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Protein

TRMT1-like protein

Gene

Trmt1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in motor coordination and exploratory behavior.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 203C2H2-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: MGI
  • adult locomotory behavior Source: MGI
  • tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Behavior, tRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, S-adenosyl-L-methionine, tRNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TRMT1-like protein (EC:2.1.1.-)
Gene namesi
Name:Trmt1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916185. Trmt1l.

Pathology & Biotechi

Disruption phenotypei

Mice are viable and show no apparent anatomical defects. However, they display significantly altered motor coordination and aberrant exploratory behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175701 – 728TRMT1-like proteinAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphothreonineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei607PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2RSY6.
MaxQBiA2RSY6.
PaxDbiA2RSY6.
PeptideAtlasiA2RSY6.
PRIDEiA2RSY6.

PTM databases

iPTMnetiA2RSY6.
PhosphoSitePlusiA2RSY6.

Expressioni

Tissue specificityi

Expressed in various neuronal structures during embryonic development, including spinal ganglia, trigeminal nerve and ganglion, olfactory and nasopharyngeal epithelium, nuclei of the metencephalon, thalamus and medulla oblongata. Also expressed in lung, esophagus, epiglottis, ependyma, vertebral column, spinal cord and brown adipose tissue. Expression persists in the adult brain with dynamically changing patterns in cortex and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000053286.
CleanExiMM_1190005F20RIK.

Interactioni

Protein-protein interaction databases

BioGridi221107. 1 interactor.
STRINGi10090.ENSMUSP00000068309.

Structurei

3D structure databases

ProteinModelPortaliA2RSY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 683Trm1 methyltransferasePROSITE-ProRule annotationAdd BLAST460

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.Curated
Contains 1 Trm1 methyltransferase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 203C2H2-typeAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1253. Eukaryota.
COG1867. LUCA.
HOVERGENiHBG057055.
InParanoidiA2RSY6.
PhylomeDBiA2RSY6.
TreeFamiTF300851.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10631. PTHR10631. 2 hits.
PfamiPF02005. TRM. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51626. SAM_MT_TRM1. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RSY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENMAEEELL PQEKEEAQVR VPTPAPDSAP VPAPAADTAL DSAPTPDSDP
60 70 80 90 100
APALAPAPAP ALSPSLASVP EEAESKRHIS IQRRLADLEK LAFGTEGDVD
110 120 130 140 150
SASSLNSDNP GTENSQTCPL CPKEKFRAYS SHKLRRHLQN LHWKISVEFE
160 170 180 190 200
GYRMCICHLA CRPVKPTIVG EQISSKLGAH YHCIICSATI TRRTDMLGHV
210 220 230 240 250
KRHVNKGETK SRYIAASTAK SSNEILKETD TDIQVFPNYS IPQKTDSYFN
260 270 280 290 300
PKMKLNRQII FCTLAALAKE RKPLECLDAF GATGIMGLQW AKHLGNAVKV
310 320 330 340 350
TINDLNENSV TLIQKNCHLN KLKVVVDSEE KEEGDALEDD GTLGDIQVTR
360 370 380 390 400
MDANVLMHLR SFDFIHLDPF GTSVNYLDSA FRNVRNLGIV SVTSTDISSL
410 420 430 440 450
YAKAQHVARR HYGCNIVRTE YYKELAARIV VAAVARAAAR CNKGIEVLFA
460 470 480 490 500
VALEHFVLVV VRVLRGPTSA DETAKKIQYL IHCQWCEERI FQKDGNMVEE
510 520 530 540 550
NPYRQLPCNC HGSMPGKTAI ELGPLWSSSL FNTGFLKRML FESIHHGLDD
560 570 580 590 600
IQPLIKTLIF ESECTPQSQC STHAPSNTNK QEENGVFVKT TDDTTIDIYS
610 620 630 640 650
AQGKRKSNEM AINLAKKQKT DASTAHPPFY YNIHRHSIKG MNMPKLKKFL
660 670 680 690 700
CCLSQAGFRV SRTHFDPMGI RTDAPLMQFK SILLKYSTPT YTGAQSEGQM
710 720
PPAAEDTVTD RVEMSVSDKA EASGCRRW
Length:728
Mass (Da):80,861
Last modified:March 6, 2007 - v1
Checksum:iE39AE788EE72D903
GO
Isoform 2 (identifier: A2RSY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     645-728: KLKKFLCCLS...KAEASGCRRW → NFLSLLQVKKIFVLSFASRLSSKPNSL

Note: No experimental confirmation available.
Show »
Length:671
Mass (Da):74,523
Checksum:iAD2B4691A7E60980
GO
Isoform 3 (identifier: A2RSY6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-285: I → K
     286-728: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,244
Checksum:i3D87F678E8C6B1D1
GO
Isoform 4 (identifier: A2RSY6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-728: Missing.

