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Protein

F-box/LRR-repeat protein 16

Gene

Fbxl16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Gene namesi
Name:Fbxl16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2448488. Fbxl16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077211 – 479F-box/LRR-repeat protein 16Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA2RT62.
PeptideAtlasiA2RT62.
PRIDEiA2RT62.

PTM databases

iPTMnetiA2RT62.
PhosphoSitePlusiA2RT62.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025738.
CleanExiMM_FBXL16.
ExpressionAtlasiA2RT62. baseline and differential.
GenevisibleiA2RT62. MM.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi229576. 22 interactors.
STRINGi10090.ENSMUSP00000048562.

Structurei

3D structure databases

ProteinModelPortaliA2RT62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 139F-boxAdd BLAST46
Repeati321 – 342LRR 1Add BLAST22
Repeati347 – 369LRR 2Add BLAST23
Repeati373 – 394LRR 3Add BLAST22
Repeati398 – 419LRR 4Add BLAST22
Repeati423 – 444LRR 5Add BLAST22
Repeati446 – 470LRR 6Add BLAST25

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiA2RT62.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiA2RT62.
TreeFamiTF324260.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RT62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP
60 70 80 90 100
PPPTLPPPSL ATPLSRVALA GGPCPPASGP ASGPVSGPPV ERPPLATDEK
110 120 130 140 150
ILNGLFWYFS ACEKCILAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL
160 170 180 190 200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYSL SKKGVKAMSL
210 220 230 240 250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS
260 270 280 290 300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
310 320 330 340 350
LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS
360 370 380 390 400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR
410 420 430 440 450
SLYLRWCCQV QDFGLKHLLA MRNLRLLSLA GCPLLTTTGL SGLVQLQELE
460 470
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Length:479
Mass (Da):51,878
Last modified:March 6, 2007 - v1
Checksum:iB14320A4B15E900B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132383 mRNA. Translation: AAI32384.1.
CCDSiCCDS50036.1.
RefSeqiNP_001157697.1. NM_001164225.1.
XP_006524083.1. XM_006524020.3.
UniGeneiMm.152289.

Genome annotation databases

EnsembliENSMUST00000045692; ENSMUSP00000048562; ENSMUSG00000025738.
GeneIDi214931.
KEGGimmu:214931.
UCSCiuc008bcc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132383 mRNA. Translation: AAI32384.1.
CCDSiCCDS50036.1.
RefSeqiNP_001157697.1. NM_001164225.1.
XP_006524083.1. XM_006524020.3.
UniGeneiMm.152289.

3D structure databases

ProteinModelPortaliA2RT62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229576. 22 interactors.
STRINGi10090.ENSMUSP00000048562.

PTM databases

iPTMnetiA2RT62.
PhosphoSitePlusiA2RT62.

Proteomic databases

PaxDbiA2RT62.
PeptideAtlasiA2RT62.
PRIDEiA2RT62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045692; ENSMUSP00000048562; ENSMUSG00000025738.
GeneIDi214931.
KEGGimmu:214931.
UCSCiuc008bcc.2. mouse.

Organism-specific databases

CTDi146330.
MGIiMGI:2448488. Fbxl16.

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiA2RT62.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiA2RT62.
TreeFamiTF324260.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiA2RT62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025738.
CleanExiMM_FBXL16.
ExpressionAtlasiA2RT62. baseline and differential.
GenevisibleiA2RT62. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFXL16_MOUSE
AccessioniPrimary (citable) accession number: A2RT62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.