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Protein

Probable threonine--tRNA ligase 2, cytoplasmic

Gene

TARSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS11920-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable threonine--tRNA ligase 2, cytoplasmic (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Threonyl-tRNA synthetase-like protein 2
Gene namesi
Name:TARSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24728. TARSL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi123283.
OpenTargetsiENSG00000185418.
PharmGKBiPA128394753.

Polymorphism and mutation databases

BioMutaiTARSL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003338282 – 802Probable threonine--tRNA ligase 2, cytoplasmicAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei453PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2RTX5.
MaxQBiA2RTX5.
PaxDbiA2RTX5.
PRIDEiA2RTX5.

PTM databases

iPTMnetiA2RTX5.
PhosphoSitePlusiA2RTX5.

Expressioni

Gene expression databases

BgeeiENSG00000185418.
CleanExiHS_TARSL2.
ExpressionAtlasiA2RTX5. baseline and differential.
GenevisibleiA2RTX5. HS.

Organism-specific databases

HPAiHPA063963.
HPA066697.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B2RDX53EBI-1056629,EBI-10173104
TARSP266395EBI-1056629,EBI-1042683

Protein-protein interaction databases

BioGridi125822. 33 interactors.
IntActiA2RTX5. 17 interactors.
STRINGi9606.ENSP00000338093.

Structurei

3D structure databases

ProteinModelPortaliA2RTX5.
SMRiA2RTX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3 – 23Sequence analysisAdd BLAST21
Coiled coili76 – 96Sequence analysisAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOGENOMiHOG000003878.
HOVERGENiHBG059513.
InParanoidiA2RTX5.
KOiK01868.
OMAiFYYDFAY.
OrthoDBiEOG091G01UL.
PhylomeDBiA2RTX5.
TreeFamiTF300858.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RTX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEALAAEA VASRLERQEE DIRWLWSEVE RLRDEQLNAP YSCQAEGPCL
60 70 80 90 100
TREVAQLRAE NCDLRHRLCS LRLCLAEERS RQATLESAEL EAAQEAGAQP
110 120 130 140 150
PPSQSQDKDM KKKKMKESEA DSEVKHQPIF IKERLKLFEI LKKDHQLLLA
160 170 180 190 200
IYGKKGDTSN IITVRVADGQ TVQGEVWKTT PYQVAAEISQ ELAESTVIAK
210 220 230 240 250
VNGELWDLDR PLEGDSSLEL LTFDNEEAQA VYWHSSAHIL GEAMELYYGG
260 270 280 290 300
HLCYGPPIEN GFYYDMFIED RAVSSTELSA LENICKAIIK EKQPFERLEV
310 320 330 340 350
SKEILLEMFK YNKFKCRILN EKVNTATTTV YRCGPLIDLC KGPHVRHTGK
360 370 380 390 400
IKTIKIFKNS STYWEGNPEM ETLQRIYGIS FPDNKMMRDW EKFQEEAKNR
410 420 430 440 450
DHRKIGKEQE LFFFHDLSPG SCFFLPRGAF IYNTLTDFIR EEYHKRDFTE
460 470 480 490 500
VLSPNMYNSK LWEASGHWQH YSENMFTFEI EKDTFALKPM NCPGHCLMFA
510 520 530 540 550
HRPRSWREMP IRFADFGVLH RNELSGTLSG LTRVRRFQQD DAHIFCTVEQ
560 570 580 590 600
IEEEIKGCLQ FLQSVYSTFG FSFQLNLSTR PENFLGEIEM WNEAEKQLQN
610 620 630 640 650
SLMDFGEPWK MNPGDGAFYG PKIDIKIKDA IGRYHQCATI QLDFQLPIRF
660 670 680 690 700
NLTYVSKDGD DKKRPVIIHR AILGSVERMI AILSENYGGK WPFWLSPRQV
710 720 730 740 750
MVIPVGPTCE KYALQVSSEF FEEGFMADVD LDHSCTLNKK IRNAQLAQYN
760 770 780 790 800
FILVVGEKEK IDNAVNVRTR DNKIHGEILV TSAIDKLKNL RKTRTLNAEE

AF
Length:802
Mass (Da):92,646
Last modified:March 6, 2007 - v1
Checksum:iEE83EB934B503E59
GO
Isoform 2 (identifier: A2RTX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-319: Missing.

