRAD1Q5T7005EBI-10173151,EBI-10173166
PCNAP120043EBI-10173151,EBI-358311

Protein-protein interaction databases

BioGridi128583. 3 interactors.
IntActiA2RU14. 6 interactors.
STRINGi9606.ENSP00000279968.

Structurei

3D structure databases

ProteinModelPortaliA2RU14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM218 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J07M. Eukaryota.
ENOG4112157. LUCA.
GeneTreeiENSGT00390000016247.
HOGENOMiHOG000082500.
HOVERGENiHBG095699.
InParanoidiA2RU14.
PhylomeDBiA2RU14.
TreeFamiTF328597.

Family and domain databases

InterProiIPR026771. Tmem218.
[Graphical view]
PANTHERiPTHR31622. PTHR31622. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RU14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTVLGVGA GVFILALLWV AVLLLCVLLS RASGAARFSV IFLFFGAVII
60 70 80 90 100
TSVLLLFPRA GEFPAPEVEV KIVDDFFIGR YVLLAFLSAI FLGGLFLVLI
110
HYVLEPIYAK PLHSY
Length:115
Mass (Da):12,459
Last modified:March 6, 2007 - v1
Checksum:i82641C83F92E2337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA. Translation: EAW67625.1.
BC132716 mRNA. Translation: AAI32717.1.
BC132718 mRNA. Translation: AAI32719.1.
BC144270 mRNA. Translation: AAI44271.1.
BC144277 mRNA. Translation: AAI44278.1.
CCDSiCCDS31715.1.
RefSeqiNP_001074015.1. NM_001080546.2.
NP_001245167.1. NM_001258238.1.
NP_001245168.1. NM_001258239.1.
NP_001245169.1. NM_001258240.1.
NP_001245170.1. NM_001258241.1.
NP_001245171.1. NM_001258242.1.
NP_001245172.1. NM_001258243.1.
NP_001245173.1. NM_001258244.1.
NP_001245174.1. NM_001258245.1.
NP_001245175.1. NM_001258246.1.
NP_001245176.1. NM_001258247.1.
XP_006718846.1. XM_006718783.3.
XP_016872811.1. XM_017017322.1.
XP_016872812.1. XM_017017323.1.
XP_016872813.1. XM_017017324.1.
UniGeneiHs.731899.
Hs.7626.

Genome annotation databases

EnsembliENST00000279968; ENSP00000279968; ENSG00000150433.
ENST00000526175; ENSP00000436177; ENSG00000150433.
ENST00000527271; ENSP00000436162; ENSG00000150433.
ENST00000527766; ENSP00000435526; ENSG00000150433.
ENST00000529583; ENSP00000433374; ENSG00000150433.
ENST00000531909; ENSP00000436596; ENSG00000150433.
ENST00000532407; ENSP00000434597; ENSG00000150433.
GeneIDi219854.
KEGGihsa:219854.
UCSCiuc010sax.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA. Translation: EAW67625.1.
BC132716 mRNA. Translation: AAI32717.1.
BC132718 mRNA. Translation: AAI32719.1.
BC144270 mRNA. Translation: AAI44271.1.
BC144277 mRNA. Translation: AAI44278.1.
CCDSiCCDS31715.1.
RefSeqiNP_001074015.1. NM_001080546.2.
NP_001245167.1. NM_001258238.1.
NP_001245168.1. NM_001258239.1.
NP_001245169.1. NM_001258240.1.
NP_001245170.1. NM_001258241.1.
NP_001245171.1. NM_001258242.1.
NP_001245172.1. NM_001258243.1.
NP_001245173.1. NM_001258244.1.
NP_001245174.1. NM_001258245.1.
NP_001245175.1. NM_001258246.1.
NP_001245176.1. NM_001258247.1.
XP_006718846.1. XM_006718783.3.
XP_016872811.1. XM_017017322.1.
XP_016872812.1. XM_017017323.1.
XP_016872813.1. XM_017017324.1.
UniGeneiHs.731899.
Hs.7626.

3D structure databases

ProteinModelPortaliA2RU14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128583. 3 interactors.
IntActiA2RU14. 6 interactors.
STRINGi9606.ENSP00000279968.

Polymorphism and mutation databases

BioMutaiTMEM218.

Proteomic databases

PaxDbiA2RU14.
PRIDEiA2RU14.
TopDownProteomicsiA2RU14.

Protocols and materials databases

DNASUi219854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279968; ENSP00000279968; ENSG00000150433.
ENST00000526175; ENSP00000436177; ENSG00000150433.
ENST00000527271; ENSP00000436162; ENSG00000150433.
ENST00000527766; ENSP00000435526; ENSG00000150433.
ENST00000529583; ENSP00000433374; ENSG00000150433.
ENST00000531909; ENSP00000436596; ENSG00000150433.
ENST00000532407; ENSP00000434597; ENSG00000150433.
GeneIDi219854.
KEGGihsa:219854.
UCSCiuc010sax.5. human.

Organism-specific databases

CTDi219854.
DisGeNETi219854.
GeneCardsiTMEM218.
HGNCiHGNC:27344. TMEM218.
HPAiHPA038489.
neXtProtiNX_A2RU14.
OpenTargetsiENSG00000150433.
PharmGKBiPA162406569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J07M. Eukaryota.
ENOG4112157. LUCA.
GeneTreeiENSGT00390000016247.
HOGENOMiHOG000082500.
HOVERGENiHBG095699.
InParanoidiA2RU14.
PhylomeDBiA2RU14.
TreeFamiTF328597.

Miscellaneous databases

ChiTaRSiTMEM218. human.
GenomeRNAii219854.
PROiA2RU14.

Gene expression databases

BgeeiENSG00000150433.
CleanExiHS_TMEM218.
ExpressionAtlasiA2RU14. baseline and differential.
GenevisibleiA2RU14. HS.

Family and domain databases

InterProiIPR026771. Tmem218.
[Graphical view]
PANTHERiPTHR31622. PTHR31622. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM218_HUMAN
AccessioniPrimary (citable) accession number: A2RU14
Secondary accession number(s): B7ZM48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.