ID   FXL16_MOUSE             Reviewed;         479 AA.
AC   A2RT62;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   RecName: Full=F-box/LRR-repeat protein 16;
DE   AltName: Full=F-box and leucine-rich repeat protein 16;
GN   Name=Fbxl16;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-92, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryo;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; BC132383; AAI32384.1; -; mRNA.
DR   CCDS; CCDS50036.1; -.
DR   RefSeq; NP_001157697.1; NM_001164225.1.
DR   RefSeq; XP_006524083.1; XM_006524020.3.
DR   AlphaFoldDB; A2RT62; -.
DR   SMR; A2RT62; -.
DR   BioGRID; 229576; 25.
DR   STRING; 10090.ENSMUSP00000048562; -.
DR   GlyGen; A2RT62; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A2RT62; -.
DR   PhosphoSitePlus; A2RT62; -.
DR   SwissPalm; A2RT62; -.
DR   PaxDb; 10090-ENSMUSP00000048562; -.
DR   PeptideAtlas; A2RT62; -.
DR   ProteomicsDB; 271654; -.
DR   Pumba; A2RT62; -.
DR   Antibodypedia; 22839; 137 antibodies from 26 providers.
DR   DNASU; 214931; -.
DR   Ensembl; ENSMUST00000045692.9; ENSMUSP00000048562.8; ENSMUSG00000025738.9.
DR   Ensembl; ENSMUST00000236165.2; ENSMUSP00000157536.2; ENSMUSG00000025738.9.
DR   GeneID; 214931; -.
DR   KEGG; mmu:214931; -.
DR   UCSC; uc008bcc.2; mouse.
DR   AGR; MGI:2448488; -.
DR   CTD; 146330; -.
DR   MGI; MGI:2448488; Fbxl16.
DR   VEuPathDB; HostDB:ENSMUSG00000025738; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00940000159138; -.
DR   HOGENOM; CLU_027026_1_0_1; -.
DR   InParanoid; A2RT62; -.
DR   OMA; FWAGLMP; -.
DR   OrthoDB; 2938287at2759; -.
DR   PhylomeDB; A2RT62; -.
DR   TreeFam; TF324260; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   BioGRID-ORCS; 214931; 5 hits in 77 CRISPR screens.
DR   PRO; PR:A2RT62; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; A2RT62; Protein.
DR   Bgee; ENSMUSG00000025738; Expressed in dorsal striatum and 210 other cell types or tissues.
DR   ExpressionAtlas; A2RT62; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd22127; F-box_FBXL16; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR13318:SF193; F-BOX_LRR-REPEAT PROTEIN 16; 1.
DR   PANTHER; PTHR13318; UNCHARACTERIZED; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 7.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   Genevisible; A2RT62; MM.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Methylation; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..479
FT                   /note="F-box/LRR-repeat protein 16"
FT                   /id="PRO_0000307721"
FT   DOMAIN          94..139
FT                   /note="F-box"
FT   REPEAT          321..342
FT                   /note="LRR 1"
FT   REPEAT          347..369
FT                   /note="LRR 2"
FT   REPEAT          373..394
FT                   /note="LRR 3"
FT   REPEAT          398..419
FT                   /note="LRR 4"
FT   REPEAT          423..444
FT                   /note="LRR 5"
FT   REPEAT          446..470
FT                   /note="LRR 6"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..91
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         92
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
SQ   SEQUENCE   479 AA;  51878 MW;  B14320A4B15E900B CRC64;
     MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP PPPTLPPPSL
     ATPLSRVALA GGPCPPASGP ASGPVSGPPV ERPPLATDEK ILNGLFWYFS ACEKCILAQV
     CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
     ICEFIDNYSL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
     SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
     LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
     DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
     MRNLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE
//