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A2RTX5

- SYTC2_HUMAN

UniProt

A2RTX5 - SYTC2_HUMAN

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Protein

Probable threonine--tRNA ligase 2, cytoplasmic

Gene

TARSL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. threonine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable threonine--tRNA ligase 2, cytoplasmic (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Threonyl-tRNA synthetase-like protein 2
Gene namesi
Name:TARSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:24728. TARSL2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 802801Probable threonine--tRNA ligase 2, cytoplasmicPRO_0000333828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiA2RTX5.
PaxDbiA2RTX5.
PRIDEiA2RTX5.

PTM databases

PhosphoSiteiA2RTX5.

Expressioni

Gene expression databases

BgeeiA2RTX5.
CleanExiHS_TARSL2.
ExpressionAtlasiA2RTX5. baseline and differential.
GenevestigatoriA2RTX5.

Interactioni

Protein-protein interaction databases

BioGridi125822. 6 interactions.
STRINGi9606.ENSP00000338093.

Structurei

3D structure databases

ProteinModelPortaliA2RTX5.
SMRiA2RTX5. Positions 162-800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3 – 2321Sequence AnalysisAdd
BLAST
Coiled coili76 – 9621Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0441.
GeneTreeiENSGT00390000002149.
HOGENOMiHOG000003878.
HOVERGENiHBG059513.
InParanoidiA2RTX5.
KOiK01868.
OMAiHFKLQKI.
OrthoDBiEOG7JDQX3.
PhylomeDBiA2RTX5.
TreeFamiTF300858.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2RTX5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEALAAEA VASRLERQEE DIRWLWSEVE RLRDEQLNAP YSCQAEGPCL
60 70 80 90 100
TREVAQLRAE NCDLRHRLCS LRLCLAEERS RQATLESAEL EAAQEAGAQP
110 120 130 140 150
PPSQSQDKDM KKKKMKESEA DSEVKHQPIF IKERLKLFEI LKKDHQLLLA
160 170 180 190 200
IYGKKGDTSN IITVRVADGQ TVQGEVWKTT PYQVAAEISQ ELAESTVIAK
210 220 230 240 250
VNGELWDLDR PLEGDSSLEL LTFDNEEAQA VYWHSSAHIL GEAMELYYGG
260 270 280 290 300
HLCYGPPIEN GFYYDMFIED RAVSSTELSA LENICKAIIK EKQPFERLEV
310 320 330 340 350
SKEILLEMFK YNKFKCRILN EKVNTATTTV YRCGPLIDLC KGPHVRHTGK
360 370 380 390 400
IKTIKIFKNS STYWEGNPEM ETLQRIYGIS FPDNKMMRDW EKFQEEAKNR
410 420 430 440 450
DHRKIGKEQE LFFFHDLSPG SCFFLPRGAF IYNTLTDFIR EEYHKRDFTE
460 470 480 490 500
VLSPNMYNSK LWEASGHWQH YSENMFTFEI EKDTFALKPM NCPGHCLMFA
510 520 530 540 550
HRPRSWREMP IRFADFGVLH RNELSGTLSG LTRVRRFQQD DAHIFCTVEQ
560 570 580 590 600
IEEEIKGCLQ FLQSVYSTFG FSFQLNLSTR PENFLGEIEM WNEAEKQLQN
610 620 630 640 650
SLMDFGEPWK MNPGDGAFYG PKIDIKIKDA IGRYHQCATI QLDFQLPIRF
660 670 680 690 700
NLTYVSKDGD DKKRPVIIHR AILGSVERMI AILSENYGGK WPFWLSPRQV
710 720 730 740 750
MVIPVGPTCE KYALQVSSEF FEEGFMADVD LDHSCTLNKK IRNAQLAQYN
760 770 780 790 800
FILVVGEKEK IDNAVNVRTR DNKIHGEILV TSAIDKLKNL RKTRTLNAEE

AF
Length:802
Mass (Da):92,646
Last modified:March 6, 2007 - v1
Checksum:iEE83EB934B503E59
GO
Isoform 2 (identifier: A2RTX5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-319: Missing.