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):16,214
Checksum:iE90D2FE7B9DA0DE5
GO

Sequence cautioni

The sequence AAH37478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24P → R in BAE26891 (PubMed:16141072).Curated1
Sequence conflicti24P → R in BAE28600 (PubMed:16141072).Curated1
Sequence conflicti24P → R in AAI10426 (PubMed:15489334).Curated1
Sequence conflicti132H → D in BAC40131 (PubMed:16141072).Curated1
Sequence conflicti133K → Q in BAC40131 (PubMed:16141072).Curated1
Sequence conflicti436R → I in BAB23331 (PubMed:16141072).Curated1
Sequence conflicti614L → V in BAE26891 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031044152 – 728Missing in isoform 4. 1 PublicationAdd BLAST577
Alternative sequenceiVSP_031045285I → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_031046286 – 728Missing in isoform 3. 1 PublicationAdd BLAST443
Alternative sequenceiVSP_031047645 – 728KLKKF…GCRRW → NFLSLLQVKKIFVLSFASRL SSKPNSL in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004493 mRNA. Translation: BAB23331.1.
AK088077 mRNA. Translation: BAC40131.1.
AK146088 mRNA. Translation: BAE26891.1.
AK148524 mRNA. Translation: BAE28600.1.
BC022682 mRNA. Translation: AAH22682.1.
BC037478 mRNA. Translation: AAH37478.1. Different initiation.
BC110425 mRNA. Translation: AAI10426.1.
BC132299 mRNA. Translation: AAI32300.1.
CCDSiCCDS15361.1. [A2RSY6-1]
RefSeqiNP_081152.2. NM_026876.3.
UniGeneiMm.289373.

Genome annotation databases

GeneIDi98685.
KEGGimmu:98685.
UCSCiuc007cyr.1. mouse. [A2RSY6-4]
uc007cyt.1. mouse. [A2RSY6-3]
uc007cyu.1. mouse. [A2RSY6-1]
uc029qua.1. mouse. [A2RSY6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004493 mRNA. Translation: BAB23331.1.
AK088077 mRNA. Translation: BAC40131.1.
AK146088 mRNA. Translation: BAE26891.1.
AK148524 mRNA. Translation: BAE28600.1.
BC022682 mRNA. Translation: AAH22682.1.
BC037478 mRNA. Translation: AAH37478.1. Different initiation.
BC110425 mRNA. Translation: AAI10426.1.
BC132299 mRNA. Translation: AAI32300.1.
CCDSiCCDS15361.1. [A2RSY6-1]
RefSeqiNP_081152.2. NM_026876.3.
UniGeneiMm.289373.

3D structure databases

ProteinModelPortaliA2RSY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221107. 1 interactor.
STRINGi10090.ENSMUSP00000068309.

PTM databases

iPTMnetiA2RSY6.
PhosphoSitePlusiA2RSY6.

Proteomic databases

EPDiA2RSY6.
MaxQBiA2RSY6.
PaxDbiA2RSY6.
PeptideAtlasiA2RSY6.
PRIDEiA2RSY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi98685.
KEGGimmu:98685.
UCSCiuc007cyr.1. mouse. [A2RSY6-4]
uc007cyt.1. mouse. [A2RSY6-3]
uc007cyu.1. mouse. [A2RSY6-1]
uc029qua.1. mouse. [A2RSY6-2]

Organism-specific databases

CTDi81627.
MGIiMGI:1916185. Trmt1l.

Phylogenomic databases

eggNOGiKOG1253. Eukaryota.
COG1867. LUCA.
HOVERGENiHBG057055.
InParanoidiA2RSY6.
PhylomeDBiA2RSY6.
TreeFamiTF300851.

Miscellaneous databases

PROiA2RSY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053286.
CleanExiMM_1190005F20RIK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10631. PTHR10631. 2 hits.
PfamiPF02005. TRM. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51626. SAM_MT_TRM1. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM1L_MOUSE
AccessioniPrimary (citable) accession number: A2RSY6
Secondary accession number(s): Q0VGB9
, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.