Show »
Length:707
Mass (Da):81,561
Checksum:i060179AFC7232B3B
GO

Sequence cautioni

The sequence BAB71554 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96A → G in BAB71241 (PubMed:14702039).Curated1
Sequence conflicti166V → A in BAB71241 (PubMed:14702039).Curated1
Sequence conflicti210R → C in BAB71241 (PubMed:14702039).Curated1
Sequence conflicti337I → N in AAH69346 (PubMed:15489334).Curated1
Sequence conflicti337I → N in AAH69811 (PubMed:15489334).Curated1
Sequence conflicti513F → C in BAB71554 (PubMed:14702039).Curated1
Sequence conflicti533R → G in BAB71554 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033562225 – 319Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056653 mRNA. Translation: BAB71241.1.
AK057734 mRNA. Translation: BAB71554.1. Different initiation.
CH471101 Genomic DNA. Translation: EAX02316.1.
BC069346 mRNA. Translation: AAH69346.1.
BC069811 mRNA. Translation: AAH69811.1.
BC074887 mRNA. Translation: AAH74887.1.
BC132671 mRNA. Translation: AAI32672.1.
BC136315 mRNA. Translation: AAI36316.1.
CCDSiCCDS10394.1. [A2RTX5-1]
RefSeqiNP_689547.2. NM_152334.2. [A2RTX5-1]
UniGeneiHs.657163.

Genome annotation databases

EnsembliENST00000335968; ENSP00000338093; ENSG00000185418. [A2RTX5-1]
GeneIDi123283.
KEGGihsa:123283.
UCSCiuc002bxm.4. human. [A2RTX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056653 mRNA. Translation: BAB71241.1.
AK057734 mRNA. Translation: BAB71554.1. Different initiation.
CH471101 Genomic DNA. Translation: EAX02316.1.
BC069346 mRNA. Translation: AAH69346.1.
BC069811 mRNA. Translation: AAH69811.1.
BC074887 mRNA. Translation: AAH74887.1.
BC132671 mRNA. Translation: AAI32672.1.
BC136315 mRNA. Translation: AAI36316.1.
CCDSiCCDS10394.1. [A2RTX5-1]
RefSeqiNP_689547.2. NM_152334.2. [A2RTX5-1]
UniGeneiHs.657163.

3D structure databases

ProteinModelPortaliA2RTX5.
SMRiA2RTX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125822. 33 interactors.
IntActiA2RTX5. 17 interactors.
STRINGi9606.ENSP00000338093.

PTM databases

iPTMnetiA2RTX5.
PhosphoSitePlusiA2RTX5.

Polymorphism and mutation databases

BioMutaiTARSL2.

Proteomic databases

EPDiA2RTX5.
MaxQBiA2RTX5.
PaxDbiA2RTX5.
PRIDEiA2RTX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335968; ENSP00000338093; ENSG00000185418. [A2RTX5-1]
GeneIDi123283.
KEGGihsa:123283.
UCSCiuc002bxm.4. human. [A2RTX5-1]

Organism-specific databases

CTDi123283.
DisGeNETi123283.
GeneCardsiTARSL2.
HGNCiHGNC:24728. TARSL2.
HPAiHPA063963.
HPA066697.
neXtProtiNX_A2RTX5.
OpenTargetsiENSG00000185418.
PharmGKBiPA128394753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOGENOMiHOG000003878.
HOVERGENiHBG059513.
InParanoidiA2RTX5.
KOiK01868.
OMAiFYYDFAY.
OrthoDBiEOG091G01UL.
PhylomeDBiA2RTX5.
TreeFamiTF300858.

Enzyme and pathway databases

BioCyciZFISH:HS11920-MONOMER.

Miscellaneous databases

ChiTaRSiTARSL2. human.
GenomeRNAii123283.
PROiA2RTX5.

Gene expression databases

BgeeiENSG00000185418.
CleanExiHS_TARSL2.
ExpressionAtlasiA2RTX5. baseline and differential.
GenevisibleiA2RTX5. HS.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYTC2_HUMAN
AccessioniPrimary (citable) accession number: A2RTX5
Secondary accession number(s): B2RMP7
, Q6B0A1, Q6IS76, Q96LW3, Q96MP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.