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Protein

DENN domain-containing protein 3

Gene

Dennd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.1 Publication

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • cellular protein catabolic process Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
DENN domain-containing protein 3
Gene namesi
Name:Dennd3
Synonyms:Kiaa0870
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146009. Dennd3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12741274DENN domain-containing protein 3PRO_0000304673Add
BLAST

Proteomic databases

EPDiA2RT67.
MaxQBiA2RT67.
PaxDbiA2RT67.
PeptideAtlasiA2RT67.
PRIDEiA2RT67.

PTM databases

iPTMnetiA2RT67.
PhosphoSiteiA2RT67.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036661.
CleanExiMM_DENND3.
ExpressionAtlasiA2RT67. baseline and differential.
GenevisibleiA2RT67. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046774.

Structurei

3D structure databases

ProteinModelPortaliA2RT67.
SMRiA2RT67. Positions 117-500, 999-1122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 16178UDENNAdd
BLAST
Domaini187 – 373187DENNPROSITE-ProRule annotationAdd
BLAST
Domaini436 – 49964dDENNPROSITE-ProRule annotationAdd
BLAST
Repeati1025 – 106339WD 1Add
BLAST
Repeati1066 – 110742WD 2Add
BLAST
Repeati1241 – 127434WD 3Add
BLAST

Sequence similaritiesi

Contains 1 dDENN domain.PROSITE-ProRule annotation
Contains 1 DENN domain.PROSITE-ProRule annotation
Contains 1 uDENN domain.PROSITE-ProRule annotation
Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQM8. Eukaryota.
ENOG410XTT7. LUCA.
GeneTreeiENSGT00760000118819.
HOGENOMiHOG000060114.
HOVERGENiHBG095574.
InParanoidiA2RT67.
KOiK20162.
OMAiLPKKHMQ.
OrthoDBiEOG091G0EQ9.
PhylomeDBiA2RT67.
TreeFamiTF331814.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02141. DENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RT67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPAARHLS LPSGLLELCA LLGASQDSLR GLEQIAQKRG VKSASSLVPE
60 70 80 90 100
VLSVFVPPFT TKEDGQVPGA SCALGKGRRR SFRKKREKPR MEPWKSHPGD
110 120 130 140 150
SKGPDSEDVT IPGGVDLLAL PQLCFPGCVC VASEPKEDYI HFLVLTDVCG
160 170 180 190 200
NRTYGVVAQY YRPLHDEYCF YNGKSHWEPS VISARCFVPF AVCVVSRFPY
210 220 230 240 250
YNSLKDCLSC LLTHLKLCKD FEVDNHIKDF AARLSLIPSP PPGPLHLIFN
260 270 280 290 300
MKPLQVVFPS RADPESPIVD LDLHLPLLCF RPEKVLQILT CILTEQRIVF
310 320 330 340 350
FSSDWALLTL MAECFVAYLH PLQWQHTFVP ILSGQMLDFV MAPTSFLMGC
360 370 380 390 400
HLDHFEEVRK EADGLVLIDI DHGSVTCSKS SDDNIDIPDV PLLLAQTFIQ
410 420 430 440 450
RVQSLQLHPD LHLAHLSAST DLNEGRARRR AWQQTLNCKI QHITLQLLVG
460 470 480 490 500
IFREVKNHLN YEHRVFNSEE FLKTRAAGDQ QFYKQVLDTY MFHSFLKARL
510 520 530 540 550
NGRMDAFARM DLDTQSEEDR IDRMLISPRR PTVEKMASRK ASPLHITHRR
560 570 580 590 600
MVVSMPNLQD ISLPELPPRN SSLRIMDTSN CRSSSPVLKV TPKSTYMFKI
610 620 630 640 650
PDIHFPLESQ CVQAYYTDFV TLLSKAMALL GPGDSLLLAR YFYLRGLLHL
660 670 680 690 700
MQGQLLSALL DFQNLYKTDI GIFPADLVKR TVESMSASER AQAERTPELR
710 720 730 740 750
RLITEVFDKH GEAPKADDAV KNFELPKKHM QLNDFVKRVQ ESGIVKDAVI
760 770 780 790 800
IHRLFDALTF GHEKQIDPET FRDFYTCWKE TEAEAQEVSL PALLMEHLDK
810 820 830 840 850
NECVYKLSSS VKTNRGVGKI AMTQKRLFLL TEGRPGYVEI ATFRNIEEVK
860 870 880 890 900
NSTVAFLLLR IPTLKIKTVA KKEVFEANLK SECDLWHLMV KEMWAGKQLA
910 920 930 940 950
DDHKDPQYVQ QALTNVLLMD AVVGTLQSPS AIHAASKLAY FDNMKKKSPM
960 970 980 990 1000
AVPKTTSETL KHKINPSAGE TAPQAIEVLL YTPGRLDPAE KVEDAHPKLW
1010 1020 1030 1040 1050
CALNEGKVVV FDASSWTVHQ HCFKVGSSKV NCMVMAEHNQ VWVGSEDSVI
1060 1070 1080 1090 1100
YIINVHSMSC NKQLTDHRSP VTGLAVHNGK KPSEIYSCSL DGTVIAWNVS
1110 1120 1130 1140 1150
TLRVISRFQL SYGDLLSISL HNDRIWCCTV HKILVVTPQG FVRQELKHPK
1160 1170 1180 1190 1200
DASFLAFQLL PEEQQLWAAS TGVSELYMWS LKDLDQPPQK TYLQDCSEVT
1210 1220 1230 1240 1250
CMIRVKRQIW VGGRGLSQGK TRGKIYVMDV EKVTVEKELV AHLDTVRTLC
1260 1270
SAEDRYVLSG AGQEEGKIAI WKVE
Length:1,274
Mass (Da):143,888
Last modified:March 20, 2007 - v2
Checksum:i4C465CE967D72DB5
GO

