Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A2RT62 (FXL16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Gene names
Name:Fbxl16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.

Subunit structure

Interacts with SKP1 and CUL1 By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 6 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479F-box/LRR-repeat protein 16
PRO_0000307721

Regions

Domain94 – 13946F-box
Repeat321 – 34222LRR 1
Repeat347 – 36923LRR 2
Repeat373 – 39422LRR 3
Repeat398 – 41922LRR 4
Repeat423 – 44422LRR 5
Repeat446 – 47025LRR 6

Sequences

Sequence LengthMass (Da)Tools
A2RT62 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: B14320A4B15E900B

FASTA47951,878
        10         20         30         40         50         60 
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP PPPTLPPPSL 

        70         80         90        100        110        120 
ATPLSRVALA GGPCPPASGP ASGPVSGPPV ERPPLATDEK ILNGLFWYFS ACEKCILAQV 

       130        140        150        160        170        180 
CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD 

       190        200        210        220        230        240 
ICEFIDNYSL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL 

       250        260        270        280        290        300 
SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 

       310        320        330        340        350        360 
LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT 

       370        380        390        400        410        420 
DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA 

       430        440        450        460        470 
MRNLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC132383 mRNA. Translation: AAI32384.1.
RefSeqNP_001157697.1. NM_001164225.1.
XP_006524083.1. XM_006524020.1.
UniGeneMm.152289.

3D structure databases

ProteinModelPortalA2RT62.
SMRA2RT62. Positions 96-134, 226-457.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000048562.

Proteomic databases

PaxDbA2RT62.
PRIDEA2RT62.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045692; ENSMUSP00000048562; ENSMUSG00000025738.
GeneID214931.
KEGGmmu:214931.
UCSCuc008bcc.2. mouse.

Organism-specific databases

CTD146330.
MGIMGI:2448488. Fbxl16.

Phylogenomic databases

eggNOGNOG279509.
HOGENOMHOG000060108.
HOVERGENHBG051675.
InParanoidA2RT62.
KOK10282.
OMARGFEGFC.
OrthoDBEOG75MVVV.
PhylomeDBA2RT62.
TreeFamTF324260.

Gene expression databases

ArrayExpressA2RT62.
BgeeA2RT62.
CleanExMM_FBXL16.
GenevestigatorA2RT62.

Family and domain databases

InterProIPR001810. F-box_dom.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
ProtoNetSearch...

Other

NextBio374521.
PROA2RT62.
SOURCESearch...

Entry information

Entry nameFXL16_MOUSE
AccessionPrimary (citable) accession number: A2RT62
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot