Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KAT8 regulatory NSL complex subunit 3

Gene

Kansl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Protein family/group databases

ESTHERimouse-Kansl3. NLS3-Tex30.

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 3
Alternative name(s):
NSL complex protein NSL3
Non-specific lethal 3 homolog
Gene namesi
Name:Kansl3
Synonyms:Kiaa1310, Nsl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918055. Kansl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903KAT8 regulatory NSL complex subunit 3PRO_0000287138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei523 – 5231PhosphoserineBy similarity
Modified residuei536 – 5361PhosphoserineCombined sources
Modified residuei540 – 5401PhosphoserineCombined sources
Modified residuei772 – 7721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2RSY1.
MaxQBiA2RSY1.
PaxDbiA2RSY1.
PeptideAtlasiA2RSY1.
PRIDEiA2RSY1.

PTM databases

iPTMnetiA2RSY1.
PhosphoSiteiA2RSY1.

Expressioni

Gene expression databases

BgeeiA2RSY1.
CleanExiMM_4632411B12RIK.
ExpressionAtlasiA2RSY1. baseline and differential.
GenevisibleiA2RSY1. MM.

Interactioni

Subunit structurei

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.By similarity

Protein-protein interaction databases

BioGridi230578. 1 interaction.
IntActiA2RSY1. 1 interaction.
STRINGi10090.ENSMUSP00000010597.

Structurei

3D structure databases

ProteinModelPortaliA2RSY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi699 – 77274Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG3253. Eukaryota.
ENOG410XSH5. LUCA.
GeneTreeiENSGT00390000007636.
HOGENOMiHOG000070219.
HOVERGENiHBG062095.
InParanoidiA2RSY1.
KOiK16719.
OMAiSVNWDTK.
OrthoDBiEOG79SDWJ.
PhylomeDBiA2RSY1.
TreeFamiTF323466.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR026555. NSL3/Tex30.
[Graphical view]
PANTHERiPTHR13136. PTHR13136. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RSY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD
60 70 80 90 100
ASSARPTRML FVTPRRQQEN TIESDVPIDV ETVTATPVPL YDNQKARSVM
110 120 130 140 150
NECERHVIFA RTDADAPPPP EDWEEHVNRT GWTVAQNKLF NKILKALQSD
160 170 180 190 200
RLARLANEGA CNEPVLRRVA VDKCARRVRQ ALASVSWDTK LTQWLHTTLV
210 220 230 240 250
ETLSLPMLAA YLDALQTLKG KIPTLIDRML VSSNTKTGAA GAEALSLLLK
260 270 280 290 300
RPWDPAVGVL SHNKPSKLPG SPLILIVSSG PSSSVFPASR RHRFWQSQLS
310 320 330 340 350
CLGKVIPVAT HLLNNGSGVG VLQCLEHMIG AVRSKVLEIH SHFPHKPIIL
360 370 380 390 400
IGWNTGALVA CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV
410 420 430 440 450
LFVIGQNSLQ CHPEAMEDFR EKIRAENSLV VVGGADDNLR ISKAKKKSEG
460 470 480 490 500
LTQSMVDRCI QDEIVDFLTG VLTRAEGHVG SEPRDQDAEK KKKPRDLTRR
510 520 530 540 550
DLAFEIPERG SRPASPAARL PTSPSGSEDL SSVSSSPTSS PKTKVTTVTS
560 570 580 590 600
TQKSSQIGTS QLLKRHVQRT EAVLTHRQAQ AQFAAFLKQN MLVRKAFPPG
610 620 630 640 650
TSSCLFVPIS SESVEDIEKE ELRVQLKRHH SSSPLPGAKP SKRPKIKVSL
660 670 680 690 700
ISQGDTVGGP CTLSQGGTPE AAGGKPITMT LGASAGAKEL TGLLTTAKSS
710 720 730 740 750
SSEGGGTAST TPSVASSSAT PNAIHTLQSR LVATSPGSSL PGTASASSLL
760 770 780 790 800
QGLSFSLQDI SSKTSGLPGS PSPGPAPQAT SVKLPTPMQS LGAITTGTST
810 820 830 840 850
IVRTIPVATT LSSLGATPGG KPTAIHQLLT NGSLAKLASS LPGLAQISNQ
860 870 880 890 900
ASGLKVPTTI TLTLRGQPSR ITTLSPMGSG ATPSEEPNSQ MLPSSSQRLP

PAP
Length:903
Mass (Da):96,135
Last modified:March 6, 2007 - v1
Checksum:i68D32C689768DB7D
GO
Isoform 2 (identifier: A2RSY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     581-606: Missing.

