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A2RTX5

- SYTC2_HUMAN

UniProt

A2RTX5 - SYTC2_HUMAN

Protein

Probable threonine--tRNA ligase 2, cytoplasmic

Gene

TARSL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. threonine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable threonine--tRNA ligase 2, cytoplasmic (EC:6.1.1.3)
    Alternative name(s):
    Threonyl-tRNA synthetase
    Short name:
    ThrRS
    Threonyl-tRNA synthetase-like protein 2
    Gene namesi
    Name:TARSL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:24728. TARSL2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 802801Probable threonine--tRNA ligase 2, cytoplasmicPRO_0000333828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiA2RTX5.
    PaxDbiA2RTX5.
    PRIDEiA2RTX5.

    PTM databases

    PhosphoSiteiA2RTX5.

    Expressioni

    Gene expression databases

    ArrayExpressiA2RTX5.
    BgeeiA2RTX5.
    CleanExiHS_TARSL2.
    GenevestigatoriA2RTX5.

    Interactioni

    Protein-protein interaction databases

    BioGridi125822. 1 interaction.
    STRINGi9606.ENSP00000338093.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RTX5.
    SMRiA2RTX5. Positions 162-800.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili3 – 2321Sequence AnalysisAdd
    BLAST
    Coiled coili76 – 9621Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003878.
    HOVERGENiHBG059513.
    InParanoidiA2RTX5.
    KOiK01868.
    OMAiHFKLQKI.
    OrthoDBiEOG7JDQX3.
    PhylomeDBiA2RTX5.
    TreeFamiTF300858.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2RTX5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEALAAEA VASRLERQEE DIRWLWSEVE RLRDEQLNAP YSCQAEGPCL    50
    TREVAQLRAE NCDLRHRLCS LRLCLAEERS RQATLESAEL EAAQEAGAQP 100
    PPSQSQDKDM KKKKMKESEA DSEVKHQPIF IKERLKLFEI LKKDHQLLLA 150
    IYGKKGDTSN IITVRVADGQ TVQGEVWKTT PYQVAAEISQ ELAESTVIAK 200
    VNGELWDLDR PLEGDSSLEL LTFDNEEAQA VYWHSSAHIL GEAMELYYGG 250
    HLCYGPPIEN GFYYDMFIED RAVSSTELSA LENICKAIIK EKQPFERLEV 300
    SKEILLEMFK YNKFKCRILN EKVNTATTTV YRCGPLIDLC KGPHVRHTGK 350
    IKTIKIFKNS STYWEGNPEM ETLQRIYGIS FPDNKMMRDW EKFQEEAKNR 400
    DHRKIGKEQE LFFFHDLSPG SCFFLPRGAF IYNTLTDFIR EEYHKRDFTE 450
    VLSPNMYNSK LWEASGHWQH YSENMFTFEI EKDTFALKPM NCPGHCLMFA 500
    HRPRSWREMP IRFADFGVLH RNELSGTLSG LTRVRRFQQD DAHIFCTVEQ 550
    IEEEIKGCLQ FLQSVYSTFG FSFQLNLSTR PENFLGEIEM WNEAEKQLQN 600
    SLMDFGEPWK MNPGDGAFYG PKIDIKIKDA IGRYHQCATI QLDFQLPIRF 650
    NLTYVSKDGD DKKRPVIIHR AILGSVERMI AILSENYGGK WPFWLSPRQV 700
    MVIPVGPTCE KYALQVSSEF FEEGFMADVD LDHSCTLNKK IRNAQLAQYN 750
    FILVVGEKEK IDNAVNVRTR DNKIHGEILV TSAIDKLKNL RKTRTLNAEE 800
    AF 802
    Length:802
    Mass (Da):92,646
    Last modified:March 6, 2007 - v1
    Checksum:iEE83EB934B503E59
    GO
    Isoform 2 (identifier: A2RTX5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-319: Missing.

