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A2RST1

- A2RST1_MOUSE

UniProt

A2RST1 - A2RST1_MOUSE

Protein
Submitted name:

Microsomal glutathione S-transferase 2

Gene

Mgst2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro
    2. glutathione peroxidase activity Source: RefGenome
    3. glutathione transferase activity Source: RefGenome
    4. leukotriene-C4 synthase activity Source: RefGenome

    GO - Biological processi

    1. glutathione biosynthetic process Source: Ensembl
    2. leukotriene biosynthetic process Source: RefGenome
    3. oxidation-reduction process Source: GOC
    4. response to lipopolysaccharide Source: Ensembl
    5. response to organonitrogen compound Source: Ensembl

    Keywords - Molecular functioni

    TransferaseImported

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Microsomal glutathione S-transferase 2Imported
    Submitted name:
    Microsomal glutathione S-transferase 2, isoform CRA_cImported
    Submitted name:
    Protein Mgst2Imported
    Gene namesi
    Name:Mgst2Imported
    ORF Names:mCG_22172Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2448481. Mgst2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. integral component of membrane Source: InterPro
    3. nuclear envelope Source: RefGenome
    4. plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriA2RST1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000096705.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG77136.
    GeneTreeiENSGT00430000030964.
    HOGENOMiHOG000116372.
    HOVERGENiHBG105513.
    InParanoidiA2RST1.
    KOiK00799.
    OMAiLYIYARH.
    OrthoDBiEOG7GXPD5.
    TreeFamiTF105328.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR001446. 5_LipOase_AP.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]
    PRINTSiPR00488. 5LPOXGNASEAP.

    Sequencei

    Sequence statusi: Complete.

    A2RST1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGDSSLLAA VSLLSACQQS YFAWRVGRAR LKHKIAPPAV TGPLEFERIF    50
    RAQQNSLEFY PVFIVMLWMA GWYFNQVFAA CLGLLYIYAR HKYFWGYAEA 100
    AEKRITGFRL SLGILTLLPV LAVLGVASRF LNEYLDFHVA KKLRKPF 147
    Length:147
    Mass (Da):16,786
    Last modified:March 6, 2007 - v1
    Checksum:i57CFDC147DDF85E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC102860 Genomic DNA. No translation available.
    AC116729 Genomic DNA. No translation available.
    BC132234 mRNA. Translation: AAI32235.1.
    BC132260 mRNA. Translation: AAI32261.1.
    CH466530 Genomic DNA. Translation: EDL35221.1.
    RefSeqiNP_778160.2. NM_174995.2.
    UniGeneiMm.24679.

    Genome annotation databases

    EnsembliENSMUST00000099106; ENSMUSP00000096705; ENSMUSG00000074604.
    GeneIDi211666.
    KEGGimmu:211666.
    UCSCiuc008ped.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC102860 Genomic DNA. No translation available.
    AC116729 Genomic DNA. No translation available.
    BC132234 mRNA. Translation: AAI32235.1 .
    BC132260 mRNA. Translation: AAI32261.1 .
    CH466530 Genomic DNA. Translation: EDL35221.1 .
    RefSeqi NP_778160.2. NM_174995.2.
    UniGenei Mm.24679.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000096705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099106 ; ENSMUSP00000096705 ; ENSMUSG00000074604 .
    GeneIDi 211666.
    KEGGi mmu:211666.
    UCSCi uc008ped.1. mouse.

    Organism-specific databases

    CTDi 4258.
    MGIi MGI:2448481. Mgst2.

    Phylogenomic databases

    eggNOGi NOG77136.
    GeneTreei ENSGT00430000030964.
    HOGENOMi HOG000116372.
    HOVERGENi HBG105513.
    InParanoidi A2RST1.
    KOi K00799.
    OMAi LYIYARH.
    OrthoDBi EOG7GXPD5.
    TreeFami TF105328.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 373328.
    PROi A2RST1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A2RST1.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR001446. 5_LipOase_AP.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    PRINTSi PR00488. 5LPOXGNASEAP.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TesticleImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2RST1_MOUSE
    AccessioniPrimary (citable) accession number: A2RST1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3