Show »
Length:707
Mass (Da):81,561
Checksum:i060179AFC7232B3B
GO

Sequence cautioni

The sequence BAB71554.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961A → G in BAB71241. (PubMed:14702039)Curated
Sequence conflicti166 – 1661V → A in BAB71241. (PubMed:14702039)Curated
Sequence conflicti210 – 2101R → C in BAB71241. (PubMed:14702039)Curated
Sequence conflicti337 – 3371I → N in AAH69346. (PubMed:15489334)Curated
Sequence conflicti337 – 3371I → N in AAH69811. (PubMed:15489334)Curated
Sequence conflicti513 – 5131F → C in BAB71554. (PubMed:14702039)Curated
Sequence conflicti533 – 5331R → G in BAB71554. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 31995Missing in isoform 2. 1 PublicationVSP_033562Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056653 mRNA. Translation: BAB71241.1.
AK057734 mRNA. Translation: BAB71554.1. Different initiation.
CH471101 Genomic DNA. Translation: EAX02316.1.
BC069346 mRNA. Translation: AAH69346.1.
BC069811 mRNA. Translation: AAH69811.1.
BC074887 mRNA. Translation: AAH74887.1.
BC132671 mRNA. Translation: AAI32672.1.
BC136315 mRNA. Translation: AAI36316.1.
CCDSiCCDS10394.1. [A2RTX5-1]
RefSeqiNP_689547.2. NM_152334.2. [A2RTX5-1]
UniGeneiHs.657163.

Genome annotation databases

EnsembliENST00000335968; ENSP00000338093; ENSG00000185418. [A2RTX5-1]
GeneIDi123283.
KEGGihsa:123283.
UCSCiuc002bxm.3. human. [A2RTX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056653 mRNA. Translation: BAB71241.1 .
AK057734 mRNA. Translation: BAB71554.1 . Different initiation.
CH471101 Genomic DNA. Translation: EAX02316.1 .
BC069346 mRNA. Translation: AAH69346.1 .
BC069811 mRNA. Translation: AAH69811.1 .
BC074887 mRNA. Translation: AAH74887.1 .
BC132671 mRNA. Translation: AAI32672.1 .
BC136315 mRNA. Translation: AAI36316.1 .
CCDSi CCDS10394.1. [A2RTX5-1 ]
RefSeqi NP_689547.2. NM_152334.2. [A2RTX5-1 ]
UniGenei Hs.657163.

3D structure databases

ProteinModelPortali A2RTX5.
SMRi A2RTX5. Positions 162-800.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125822. 6 interactions.
STRINGi 9606.ENSP00000338093.

PTM databases

PhosphoSitei A2RTX5.

Proteomic databases

MaxQBi A2RTX5.
PaxDbi A2RTX5.
PRIDEi A2RTX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335968 ; ENSP00000338093 ; ENSG00000185418 . [A2RTX5-1 ]
GeneIDi 123283.
KEGGi hsa:123283.
UCSCi uc002bxm.3. human. [A2RTX5-1 ]

Organism-specific databases

CTDi 123283.
GeneCardsi GC15M102193.
HGNCi HGNC:24728. TARSL2.
neXtProti NX_A2RTX5.
PharmGKBi PA128394753.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0441.
GeneTreei ENSGT00390000002149.
HOGENOMi HOG000003878.
HOVERGENi HBG059513.
InParanoidi A2RTX5.
KOi K01868.
OMAi HFKLQKI.
OrthoDBi EOG7JDQX3.
PhylomeDBi A2RTX5.
TreeFami TF300858.

Miscellaneous databases

GenomeRNAii 123283.
NextBioi 81100.
PROi A2RTX5.

Gene expression databases

Bgeei A2RTX5.
CleanExi HS_TARSL2.
ExpressionAtlasi A2RTX5. baseline and differential.
Genevestigatori A2RTX5.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
SMARTi SM00863. tRNA_SAD. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-802 (ISOFORM 1).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-802 (ISOFORMS 1/2).
    Tissue: Brain and Lung.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYTC2_HUMAN
AccessioniPrimary (citable) accession number: A2RTX5
Secondary accession number(s): B2RMP7
, Q6B0A1, Q6IS76, Q96LW3, Q96MP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3