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Protein
Submitted name:

Interleukin 6

Gene

Il6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 6Imported
Submitted name:
Interleukin 6, isoform CRA_bImported
Gene namesi
Name:Il6Imported
ORF Names:mCG_11634Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96559 Il6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501429681725 – 211Sequence analysisAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 76UniRule annotation
Disulfide bondi99 ↔ 109UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000025746
ExpressionAtlasiA2RTD1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA2RTD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
HOVERGENiHBG000471
KOiK05405
OMAiLQAQNQW
OrthoDBiEOG091G0NW5

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

A2RTD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ
60 70 80 90 100
VGGLITHVLW EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY
110 120 130 140 150
QTGYNQEICL LKISSGLLEY HSYLEYMKNN LKDNKKDKAR VLQRDTETLI
160 170 180 190 200
HIFNQEVKDL HKIVLPTPIS NALLTDKLES QKEWLRTKTI QFILKSLEEF
210
LKVTLRSTRQ T
Length:211
Mass (Da):24,384
Last modified:March 6, 2007 - v1
Checksum:iBBB47DDA9E86787A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132458 mRNA Translation: AAI32459.1
BC138766 mRNA Translation: AAI38767.1
CH466524 Genomic DNA Translation: EDL37258.1
RefSeqiNP_112445.1, NM_031168.2
UniGeneiMm.1019

Genome annotation databases

GeneIDi16193
KEGGimmu:16193

Similar proteinsi

Entry informationi

Entry nameiA2RTD1_MOUSE
AccessioniPrimary (citable) accession number: A2RTD1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health