    Show »
    Length:707
    Mass (Da):81,561
    Checksum:i060179AFC7232B3B
    GO

    Sequence cautioni

    The sequence BAB71554.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961A → G in BAB71241. (PubMed:14702039)Curated
    Sequence conflicti166 – 1661V → A in BAB71241. (PubMed:14702039)Curated
    Sequence conflicti210 – 2101R → C in BAB71241. (PubMed:14702039)Curated
    Sequence conflicti337 – 3371I → N in AAH69346. (PubMed:15489334)Curated
    Sequence conflicti337 – 3371I → N in AAH69811. (PubMed:15489334)Curated
    Sequence conflicti513 – 5131F → C in BAB71554. (PubMed:14702039)Curated
    Sequence conflicti533 – 5331R → G in BAB71554. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei225 – 31995Missing in isoform 2. 1 PublicationVSP_033562Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056653 mRNA. Translation: BAB71241.1.
    AK057734 mRNA. Translation: BAB71554.1. Different initiation.
    CH471101 Genomic DNA. Translation: EAX02316.1.
    BC069346 mRNA. Translation: AAH69346.1.
    BC069811 mRNA. Translation: AAH69811.1.
    BC074887 mRNA. Translation: AAH74887.1.
    BC132671 mRNA. Translation: AAI32672.1.
    BC136315 mRNA. Translation: AAI36316.1.
    CCDSiCCDS10394.1. [A2RTX5-1]
    RefSeqiNP_689547.2. NM_152334.2. [A2RTX5-1]
    UniGeneiHs.657163.

    Genome annotation databases

    EnsembliENST00000335968; ENSP00000338093; ENSG00000185418. [A2RTX5-1]
    GeneIDi123283.
    KEGGihsa:123283.
    UCSCiuc002bxm.3. human. [A2RTX5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056653 mRNA. Translation: BAB71241.1 .
    AK057734 mRNA. Translation: BAB71554.1 . Different initiation.
    CH471101 Genomic DNA. Translation: EAX02316.1 .
    BC069346 mRNA. Translation: AAH69346.1 .
    BC069811 mRNA. Translation: AAH69811.1 .
    BC074887 mRNA. Translation: AAH74887.1 .
    BC132671 mRNA. Translation: AAI32672.1 .
    BC136315 mRNA. Translation: AAI36316.1 .
    CCDSi CCDS10394.1. [A2RTX5-1 ]
    RefSeqi NP_689547.2. NM_152334.2. [A2RTX5-1 ]
    UniGenei Hs.657163.

    3D structure databases

    ProteinModelPortali A2RTX5.
    SMRi A2RTX5. Positions 162-800.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125822. 1 interaction.
    STRINGi 9606.ENSP00000338093.

    PTM databases

    PhosphoSitei A2RTX5.

    Proteomic databases

    MaxQBi A2RTX5.
    PaxDbi A2RTX5.
    PRIDEi A2RTX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335968 ; ENSP00000338093 ; ENSG00000185418 . [A2RTX5-1 ]
    GeneIDi 123283.
    KEGGi hsa:123283.
    UCSCi uc002bxm.3. human. [A2RTX5-1 ]

    Organism-specific databases

    CTDi 123283.
    GeneCardsi GC15M102193.
    HGNCi HGNC:24728. TARSL2.
    neXtProti NX_A2RTX5.
    PharmGKBi PA128394753.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003878.
    HOVERGENi HBG059513.
    InParanoidi A2RTX5.
    KOi K01868.
    OMAi HFKLQKI.
    OrthoDBi EOG7JDQX3.
    PhylomeDBi A2RTX5.
    TreeFami TF300858.

    Miscellaneous databases

    GenomeRNAii 123283.
    NextBioi 81100.
    PROi A2RTX5.

    Gene expression databases

    ArrayExpressi A2RTX5.
    Bgeei A2RTX5.
    CleanExi HS_TARSL2.
    Genevestigatori A2RTX5.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-802 (ISOFORM 1).
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-802 (ISOFORMS 1/2).
      Tissue: Brain and Lung.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYTC2_HUMAN
    AccessioniPrimary (citable) accession number: A2RTX5
    Secondary accession number(s): B2RMP7
    , Q6B0A1, Q6IS76, Q96LW3, Q96MP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3