Sequence cautioni

The sequence BAC35269 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD32324 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261P → S in BAD32324 (PubMed:15368895).Curated
Sequence conflicti1003 – 10031L → Q in BAC35269 (PubMed:16141072).Curated
Sequence conflicti1200 – 12001T → N in BAC35269 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173046 mRNA. Translation: BAD32324.1. Different initiation.
BC132389 mRNA. Translation: AAI32390.2.
BC137791 mRNA. Translation: AAI37792.1.
AK053114 mRNA. Translation: BAC35269.1. Different initiation.
CCDSiCCDS37100.1.
RefSeqiNP_001074535.1. NM_001081066.1.
UniGeneiMm.322557.

Genome annotation databases

EnsembliENSMUST00000043414; ENSMUSP00000046774; ENSMUSG00000036661.
GeneIDi105841.
KEGGimmu:105841.
UCSCiuc007wce.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173046 mRNA. Translation: BAD32324.1. Different initiation.
BC132389 mRNA. Translation: AAI32390.2.
BC137791 mRNA. Translation: AAI37792.1.
AK053114 mRNA. Translation: BAC35269.1. Different initiation.
CCDSiCCDS37100.1.
RefSeqiNP_001074535.1. NM_001081066.1.
UniGeneiMm.322557.

3D structure databases

ProteinModelPortaliA2RT67.
SMRiA2RT67. Positions 117-500, 999-1122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046774.

PTM databases

iPTMnetiA2RT67.
PhosphoSiteiA2RT67.

Proteomic databases

EPDiA2RT67.
MaxQBiA2RT67.
PaxDbiA2RT67.
PeptideAtlasiA2RT67.
PRIDEiA2RT67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043414; ENSMUSP00000046774; ENSMUSG00000036661.
GeneIDi105841.
KEGGimmu:105841.
UCSCiuc007wce.1. mouse.

Organism-specific databases

CTDi22898.
MGIiMGI:2146009. Dennd3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQM8. Eukaryota.
ENOG410XTT7. LUCA.
GeneTreeiENSGT00760000118819.
HOGENOMiHOG000060114.
HOVERGENiHBG095574.
InParanoidiA2RT67.
KOiK20162.
OMAiLPKKHMQ.
OrthoDBiEOG091G0EQ9.
PhylomeDBiA2RT67.
TreeFamiTF331814.

Miscellaneous databases

PROiA2RT67.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036661.
CleanExiMM_DENND3.
ExpressionAtlasiA2RT67. baseline and differential.
GenevisibleiA2RT67. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02141. DENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEND3_MOUSE
AccessioniPrimary (citable) accession number: A2RT67
Secondary accession number(s): B2RQ75, Q69ZX2, Q8C6V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.