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A2RT62

- FXL16_MOUSE

UniProt

A2RT62 - FXL16_MOUSE

Protein

F-box/LRR-repeat protein 16

Gene

Fbxl16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 16
    Alternative name(s):
    F-box and leucine-rich repeat protein 16
    Gene namesi
    Name:Fbxl16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2448488. Fbxl16.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479F-box/LRR-repeat protein 16PRO_0000307721Add
    BLAST

    Proteomic databases

    MaxQBiA2RT62.
    PaxDbiA2RT62.
    PRIDEiA2RT62.

    Expressioni

    Gene expression databases

    ArrayExpressiA2RT62.
    BgeeiA2RT62.
    CleanExiMM_FBXL16.
    GenevestigatoriA2RT62.

    Interactioni

    Subunit structurei

    Interacts with SKP1 and CUL1.By similarity

    Protein-protein interaction databases

    BioGridi229576. 22 interactions.
    STRINGi10090.ENSMUSP00000048562.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RT62.
    SMRiA2RT62. Positions 192-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 13946F-boxAdd
    BLAST
    Repeati321 – 34222LRR 1Add
    BLAST
    Repeati347 – 36923LRR 2Add
    BLAST
    Repeati373 – 39422LRR 3Add
    BLAST
    Repeati398 – 41922LRR 4Add
    BLAST
    Repeati423 – 44422LRR 5Add
    BLAST
    Repeati446 – 47025LRR 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.Curated
    Contains 6 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG279509.
    HOGENOMiHOG000060108.
    HOVERGENiHBG051675.
    InParanoidiA2RT62.
    KOiK10282.
    OMAiRGFEGFC.
    OrthoDBiEOG75MVVV.
    PhylomeDBiA2RT62.
    TreeFamiTF324260.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR001611. Leu-rich_rpt.
    [Graphical view]
    PfamiPF13504. LRR_7. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2RT62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP    50
    PPPTLPPPSL ATPLSRVALA GGPCPPASGP ASGPVSGPPV ERPPLATDEK 100
    ILNGLFWYFS ACEKCILAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL 150
    PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYSL SKKGVKAMSL 200
    KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS 250
    DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 300
    LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS 350
    LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR 400
    SLYLRWCCQV QDFGLKHLLA MRNLRLLSLA GCPLLTTTGL SGLVQLQELE 450
    ELELTNCPGA TPELFKYFSQ HLPRCLVIE 479
    Length:479
    Mass (Da):51,878
    Last modified:March 6, 2007 - v1
    Checksum:iB14320A4B15E900B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC132383 mRNA. Translation: AAI32384.1.
    CCDSiCCDS50036.1.
    RefSeqiNP_001157697.1. NM_001164225.1.
    XP_006524083.1. XM_006524020.1.
    UniGeneiMm.152289.

    Genome annotation databases

    EnsembliENSMUST00000045692; ENSMUSP00000048562; ENSMUSG00000025738.
    GeneIDi214931.
    KEGGimmu:214931.
    UCSCiuc008bcc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC132383 mRNA. Translation: AAI32384.1 .
    CCDSi CCDS50036.1.
    RefSeqi NP_001157697.1. NM_001164225.1.
    XP_006524083.1. XM_006524020.1.
    UniGenei Mm.152289.

    3D structure databases

    ProteinModelPortali A2RT62.
    SMRi A2RT62. Positions 192-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229576. 22 interactions.
    STRINGi 10090.ENSMUSP00000048562.

    Proteomic databases

    MaxQBi A2RT62.
    PaxDbi A2RT62.
    PRIDEi A2RT62.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045692 ; ENSMUSP00000048562 ; ENSMUSG00000025738 .
    GeneIDi 214931.
    KEGGi mmu:214931.
    UCSCi uc008bcc.2. mouse.

    Organism-specific databases

    CTDi 146330.
    MGIi MGI:2448488. Fbxl16.

    Phylogenomic databases

    eggNOGi NOG279509.
    HOGENOMi HOG000060108.
    HOVERGENi HBG051675.
    InParanoidi A2RT62.
    KOi K10282.
    OMAi RGFEGFC.
    OrthoDBi EOG75MVVV.
    PhylomeDBi A2RT62.
    TreeFami TF324260.

    Miscellaneous databases

    NextBioi 374521.
    PROi A2RT62.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2RT62.
    Bgeei A2RT62.
    CleanExi MM_FBXL16.
    Genevestigatori A2RT62.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR001611. Leu-rich_rpt.
    [Graphical view ]
    Pfami PF13504. LRR_7. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiFXL16_MOUSE
    AccessioniPrimary (citable) accession number: A2RT62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3