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Protein
Submitted name:

Interleukin 6

Gene

Il6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 6Imported
Submitted name:
Interleukin 6, isoform CRA_bImported
Gene namesi
Name:Il6Imported
ORF Names:mCG_11634Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96559. Il6.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500932879325 – 211Sequence analysisAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 76UniRule annotation
Disulfide bondi99 ↔ 109UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PeptideAtlasiA2RTD1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025746.
ExpressionAtlasiA2RTD1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026845.

Structurei

3D structure databases

ProteinModelPortaliA2RTD1.
SMRiA2RTD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PANTHERiPTHR10078:SF51. PTHR10078:SF51. 1 hit.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RTD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ
60 70 80 90 100
VGGLITHVLW EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY
110 120 130 140 150
QTGYNQEICL LKISSGLLEY HSYLEYMKNN LKDNKKDKAR VLQRDTETLI
160 170 180 190 200
HIFNQEVKDL HKIVLPTPIS NALLTDKLES QKEWLRTKTI QFILKSLEEF
210
LKVTLRSTRQ T
Length:211
Mass (Da):24,384
Last modified:March 6, 2007 - v1
Checksum:iBBB47DDA9E86787A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132458 mRNA. Translation: AAI32459.1.
BC138766 mRNA. Translation: AAI38767.1.
CH466524 Genomic DNA. Translation: EDL37258.1.
RefSeqiNP_112445.1. NM_031168.2.
UniGeneiMm.1019.

Genome annotation databases

GeneIDi16193.
KEGGimmu:16193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132458 mRNA. Translation: AAI32459.1.
BC138766 mRNA. Translation: AAI38767.1.
CH466524 Genomic DNA. Translation: EDL37258.1.
RefSeqiNP_112445.1. NM_031168.2.
UniGeneiMm.1019.

3D structure databases

ProteinModelPortaliA2RTD1.
SMRiA2RTD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026845.

Proteomic databases

PeptideAtlasiA2RTD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16193.
KEGGimmu:16193.

Organism-specific databases

CTDi3569.
MGIiMGI:96559. Il6.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025746.
ExpressionAtlasiA2RTD1. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PANTHERiPTHR10078:SF51. PTHR10078:SF51. 1 hit.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA2RTD1_MOUSE
AccessioniPrimary (citable) accession number: A2RTD1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: April 12, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.