Show »
Length:877
Mass (Da):93,279
Checksum:iA2FDF15304105FDB
GO
Isoform 3 (identifier: A2RSY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     581-606: Missing.

Note: No experimental confirmation available.
Show »
Length:778
Mass (Da):82,032
Checksum:iC6C4FDB123CF5375
GO

Sequence cautioni

The sequence BAC98139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9999Missing in isoform 3. 1 PublicationVSP_025334Add
BLAST
Alternative sequencei581 – 60626Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025335Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129329 mRNA. Translation: BAC98139.1. Different initiation.
AK030079 mRNA. Translation: BAC26771.1.
BC132293 mRNA. Translation: AAI32294.1.
CCDSiCCDS14877.1. [A2RSY1-2]
CCDS78561.1. [A2RSY1-1]
RefSeqiNP_001297442.1. NM_001310513.1. [A2RSY1-1]
NP_766240.1. NM_172652.3. [A2RSY1-2]
UniGeneiMm.24734.

Genome annotation databases

EnsembliENSMUST00000010597; ENSMUSP00000010597; ENSMUSG00000010453. [A2RSY1-2]
ENSMUST00000185912; ENSMUSP00000140547; ENSMUSG00000010453. [A2RSY1-3]
ENSMUST00000186470; ENSMUSP00000140597; ENSMUSG00000010453. [A2RSY1-1]
GeneIDi226976.
KEGGimmu:226976.
UCSCiuc007apz.1. mouse. [A2RSY1-1]
uc007aqa.1. mouse. [A2RSY1-2]
uc011wjj.1. mouse. [A2RSY1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129329 mRNA. Translation: BAC98139.1. Different initiation.
AK030079 mRNA. Translation: BAC26771.1.
BC132293 mRNA. Translation: AAI32294.1.
CCDSiCCDS14877.1. [A2RSY1-2]
CCDS78561.1. [A2RSY1-1]
RefSeqiNP_001297442.1. NM_001310513.1. [A2RSY1-1]
NP_766240.1. NM_172652.3. [A2RSY1-2]
UniGeneiMm.24734.

3D structure databases

ProteinModelPortaliA2RSY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230578. 1 interaction.
IntActiA2RSY1. 1 interaction.
STRINGi10090.ENSMUSP00000010597.

Protein family/group databases

ESTHERimouse-Kansl3. NLS3-Tex30.

PTM databases

iPTMnetiA2RSY1.
PhosphoSiteiA2RSY1.

Proteomic databases

EPDiA2RSY1.
MaxQBiA2RSY1.
PaxDbiA2RSY1.
PeptideAtlasiA2RSY1.
PRIDEiA2RSY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010597; ENSMUSP00000010597; ENSMUSG00000010453. [A2RSY1-2]
ENSMUST00000185912; ENSMUSP00000140547; ENSMUSG00000010453. [A2RSY1-3]
ENSMUST00000186470; ENSMUSP00000140597; ENSMUSG00000010453. [A2RSY1-1]
GeneIDi226976.
KEGGimmu:226976.
UCSCiuc007apz.1. mouse. [A2RSY1-1]
uc007aqa.1. mouse. [A2RSY1-2]
uc011wjj.1. mouse. [A2RSY1-3]

Organism-specific databases

CTDi55683.
MGIiMGI:1918055. Kansl3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3253. Eukaryota.
ENOG410XSH5. LUCA.
GeneTreeiENSGT00390000007636.
HOGENOMiHOG000070219.
HOVERGENiHBG062095.
InParanoidiA2RSY1.
KOiK16719.
OMAiSVNWDTK.
OrthoDBiEOG79SDWJ.
PhylomeDBiA2RSY1.
TreeFamiTF323466.

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiKansl3. mouse.
PROiA2RSY1.
SOURCEiSearch...

Gene expression databases

BgeeiA2RSY1.
CleanExiMM_4632411B12RIK.
ExpressionAtlasiA2RSY1. baseline and differential.
GenevisibleiA2RSY1. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR026555. NSL3/Tex30.
[Graphical view]
PANTHERiPTHR13136. PTHR13136. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536 AND SER-540, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Spleen.

Entry informationi

Entry nameiKANL3_MOUSE
AccessioniPrimary (citable) accession number: A2RSY1
Secondary accession number(s): Q6ZPU0, Q8C0P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 6, 2007
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.